Stability of classification performance on an adaptive neuro fuzzy inference system for disease complication prediction

Abstract

It is crucial to detect disease complications caused by metabolic syndromes early. High cholesterol, high glucose, and high blood pressure are indicators of metabolic syndrome. The aim of this study is to use adaptive neuro fuzzy inference system (ANFIS) to predict potential complications and compare its performance to other classifiers, namely random forest (RF), C4.5, and naïve Bayesian classification (NBC) algorithms. Fuzzy subtractive clustering is used to construct membership functions and fuzzy rules throughout the clustering process. This study analyzed 148 different data sets. Cholesterol, random glucose, systolic, and diastolic blood pressure are all included in the data collection. This learning process was conducted using a hybrid algorithm. The consequent parameters are adjusted forward using the leastsquare approach, while the premise parameters are adjusted backward using the gradient-descent process. The performance of a system is determined by the following indicators: accuracy, sensitivity, specification, precision, area under the curve (AUC), and root mean squared error (RMSE). The results of the training prove that ANFIS is an "excellent classification" classifier. ANFIS has proven to have very good stability across the six performance parameters. The adaptive properties used in ANFIS training and the implementation of fuzzy subtractive clustering strongly support this stability.