The effect of high intensity interval training on telomere length and telomerase activity in non-athlete young men

Saeedreza Noorimofrad, K. Ebrahim
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引用次数: 7

Abstract

Introduction: Telomeres are DNA portions that are located on the two ends of the chromosome. Telomeres play an important role in cellular life. Exercise is one of the factors that contributes to their control. The purpose of the present study was to investigate the effect of 8 weeks of high intensity interval training (HIIT) on telomere length and telomerase activity in non-athletic young men. Materials and methods: 30 inactive students were selected as sample and randomly divided into two groups of exercise (15 people) and control (15 people) in this semi-experimental study. The exercise group performed 8 weeks of HIIT exercise in 3 sessions per week with an intensity of 150 to 175% of their maximum power (Pmax). Control group subjects did not do regular sport activities. To measure telomere length and telomerase activity, 10 ml of blood was taken from the brachial vein of the subjects 24 hours before the first and after the last exercise session. The dependent t was used to analyze intra-group and independent t for within-group differences. Results: The findings of this study showed that 8 weeks of HIIT training in non-athlete young men resulted in a significant increase in telomere length (P = 0.001) and telomerase activity (P = 0.001). Conclusion: It seems that HIIT can alter telomerase activity and telomere length. Therefore, these training may have a positive effect on cell biology.
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高强度间歇训练对非运动员年轻男性端粒长度和端粒酶活性的影响
端粒是位于染色体两端的DNA部分。端粒在细胞生命中起着重要的作用。锻炼是有助于控制他们的因素之一。本研究的目的是研究8周高强度间歇训练(HIIT)对非运动年轻男性端粒长度和端粒酶活性的影响。材料与方法:本半实验研究选取30名不运动学生作为样本,随机分为运动组(15人)和对照组(15人)。运动组进行为期8周的HIIT运动,每周3次,强度为其最大功率(Pmax)的150 - 175%。对照组受试者没有定期进行体育活动。为了测量端粒长度和端粒酶活性,在第一次锻炼前和最后一次锻炼后24小时从受试者的肱静脉中取血10ml。用依赖t分析组内差异,用独立t分析组内差异。结果:本研究结果显示,非运动员年轻男性进行8周的HIIT训练后,端粒长度(P = 0.001)和端粒酶活性(P = 0.001)显著增加。结论:HIIT似乎可以改变端粒酶活性和端粒长度。因此,这些训练可能对细胞生物学有积极的影响。
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