Introduction: Genetic variation between individuals may include single nucleotide polymorphisms. These individual differences could change human phenotypes (such as skeletal structure, heart and lung size). Insulin-like growth factor-I (IGF-I) is a critical factor in growth and exercise-associated muscle development. In this study we analyzed the frequency of IGF-I rs35767 polymorphism in karate-Kas athletes to find whether there is a difference among professional, amateur athletes and non- Karate-Kas. Materials and methods: Two hundred and fifty-four athletes (95 professional Karate-Kas, and 159 amateur Karate-Kas) and 159 non-athletic healthy individuals participated in the current study. Following provision of informed consent, 2 mL of blood samples were taken. After DNA isolation, the genotyping frequencies of the IGF-I gene C/T polymorphism was assessed by restriction fragment length polymorphism (RFLP) analysis. Statistical analyses carried out using SPSS software (version 20) and data with P 1) however, was not significant. Odd ratios of T/T and T/C genotypes compared to C/C in professional group versus controls were 1.125 (95%CI: 0.556 - 2.275) and 1.034 (0.538 - 1.984), respectively. Also, odd ratio of T/T and T/C in amateur group versus controls were 1.002 (0.535 - 1.876) and 1.256 (0.715 - 2.205), respectively. Conclusion: The IGF-I gene C/T polymorphism is not significantly associated with the physical performance´s levels of karate-kas athletes in Iranian population.
{"title":"Lack of association between insulin-like growth factor-I (IGF-I) gene polymorphism (rs35767) and power performance in professional, amateur athletes and non-athlete individuals in Iranian population","authors":"M. Batavani, S. Marandi, K. Ghaedi, F. Esfarjani","doi":"10.29252/JBRMS.5.4.41","DOIUrl":"https://doi.org/10.29252/JBRMS.5.4.41","url":null,"abstract":"Introduction: Genetic variation between individuals may include single nucleotide polymorphisms. These individual differences could change human phenotypes (such as skeletal structure, heart and lung size). Insulin-like growth factor-I (IGF-I) is a critical factor in growth and exercise-associated muscle development. In this study we analyzed the frequency of IGF-I rs35767 polymorphism in karate-Kas athletes to find whether there is a difference among professional, amateur athletes and non- Karate-Kas. Materials and methods: Two hundred and fifty-four athletes (95 professional Karate-Kas, and 159 amateur Karate-Kas) and 159 non-athletic healthy individuals participated in the current study. Following provision of informed consent, 2 mL of blood samples were taken. After DNA isolation, the genotyping frequencies of the IGF-I gene C/T polymorphism was assessed by restriction fragment length polymorphism (RFLP) analysis. Statistical analyses carried out using SPSS software (version 20) and data with P 1) however, was not significant. Odd ratios of T/T and T/C genotypes compared to C/C in professional group versus controls were 1.125 (95%CI: 0.556 - 2.275) and 1.034 (0.538 - 1.984), respectively. Also, odd ratio of T/T and T/C in amateur group versus controls were 1.002 (0.535 - 1.876) and 1.256 (0.715 - 2.205), respectively. Conclusion: The IGF-I gene C/T polymorphism is not significantly associated with the physical performance´s levels of karate-kas athletes in Iranian population.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45615001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The phenomenon of suicide has been considered by experts of social sciences and psychology. Considering the issue of suicide, a precise analysis must first be carried out in a specific geographic region. Secondly, the cultural coordinates of the climate should be taken into account. The purpose of this study was to investigate the factors and methods of suicide in Ilam province. Materials and methods: The statistical population of this research included all suicide cases committed in Ilam province from 2012 to 2016. The total sample size based on the recorded cases from 2012 to 2016 was 3078 cases. Data analysis of this research was done at two levels of descriptive and responding to research questions. At the descriptive level, indicators such as frequency, percentage, cross-tables, and frequency distribution charts were used. In the answer section of the research Kruskal Wallis and Xi-Du were used. Results: There was a significant difference between the frequency of successful and unsuccessful suicides. 10.92% of suicides were successful and 89.08% were unsuccessful. Men tended to suicide more than women, but this was not statistically significant. In some age groups, suicide rates were higher than other groups, 34.7% were suicidal in the 21 to 25 age group, 30.06% in the age group of 31 and older, and 34.24% in the remaining age groups. Considering the methods, 73% of suicides have used pills over the last five years, and there was a significant relationship between the motivation of individuals and their tendency towards suicide (48.4%). Conclusion: The results of this study revealed that in committing suicide the individual, social, and psychological factors play the main roles, the results also presented the rate of being successful or unsuccessful in committing suicides, the gender of these attempters, their age range, the education level, the manner of committing, and finally their motive to commit suicide in years of 2012 to 2016.
{"title":"Investigating the factors and methods of suicide in Ilam province (from 2012 to 2016)","authors":"S. Ahmadi, A. Varvaei, Ghobad Kazemi","doi":"10.29252/JBRMS.5.4.28","DOIUrl":"https://doi.org/10.29252/JBRMS.5.4.28","url":null,"abstract":"Introduction: The phenomenon of suicide has been considered by experts of social sciences and psychology. Considering the issue of suicide, a precise analysis must first be carried out in a specific geographic region. Secondly, the cultural coordinates of the climate should be taken into account. The purpose of this study was to investigate the factors and methods of suicide in Ilam province. Materials and methods: The statistical population of this research included all suicide cases committed in Ilam province from 2012 to 2016. The total sample size based on the recorded cases from 2012 to 2016 was 3078 cases. Data analysis of this research was done at two levels of descriptive and responding to research questions. At the descriptive level, indicators such as frequency, percentage, cross-tables, and frequency distribution charts were used. In the answer section of the research Kruskal Wallis and Xi-Du were used. Results: There was a significant difference between the frequency of successful and unsuccessful suicides. 10.92% of suicides were successful and 89.08% were unsuccessful. Men tended to suicide more than women, but this was not statistically significant. In some age groups, suicide rates were higher than other groups, 34.7% were suicidal in the 21 to 25 age group, 30.06% in the age group of 31 and older, and 34.24% in the remaining age groups. Considering the methods, 73% of suicides have used pills over the last five years, and there was a significant relationship between the motivation of individuals and their tendency towards suicide (48.4%). Conclusion: The results of this study revealed that in committing suicide the individual, social, and psychological factors play the main roles, the results also presented the rate of being successful or unsuccessful in committing suicides, the gender of these attempters, their age range, the education level, the manner of committing, and finally their motive to commit suicide in years of 2012 to 2016.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42200962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Raiesi, Hajar Shabandoust, P. Dehghan, S. Shamsaei, A. Soleimani
Diabetic patients are more susceptible to cutaneous fungal infections. Cutaneous lesions and Foot infections are a frequent complication of patients with diabetes mellitus, accounting for up to 20% of diabetes-related hospital admissions. Foot ulcers and other foot problems are a major cause of morbidity and mortality in people with Diabetes mellitus. The higher blood sugar levels cause increasing the cutaneous fungal infections in these patients. More than 75% of diabetes mellitus (DM) patients are at risk for diabetic ulcers. About 15% of foot ulcers in diabetic patients lead to amputations. Although every 30 seconds one leg is amputated in the world due to DM, 80% of these cases are preventable. Poor controlled had significantly higher fungal infection in diabetic foot ulcers and require careful attention and management. The findings of various studies indicate that the prevalence of fungal infections in patients with diabetic foot ulcers is increasing and there are many drug resistance issues reported in this area, therefore more attention is important in diabetic centers about this neglected issue.
{"title":"Fungal infection in foot diabetic patients","authors":"O. Raiesi, Hajar Shabandoust, P. Dehghan, S. Shamsaei, A. Soleimani","doi":"10.29252/JBRMS.5.4.47","DOIUrl":"https://doi.org/10.29252/JBRMS.5.4.47","url":null,"abstract":"Diabetic patients are more susceptible to cutaneous fungal infections. Cutaneous lesions and Foot infections are a frequent complication of patients with diabetes mellitus, accounting for up to 20% of diabetes-related hospital admissions. Foot ulcers and other foot problems are a major cause of morbidity and mortality in people with Diabetes mellitus. The higher blood sugar levels cause increasing the cutaneous fungal infections in these patients. More than 75% of diabetes mellitus (DM) patients are at risk for diabetic ulcers. About 15% of foot ulcers in diabetic patients lead to amputations. Although every 30 seconds one leg is amputated in the world due to DM, 80% of these cases are preventable. Poor controlled had significantly higher fungal infection in diabetic foot ulcers and require careful attention and management. The findings of various studies indicate that the prevalence of fungal infections in patients with diabetic foot ulcers is increasing and there are many drug resistance issues reported in this area, therefore more attention is important in diabetic centers about this neglected issue.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42251886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khadijeh Abdal, S. Mostafazadeh, Marziyeh Darvishi
Introduction: Cancer is one of the five leading causes of death around the world, and head and neck cancer is one of the most common incidences, leading to the death of thousands of people each year. Given the epidemiological importance of head and neck cancers, this study aimed to examine the prevalence of head and neck cancers over a 10-year period in Ilam. Materials and methods: This descriptive study was done using the files of 1106 patients with head and neck lesions who were referred to Imam Khomeini hospital in Ilam in a 10-year period between 2004 and 2015. All the data in the files, including age, sex, type and location of the lesion, was recorded, evaluated, and analyzed using independent t-tests and chi-square statistical methods with SPSS 19. Results: The annual incidence of head and neck cancers in Ilam was estimated at 1.5 per 100,000 people. Basal cell carcinoma was the most common cancer of the head and neck (18.50%). The most common site of squamous cell carcinoma occurrence was the tongue at 54%. Regarding sex, 55.5% of patients were male and 44.5% were female. Regarding malignancy, 289 lesions (26.13%) were reported as malignant and 817 lesions (73.86%) were reported as benign. Conclusion: Considering the high incidence of basal cell carcinoma and squamous cell carcinoma the importance of early diagnosis of these cancers and their treatment requires appropriate planning to improve survival of these patients and to reduce the diseases complications.
{"title":"The frequency of tumors of the head and neck in a 10-year period in Ilam, Iran","authors":"Khadijeh Abdal, S. Mostafazadeh, Marziyeh Darvishi","doi":"10.29252/JBRMS.5.4.22","DOIUrl":"https://doi.org/10.29252/JBRMS.5.4.22","url":null,"abstract":"Introduction: Cancer is one of the five leading causes of death around the world, and head and neck cancer is one of the most common incidences, leading to the death of thousands of people each year. Given the epidemiological importance of head and neck cancers, this study aimed to examine the prevalence of head and neck cancers over a 10-year period in Ilam. Materials and methods: This descriptive study was done using the files of 1106 patients with head and neck lesions who were referred to Imam Khomeini hospital in Ilam in a 10-year period between 2004 and 2015. All the data in the files, including age, sex, type and location of the lesion, was recorded, evaluated, and analyzed using independent t-tests and chi-square statistical methods with SPSS 19. Results: The annual incidence of head and neck cancers in Ilam was estimated at 1.5 per 100,000 people. Basal cell carcinoma was the most common cancer of the head and neck (18.50%). The most common site of squamous cell carcinoma occurrence was the tongue at 54%. Regarding sex, 55.5% of patients were male and 44.5% were female. Regarding malignancy, 289 lesions (26.13%) were reported as malignant and 817 lesions (73.86%) were reported as benign. Conclusion: Considering the high incidence of basal cell carcinoma and squamous cell carcinoma the importance of early diagnosis of these cancers and their treatment requires appropriate planning to improve survival of these patients and to reduce the diseases complications.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47585706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: In the current study we designed a sophisticated drug delivery nanoparticle to control the methylprednisolone succinate delivery rate and affect the cancer cell growth in culture condition. Materials and methods: Magnetic nanoparticles were synthesized through co-precipitation method. Fe3O4 was first prepared via co-precipitation method and then its surface was functionalized with polyamidoamine (PAMAM) nanodendrimer. PAMAM synthesis trait was detected via FT-IR and SEM methods. Methylprednisolone drug was loaded on PAMAM@Fe3O4 and its effect against cancer cell lines was studied. In order to slow down drug release rate from nanoparticles, PAMAM@Fe3O4 were coated with trimethylchitosan (TMC) after drug loading. Performance of PAMAM@Fe3O4@TMC nanoparticles loaded with mmethylprednisolone, were evaluated against two cell lines to detect the cytotoxic and apoptotic effects by invert light scanning microscopy, immunoassay, and LDH cytotoxicity Kit. Results: According to SEM, image size of Fe3O4 was 4.79-6.37nm, which is smaller than nanodendrimer (6.30-43.67 nm). FT-IR spectrum for ester bond Methylacrylate @ Ethylendiamin was obtained to be 1720-1730 cm-1. FT-IR Spectrums 600 cm-1, 1000 cm-1 belong to Fe3O4, and Fe3O4@ NH2. Also, trimethyl chitosan coated Nanoparticle @ Drug, smearing trimethyl chitosan with Glutaraldehyde, created cross link between TMC monomer at low drug doses in each complete nanoparticle, gave confidence drug side effect, therefore, this nanoparticle could be safe for future cancer therapy. Conclusion: The results showed that drug delivery via PAMAM@Fe3O4 nanoparticle reduces cell viability in vitro condition.
{"title":"Synthesis of poly (amidoamine) (PAMAM) dendrimer-based chitosan for targeted drug delivery and cell therapy","authors":"Leila Sofi Maryo Sofi Maryo, Nahid Haghnazari, F. Keshavarzi, Hassan Zhaleh, Farzad Seidi","doi":"10.29252/JBRMS.5.4.6","DOIUrl":"https://doi.org/10.29252/JBRMS.5.4.6","url":null,"abstract":"Introduction: In the current study we designed a sophisticated drug delivery nanoparticle to control the methylprednisolone succinate delivery rate and affect the cancer cell growth in culture condition. Materials and methods: Magnetic nanoparticles were synthesized through co-precipitation method. Fe3O4 was first prepared via co-precipitation method and then its surface was functionalized with polyamidoamine (PAMAM) nanodendrimer. PAMAM synthesis trait was detected via FT-IR and SEM methods. Methylprednisolone drug was loaded on PAMAM@Fe3O4 and its effect against cancer cell lines was studied. In order to slow down drug release rate from nanoparticles, PAMAM@Fe3O4 were coated with trimethylchitosan (TMC) after drug loading. Performance of PAMAM@Fe3O4@TMC nanoparticles loaded with mmethylprednisolone, were evaluated against two cell lines to detect the cytotoxic and apoptotic effects by invert light scanning microscopy, immunoassay, and LDH cytotoxicity Kit. Results: According to SEM, image size of Fe3O4 was 4.79-6.37nm, which is smaller than nanodendrimer (6.30-43.67 nm). FT-IR spectrum for ester bond Methylacrylate @ Ethylendiamin was obtained to be 1720-1730 cm-1. FT-IR Spectrums 600 cm-1, 1000 cm-1 belong to Fe3O4, and Fe3O4@ NH2. Also, trimethyl chitosan coated Nanoparticle @ Drug, smearing trimethyl chitosan with Glutaraldehyde, created cross link between TMC monomer at low drug doses in each complete nanoparticle, gave confidence drug side effect, therefore, this nanoparticle could be safe for future cancer therapy. Conclusion: The results showed that drug delivery via PAMAM@Fe3O4 nanoparticle reduces cell viability in vitro condition.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48527523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hassan Niroomand, S. Binaafar, A. Shayegan, Mohsen Varyani, B. Rezakhaniha
Introduction: During recent years, considerable efforts have been expended into the management of urinary stone. Here, we present our experience on ureteric stone removal without any lithotripsy interventions. Combination direct vision with basket en-trapping provided a new dimension to our ureteroscope experience. Materials and methods: Here, we reviewed the medical data of our adult patients with ≤10 mm stone size, who received primary stone extraction under direct ureteroscopic vision without lithotripsy during a 2-year period. During the six months of follow-up every patient was seen frequently. Results: The study included69patientsfrombothsexes with agesrangingfrom 18 to 68 years. We obtained 92.7% success rate. The averagelengthofoperativeprocedureswas 25.3 ± 10.4 min with a 14.4 % complication rate. Conclusion: Ureteral stone extraction requires considerable caution and may be associated with some complications. Stone extraction under direct ureteroscope guidance facilitates this procedure, especially in the distal stones. It seems combination direct live imaging with basket en-trapping may be helpful in these precise cases.
{"title":"Ureteral stone extraction under direct ureteroscopic vision: An alternative for routine ureteral stone management","authors":"Hassan Niroomand, S. Binaafar, A. Shayegan, Mohsen Varyani, B. Rezakhaniha","doi":"10.29252/JBRMS.5.4.1","DOIUrl":"https://doi.org/10.29252/JBRMS.5.4.1","url":null,"abstract":"Introduction: During recent years, considerable efforts have been expended into the management of urinary stone. Here, we present our experience on ureteric stone removal without any lithotripsy interventions. Combination direct vision with basket en-trapping provided a new dimension to our ureteroscope experience. Materials and methods: Here, we reviewed the medical data of our adult patients with ≤10 mm stone size, who received primary stone extraction under direct ureteroscopic vision without lithotripsy during a 2-year period. During the six months of follow-up every patient was seen frequently. Results: The study included69patientsfrombothsexes with agesrangingfrom 18 to 68 years. We obtained 92.7% success rate. The averagelengthofoperativeprocedureswas 25.3 ± 10.4 min with a 14.4 % complication rate. Conclusion: Ureteral stone extraction requires considerable caution and may be associated with some complications. Stone extraction under direct ureteroscope guidance facilitates this procedure, especially in the distal stones. It seems combination direct live imaging with basket en-trapping may be helpful in these precise cases.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42321758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: In this study, the effects of the ethanolic extract of aerial parts (stem and leaves) of Smyrnium cordifolium (S. cordifolium) Boiss on the ethylene glycol(EG)-induced kidney calculi in rats was investigated. Materials and methods: Thirty-six male Wistar albino rats were randomly divided in 6 groups. Group I (normal control), Groups II (control of EG) to VI received EG 1% v/v in water for 28 days. Animals in Groups III and IV (preventive groups) received ethanolic extract of stem and leaves of S. cordifolium in 200 mg/kg and 400 mg/kg orally in water for 28 days, respectively. Groups V and VI (treatment groups) received extract in 200 mg/kg and 400 mg/kg orally in water from 15th to 28th day, respectively. Results: Results showed that the level of urine oxalate, blood urea and creatinine in EG group vs. normal control significantly increased (P<0.001). Extract did not show significant effect on urinary oxalate, urine volume and other blood biochemical parameters in the treatment groups (V and VI). Provision of extract resulted in significantly lower levels of urine oxalate and higher level of volume, serum creatinine and blood urea in III and IV groups as compared with Group II (P<0.05). Conclusion: These observations enable us to conclude that the ethanolic extract of aerial parts of S. cordifolium Boiss is effective against EG induced urinary calculi in rats.
{"title":"Therapeutic effects of aerial parts of Smyrnium cordifolium ethanolic extract on ethylene glycol-induced kidney calculi in rats","authors":"Zohreh Dovodizadeh, L. Rouhi, S. Azizi","doi":"10.29252/JBRMS.5.4.14","DOIUrl":"https://doi.org/10.29252/JBRMS.5.4.14","url":null,"abstract":"Introduction: In this study, the effects of the ethanolic extract of aerial parts (stem and leaves) of Smyrnium cordifolium (S. cordifolium) Boiss on the ethylene glycol(EG)-induced kidney calculi in rats was investigated. Materials and methods: Thirty-six male Wistar albino rats were randomly divided in 6 groups. Group I (normal control), Groups II (control of EG) to VI received EG 1% v/v in water for 28 days. Animals in Groups III and IV (preventive groups) received ethanolic extract of stem and leaves of S. cordifolium in 200 mg/kg and 400 mg/kg orally in water for 28 days, respectively. Groups V and VI (treatment groups) received extract in 200 mg/kg and 400 mg/kg orally in water from 15th to 28th day, respectively. Results: Results showed that the level of urine oxalate, blood urea and creatinine in EG group vs. normal control significantly increased (P<0.001). Extract did not show significant effect on urinary oxalate, urine volume and other blood biochemical parameters in the treatment groups (V and VI). Provision of extract resulted in significantly lower levels of urine oxalate and higher level of volume, serum creatinine and blood urea in III and IV groups as compared with Group II (P<0.05). Conclusion: These observations enable us to conclude that the ethanolic extract of aerial parts of S. cordifolium Boiss is effective against EG induced urinary calculi in rats.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47972110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Asadollahi, S. Nabian, M. Taheri, E. Ebrahimzadeh, M. Ranjbar, Razi Vaccine
Introduction: Regarding emerging tick resistance against acaricides, researches have been shifted toward alternative approaches such as immunologic methods. Vaccine preparation is an alternative way in which choosing appropriate protein with high immune induction potency is a prerequisite. In addition according to studies, using more than one protein could better enhance the immune induction and antibody production. Choosing immunogenic epitopes from selected proteins and adjoining them with a suitable linker is one of the novel approaches in vaccine design. Materials and methods: Based on the fact that both cathepsin and tropomyosin proteins of Rhipicephalus tick were previously recognized as potent immunogenic antigens, we predicted the immunogenic epitopes of these proteins by immunoinformatic methods. Among studied epitopes, those that were met by multiple bioinformatics tools were used. Results: Finally, the polytopic construction was designed by assembling the selected epitopes and connecting them with linkers. Conclusion: Using immunoinformatic tools, we predicted the characteristics of two genes of Rhipicephalus annulatus tick larva as fused potent vaccine candidates namely, cathepsin and tropomyosin.
{"title":"Designing of potential vaccine candidates of fused cathepsin L and tropomyosin genes of Rhipicephalus (Boophilus) annulatus tick larva","authors":"Z. Asadollahi, S. Nabian, M. Taheri, E. Ebrahimzadeh, M. Ranjbar, Razi Vaccine","doi":"10.29252/JBRMS.5.3.9","DOIUrl":"https://doi.org/10.29252/JBRMS.5.3.9","url":null,"abstract":"Introduction: Regarding emerging tick resistance against acaricides, researches have been shifted toward alternative approaches such as immunologic methods. Vaccine preparation is an alternative way in which choosing appropriate protein with high immune induction potency is a prerequisite. In addition according to studies, using more than one protein could better enhance the immune induction and antibody production. Choosing immunogenic epitopes from selected proteins and adjoining them with a suitable linker is one of the novel approaches in vaccine design. Materials and methods: Based on the fact that both cathepsin and tropomyosin proteins of Rhipicephalus tick were previously recognized as potent immunogenic antigens, we predicted the immunogenic epitopes of these proteins by immunoinformatic methods. Among studied epitopes, those that were met by multiple bioinformatics tools were used. Results: Finally, the polytopic construction was designed by assembling the selected epitopes and connecting them with linkers. Conclusion: Using immunoinformatic tools, we predicted the characteristics of two genes of Rhipicephalus annulatus tick larva as fused potent vaccine candidates namely, cathepsin and tropomyosin.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45202936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Education and research are two thinking based processes. Nowadays, the main function of educational institutions is evaluated by thinking. This study aimed to determine the dominant thinking styles among medical and dental students of Ilam University of Medical Sciences (IUMS). Materials and methods: This cross-sectional study was conducted on all medical and dental students of IUMS in the academic year of 2016-2017. Data was collected by Sternbergs standard thinking style inventory and a demographic data questionnaire. Data analysis was carried out with the software SPSS 20 using descriptive statistical analysis methods and t-test. Results: In total, 497 students of IUMS participated in the study. Among whom 395 (79.5%) were medicals students and 102 (20.5%) were dental students. The findings showed significant differences between the legislative and executive thinking styles of medical and dental students (P=0.042 and P=0.024 respectively), more specifically, the mean score of legislative thinking style was found to be higher among dental students than that of medical students, and the opposite relation was found in the mean scores of executive thinking style. Comparison of mean scores of thinking style dimensions between medical and dental students showed significant differences in some but not all dimensions. Conclusion: Considering the differences found in thinking styles of medical and dental students and their effects in emergence of unique behavioral and decision-making characteristics in medical and dental students, educational planners and professors should attempt to adjust their teaching methods and professional approach according to students individual features in terms of thinking style and preferences so as to foster the growth and flourish of their thinking, academic, and clinical capabilities. The results of the study showed significant differences between the legislative and executive thinking styles of medical and dental students, also regarding the different dimensions of thinking styles of medical and dental students, some significant differences in some but not all dimensions were reported.
{"title":"Evaluation of thinking style among medical and dental students of Ilam University of Medical Sciences in academic year of 2016-2017","authors":"Sareh Rostami, A. Sohrabnejad, Alireza Mirzaei","doi":"10.29252/JBRMS.5.3.17","DOIUrl":"https://doi.org/10.29252/JBRMS.5.3.17","url":null,"abstract":"Introduction: Education and research are two thinking based processes. Nowadays, the main function of educational institutions is evaluated by thinking. This study aimed to determine the dominant thinking styles among medical and dental students of Ilam University of Medical Sciences (IUMS). Materials and methods: This cross-sectional study was conducted on all medical and dental students of IUMS in the academic year of 2016-2017. Data was collected by Sternbergs standard thinking style inventory and a demographic data questionnaire. Data analysis was carried out with the software SPSS 20 using descriptive statistical analysis methods and t-test. Results: In total, 497 students of IUMS participated in the study. Among whom 395 (79.5%) were medicals students and 102 (20.5%) were dental students. The findings showed significant differences between the legislative and executive thinking styles of medical and dental students (P=0.042 and P=0.024 respectively), more specifically, the mean score of legislative thinking style was found to be higher among dental students than that of medical students, and the opposite relation was found in the mean scores of executive thinking style. Comparison of mean scores of thinking style dimensions between medical and dental students showed significant differences in some but not all dimensions. Conclusion: Considering the differences found in thinking styles of medical and dental students and their effects in emergence of unique behavioral and decision-making characteristics in medical and dental students, educational planners and professors should attempt to adjust their teaching methods and professional approach according to students individual features in terms of thinking style and preferences so as to foster the growth and flourish of their thinking, academic, and clinical capabilities. The results of the study showed significant differences between the legislative and executive thinking styles of medical and dental students, also regarding the different dimensions of thinking styles of medical and dental students, some significant differences in some but not all dimensions were reported.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42343786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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