The enigma of picobirnaviruses: viruses of animals, fungi, or bacteria?

IF 5.7 2区 医学 Q1 VIROLOGY Current opinion in virology Pub Date : 2022-06-01 DOI:10.1016/j.coviro.2022.101232
David Wang
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引用次数: 9

Abstract

Picobirnaviruses are small double-stranded RNA viruses first discovered in 1988 in stool samples from patients with diarrhea. It has generally been assumed that picobirnaviruses infect animal hosts and that they are potential agents of diarrhea, but there is still no direct evidence demonstrating that picobirnaviruses infect animals. In the metagenomic era, virome studies have broadened our understanding of picobirnavirus genetic diversity and genome organization, expanded the types of animals in which they have been detected, and identified novel associations with human disease. Most importantly, from the wealth of new sequencing data and comparative genomic analyses, a provocative new hypothesis has emerged that picobirnaviruses may not infect animals, but rather that they may infect evolutionarily simpler denizens of the gastrointestinal tract: bacteria and/or fungi. Depending on whether the true hosts of picobirnaviruses are animals, fungi, or bacteria, the mechanisms by which they impact animal biology will vary dramatically.

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小核糖核酸病毒之谜:动物病毒、真菌病毒还是细菌病毒?
小核糖核酸病毒是一种小的双链RNA病毒,于1988年首次在腹泻患者的粪便样本中发现。一般认为,小核糖核酸病毒感染动物宿主,它们是腹泻的潜在病原体,但仍然没有直接证据表明小核糖核酸病毒感染动物。在宏基因组时代,病毒组研究扩大了我们对小核糖核酸病毒遗传多样性和基因组组织的理解,扩大了已检测到小核糖核酸病毒的动物类型,并确定了与人类疾病的新关联。最重要的是,从丰富的新测序数据和比较基因组分析中,出现了一个具有挑衅性的新假设,即小核糖核酸病毒可能不会感染动物,而是可能感染进化上更简单的胃肠道居民:细菌和/或真菌。根据小核糖核酸病毒的真正宿主是动物、真菌还是细菌,它们影响动物生物学的机制将会有很大的不同。
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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
期刊最新文献
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