Development of dietary fiber psyllium based hydrogel for use in drug delivery applications

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2022-12-01 DOI:10.1016/j.fhfh.2022.100059

Baljit Singh, Vikrant Sharma, Rajender Kumar, Man Mohan

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引用次数: 8

Abstract

Keeping in view the therapeutic and gel forming role of the psyllium seed mucilage in pharmaceutical industries, herein this article, its potential has been explored for developing the drug delivery (DD) carrier. The main aim of the study was to modify the psyllium polysaccharides through grafting and crosslinking of 2-methacryloyloxyethyl trimethylammonium chloride onto psyllium to develop the hydrogels for use in DD application. Various thermal, mechanical, physiochemical, biomedical properties of the hydrogel were determined along with characterization with ¹³C NMR, FTIR, XRD, TGA, DSC and AFM. The release of antibiotic drug cefuroxime occurred in sustained manner and followed Fickian diffusion mechanism and was best fitted in Higuchi kinetic model. The networks showed mesh size in the range between 25.14 to 38.92 nm during the change in crosslinker content in copolymerization reaction. It has been inferred from the results that these hydrogels could be used as a potential carrier for drug delivery.

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膳食纤维车前草基水凝胶的开发，用于药物输送应用

鉴于车前草种子粘液在制药工业中的治疗作用和成胶作用，本文探讨了车前草种子粘液在开发给药载体方面的潜力。本研究的主要目的是通过2-甲基丙烯酰氧乙基三甲基氯化铵在车前草上接枝交联对车前草多糖进行改性，制备用于DD应用的水凝胶。通过13C NMR、FTIR、XRD、TGA、DSC、AFM等表征手段，测定了水凝胶的各种热、力学、理化、生物医学性能。头孢呋辛的释放过程持续，符合Fickian扩散机制，符合Higuchi动力学模型。共聚反应中，随着交联剂含量的变化，网状物的网孔大小在25.14 ~ 38.92 nm之间。结果表明，这些水凝胶可以作为一种潜在的药物递送载体。

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