Evaluation of the diagnostic accuracy of galactomannan from the bronchoalveolar lavage fluid of patients with suspected invasive pulmonary aspergillosis

IF 1.5 4区生物学 Q4 MYCOLOGY Revista Iberoamericana De Micologia Pub Date : 2022-04-01 DOI:10.1016/j.riam.2021.07.002

Rafaela Manzoni Bernardi , Sizuane Rieger Holler , Ellis Gabriela Correa de Almeida , Camila Anton , Felipe Dominguez Machado , Denise Rossato Silva

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Abstract

Background

Several studies to evaluate the accuracy of galactomannan (GM) in bronchoalveolar lavage fluid (BALF) as a diagnostic tool have been carried out; however, there are still controversies about the optimal cut-off point of BALF GM.

Aims

The objective of this study was to determine the diagnostic accuracy and the optimal cut-off point on BALF GM from patients with suspected invasive pulmonary aspergillosis (IPA) in a tertiary care hospital.

Methods

A cross-sectional study with 188 patients (≥18 years) that had undergone a bronchoscopy with BAL due to suspected IPA was carried out. IPA was diagnosed according to the EORTC/MSG guidelines.

Results

The optimal optical density cut-off point for BALF GM was 0.67, with sensitivity, specificity, positive predictive value, and negative predictive value of 100%, 70%, 32.3%, and 100%, respectively.

Conclusions

BALF GM detection proved to be a useful supplementary technique in the early diagnosis of IPA in both neutropenic and non-neutropenic patients.

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支气管肺泡灌洗液半乳甘露聚糖诊断疑似侵袭性肺曲霉病的准确性评价

背景:一些研究评估了半乳甘露聚糖(GM)在支气管肺泡灌洗液(BALF)中作为诊断工具的准确性;然而，BALF GM的最佳分界点仍存在争议。目的本研究的目的是确定三级医院疑似侵袭性肺曲霉病(IPA)患者BALF GM的诊断准确性和最佳分界点。方法对188例因怀疑IPA而行BAL支气管镜检查的患者(≥18岁)进行横断面研究。IPA是根据EORTC/MSG指南诊断的。结果BALF GM的最佳光密度截止点为0.67，敏感性为100%，特异性为70%，阳性预测值为32.3%，阴性预测值为100%。结论balf GM检测在中性粒细胞减少和非中性粒细胞减少患者IPA的早期诊断中是一种有用的辅助技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Iberoamericana De Micologia MYCOLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

81 days

期刊介绍： Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.