Drug-related problems among type II diabetes mellitus patients with hypertension: a cross-sectional study

J. Nzayisenga, Nicholas Njau Ngomi, J. Nyiligira
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引用次数: 2

Abstract

Introduction: Patients with type II diabetes mellitus (T2DM) and hypertension (HTN) are at increased threat for long experiencing various problems related to medicine as they frequently received different medications for managing their condition. Recently, there were no studies done locally on drug-related problems (DRPs) among T2DM patients with HTN. Thus, this study aims to assess the DRPs among T2DM patients with HTN admitted at Kibuye Referral Hospital (KRH). DRPs were drug safety problems, drug effectiveness problems and other drug problems. Methods: A retrospective cross-sectional study involved patients' files with T2DM and HTN, who were admitted at KRH from January 2013 to December 2017. The identification and classification of DRPs were based on pharmaceutical care network Europe (PCNE) classification system version 8.02. A simple random sampling technique was used to choose study participants from the target population. Data that met inclusion and exclusion criteria were analyzed using STATA version 13. The Fisher exact test (bivariate analysis) and logistic regression (multivariate) were used to test association and p-value ≤ 0.05 was considered as statistically significant. An adjusted odd ratio (AOR) with a confidence interval (CI) of 95% was determined using binary logistic regression. Results: Findings revealed that the prevalence of DRPs was 81.29% (313/385) and most of them each patient had at least two DRPs (69.05%). The patients aged above 55 years old were more likely to develop DRPs than those with age below 35 years (AOR = 1.2; P = 0.02; 95% CI: 0.2–2.3). Nevertheless, there was no significant association between DRPs and middle age (between 35 and 54 age of old). The patients who consumed more than or equal to 5 drugs were 2.4 times more likely to develop DRPs than those who took the number of medicines less than 5 (AOR = 15.4; P < 0.001; 95% CI: 8.8–26.8). Also, traditional medicines use ((AOR = 1.9; P = 0.016; 95% CI: 1.1–3.5) and having drug-related complication (AOR = 2.4; P < 0.001; 95% CI: 1.9–3) had shown significant associations. The total causes of DRPs identified were 1626 and most causes of DRPs were arisen from drug use (45.01%) and prescribing (37.83%). The drug/ dose selections were the most frequent causes of DRPs (36.97%). Conclusion: Since the prevalence of DRPs were relatively high, various factors influencing DRPs were established and most causes of DRPs were arising from drug use & drug prescribing among T2DM patients with HTN. Early detection needed to enhance patient’s life quality. Conducting studies in other hospitals needed to establish the national planning of DRPs to eradicate DRPs among patients T2DM with HTN.
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2型糖尿病合并高血压患者的药物相关问题:一项横断面研究
导论:2型糖尿病(T2DM)和高血压(HTN)患者长期经历各种药物相关问题的威胁增加,因为他们经常接受不同的药物来控制他们的病情。最近,国内没有关于T2DM合并HTN患者药物相关问题(DRPs)的研究。因此,本研究旨在评估Kibuye转诊医院(KRH)收治的T2DM合并HTN患者的DRPs。DRPs是药物安全问题、药物有效性问题和其他药物问题。方法:回顾性横断面研究纳入2013年1月至2017年12月在KRH住院的T2DM和HTN患者档案。drp的识别和分类基于欧洲药学服务网络(PCNE) 8.02版分类系统。采用简单的随机抽样技术从目标人群中选择研究参与者。符合纳入和排除标准的数据使用STATA version 13进行分析。采用Fisher精确检验(双变量分析)和logistic回归(多变量分析)检验相关性,以p值≤0.05为有统计学意义。采用二元逻辑回归确定校正奇数比(AOR),置信区间为95%。结果:调查结果显示,DRPs患病率为81.29%(313/385),其中大多数患者至少有2个DRPs(69.05%)。55岁以上的患者比35岁以下的患者更容易发生DRPs (AOR = 1.2;P = 0.02;95% ci: 0.2-2.3)。然而,DRPs与中年(35岁至54岁)之间没有显著关联。服用超过或等于5种药物的患者发生DRPs的可能性是服用药物少于5种的患者的2.4倍(AOR = 15.4;P < 0.001;95% ci: 8.8-26.8)。此外,传统药物使用(AOR = 1.9;P = 0.016;95% CI: 1.1-3.5)并有药物相关并发症(AOR = 2.4;P < 0.001;95% CI: 1.9-3)显示出显著的相关性。共发现DRPs原因1626例,其中用药(45.01%)和处方(37.83%)是导致DRPs的主要原因。药物/剂量选择是导致DRPs最常见的原因(36.97%)。结论:T2DM合并HTN患者DRPs患病率较高,影响DRPs的因素较多,DRPs的主要原因为用药和处方。早期发现有助于提高患者的生活质量。在其他医院开展研究需要建立全国性的drp计划,以根除T2DM合并HTN患者的drp。
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