Ziming Yang, S. Tong, Xu Sun, Shuang Yang, Shu Guo
{"title":"Novel frontiers for bone regeneration: application progress of mesenchymal stem cell-derived exosomes in bone tissue engineering","authors":"Ziming Yang, S. Tong, Xu Sun, Shuang Yang, Shu Guo","doi":"10.53388/lr20230004","DOIUrl":"https://doi.org/10.53388/lr20230004","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular mechanism of Compound Qingdai Capsule in the treatment of psoriasis based on network pharmacology and molecular docking","authors":"Min Li, D. Zhan, Xiaoqun Hu, Yu Wang, Zhou Zhou","doi":"10.53388/lr20230005","DOIUrl":"https://doi.org/10.53388/lr20230005","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Jiang, Gang Liu, Jing Ren, Yi Zhao, Huiwen Bai, Tuo Zhao, Lin Xu, Xiaohong Mu
{"title":"Systematic evaluation of the efficacy and safety of botulinum toxin type A in the treatment of spastic cerebral palsy","authors":"Yu Jiang, Gang Liu, Jing Ren, Yi Zhao, Huiwen Bai, Tuo Zhao, Lin Xu, Xiaohong Mu","doi":"10.53388/lr20230008","DOIUrl":"https://doi.org/10.53388/lr20230008","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jinwen Zhang, Xiaofei Ling, Yongzhong Cui, Hang Chen
{"title":"Current status and prospects of insect industrialization in China","authors":"Jinwen Zhang, Xiaofei Ling, Yongzhong Cui, Hang Chen","doi":"10.53388/lr20230010","DOIUrl":"https://doi.org/10.53388/lr20230010","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bishal Patangia, Anuradha Sathiyaseelan, Noel Singh Dias, A. M
{"title":"Occupational, environmental and psychosocial factors impacting reproductive health of women working in manufacturing sector in India: a systematic review","authors":"Bishal Patangia, Anuradha Sathiyaseelan, Noel Singh Dias, A. M","doi":"10.53388/lr20230007","DOIUrl":"https://doi.org/10.53388/lr20230007","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manuhar Sharma, Kushal Thakur, Sunil Kumar, Rakesh Kumar, Danish Mahajan, Bhavna Brar, D. Sharma, Amit Kumar Sharma
Indigenous peoples are the custodians of traditional knowledge, encompassing their ideas, innovations, and methods. Throughout history, both plants and animals have served as valuable sources for medicinal remedies, capable of treating or preventing illnesses. This article aims to offer a concise overview of the traditional medical uses of vertebrates and the derived products in both human and veterinary medicine. Animal species are utilized as raw materials, and the resulting products are employed to cure a wide array of ailments. In different regions of India, indigenous peoples have diverse traditional applications for vertebrates and their by-products, which are utilized to treat human and animal illnesses. In various parts of India, medical practices involve the use of forty percent mammals, seven percent birds, eleven percent reptiles, eight percent fish, and two percent amphibians. Kerala employs around 69 different animal species and their by-products for the treatment of human and veterinary ailments. Similarly, the Theni district of Tamil Nadu utilizes 69 animals, the state of Madhya Pradesh employs 18 animals, the state of Tripura utilizes 25 animals, and the state of Assam employs 44 animals for the treatment of human and veterinary illnesses. Consequently, the main objective of this review is to provide a summary of the traditional therapeutic applications of animals and the resulting products.
{"title":"Exploring the medicinal heritage: traditional applications of vertebrates and their by-products in human and veterinary remedies in India","authors":"Manuhar Sharma, Kushal Thakur, Sunil Kumar, Rakesh Kumar, Danish Mahajan, Bhavna Brar, D. Sharma, Amit Kumar Sharma","doi":"10.53388/lr20230014","DOIUrl":"https://doi.org/10.53388/lr20230014","url":null,"abstract":"Indigenous peoples are the custodians of traditional knowledge, encompassing their ideas, innovations, and methods. Throughout history, both plants and animals have served as valuable sources for medicinal remedies, capable of treating or preventing illnesses. This article aims to offer a concise overview of the traditional medical uses of vertebrates and the derived products in both human and veterinary medicine. Animal species are utilized as raw materials, and the resulting products are employed to cure a wide array of ailments. In different regions of India, indigenous peoples have diverse traditional applications for vertebrates and their by-products, which are utilized to treat human and animal illnesses. In various parts of India, medical practices involve the use of forty percent mammals, seven percent birds, eleven percent reptiles, eight percent fish, and two percent amphibians. Kerala employs around 69 different animal species and their by-products for the treatment of human and veterinary ailments. Similarly, the Theni district of Tamil Nadu utilizes 69 animals, the state of Madhya Pradesh employs 18 animals, the state of Tripura utilizes 25 animals, and the state of Assam employs 44 animals for the treatment of human and veterinary illnesses. Consequently, the main objective of this review is to provide a summary of the traditional therapeutic applications of animals and the resulting products.","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuan Wang, Bao-Liang Xu, Chun-Ming Dong, Yan-yan Sun
With the development of modern society, the demand for nutrition, health, and food safety among people is also increasing. More and more consumers are connecting their diet to a healthy lifestyle in order to reduce the occurrence of chronic diseases. Spirulina, known as green ginseng, is one of the most productive microalgae with high output value. It is considered as one of the most ideal dietary supplements due to its unique nutritional and health benefits. The main components of spirulina include protein, fat, vitamins, chlorophyll, and minerals. The protein content is particularly high, ranging from 60–70%. Spirulina can be used as a natural nutritional supplement, providing various essential nutrients needed by the body. Apart from being a nutritional supplement, spirulina is also widely utilized in the food, medicine, and cosmetics industries. Spirulina powder can be added to various foods such as bread, cakes, and biscuits to enhance their nutritional value. Spirulina extract can also be used in the production of healthcare and beauty products. Furthermore, the antioxidant and immune-boosting effects of spirulina make it a promising natural medicine for research in the treatment of cancer and liver disease. This paper aims to provide comprehensive information on the nutritional composition, secondary metabolites, and biological activities of spirulina, thereby contributing to the spirulina industry.
{"title":"The nutritional value of Spirulina and utilization research","authors":"Yuan Wang, Bao-Liang Xu, Chun-Ming Dong, Yan-yan Sun","doi":"10.53388/lr20230015","DOIUrl":"https://doi.org/10.53388/lr20230015","url":null,"abstract":"With the development of modern society, the demand for nutrition, health, and food safety among people is also increasing. More and more consumers are connecting their diet to a healthy lifestyle in order to reduce the occurrence of chronic diseases. Spirulina, known as green ginseng, is one of the most productive microalgae with high output value. It is considered as one of the most ideal dietary supplements due to its unique nutritional and health benefits. The main components of spirulina include protein, fat, vitamins, chlorophyll, and minerals. The protein content is particularly high, ranging from 60–70%. Spirulina can be used as a natural nutritional supplement, providing various essential nutrients needed by the body. Apart from being a nutritional supplement, spirulina is also widely utilized in the food, medicine, and cosmetics industries. Spirulina powder can be added to various foods such as bread, cakes, and biscuits to enhance their nutritional value. Spirulina extract can also be used in the production of healthcare and beauty products. Furthermore, the antioxidant and immune-boosting effects of spirulina make it a promising natural medicine for research in the treatment of cancer and liver disease. This paper aims to provide comprehensive information on the nutritional composition, secondary metabolites, and biological activities of spirulina, thereby contributing to the spirulina industry.","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jue Hu, Dan-Fei Chen, Fang-Fang Li, Nuo Chen, Chun-Lu Ye, Ke-Pin Yu, Xiaoyu Xuan, Gui-qi Xuan, Jing Chen
Background: To investigate the clinical medication approach of Professor Guiqi Xuan (Prof. Xuan) in treating pediatric patients with attention-deficit hyperactivity disorder (ADHD) and the potential mechanism of the core herbal prescription. Methods: Following medical record information pretreatment, the Traditional Chinese Medicine (TCM) inheritance computing platform system V3.0 was utilized to analyze the standardized data. The associate rules were summarized to identify the core prescription for treating ADHD. The extracted core herbal prescription’s active compounds and potential targets were used to establish a protein-protein interaction network of active ingredient-disease targets. Cytoscape 3.9.1 software was used to analyze the network’s topological parameters to obtain the key active ingredients and their targets. The Bioconductor data package of R4.0.2 was used to analyze the gene ontology biological functions and Kyoto Encyclopedia of Genes and Genomes pathways of key targets. Results: Two hundred and twenty-seven entries derived from TCM record information were selected. Through data mining, it was found that 62.5% of pediatric patients had short-tempered behavior, nearly half had sleep problems, and 30%–40% had picky eating and polyphagia issues. The highest-frequency syndrome type was kidney deficiency and liver hyperactivity. Deficiency, fire, phlegm, and dyspeptic food were the main pathological factors for ADHD. Prof. Xuan’s treatment of ADHD mainly focused on replenishing kidney essence and subduing Yang (active, external, ascending, warm, bright, functional and excited pertain to Yang). The core herbal prescription for ADHD included Yuan-zhi, Yi-zhi, Gui-jia, Bai-shao, Long-chi, Ci-shi, Shi-chang-pu, Yu-jin, Fu-shen, and Huang-jing. The protein-protein interaction network showed that MAOA, ADRB2, FOS, MAOB, and SLC6A3 were the five key targets essential in treating ADHD with core herbal prescriptions. The gene ontology biological function of crucial targets mainly involved G protein-coupled amine receptor activity, catecholamine binding, and neurotransmitter transmembrane transporter activity. Analysis of Kyoto Encyclopedia of Genes and Genomes pathways showed that the dopaminergic synapse signaling and neuroactive ligand-receptor interaction pathways were significantly enriched and may be the primary routes for the main treatment of ADHD. Conclusion: Prof. Xuan’s treatment of ADHD has achieved satisfactory clinical effects by supplementing the kidney, replenishing the essence, opening the orifices, nourishing the Yin (static, internal, descending, cold, dim, organic, depressed and pertain to Yin), and subduing the Yang. The major prescription predominantly affects catecholamine binding, neuroactive ligand-receptor interaction, G protein-coupled amine receptor function, and signaling pathways for dopaminergic synapses. Our findings showed that the methodology and software used in this research could explore and analyze the me
{"title":"A retrospective study on professor Gui-Qi Xuan’s experience in traditional Chinese medicine treatment on attention-deficit hyperactivity disorder: based on data mining and network pharmacology","authors":"Jue Hu, Dan-Fei Chen, Fang-Fang Li, Nuo Chen, Chun-Lu Ye, Ke-Pin Yu, Xiaoyu Xuan, Gui-qi Xuan, Jing Chen","doi":"10.53388/lr20230013","DOIUrl":"https://doi.org/10.53388/lr20230013","url":null,"abstract":"Background: To investigate the clinical medication approach of Professor Guiqi Xuan (Prof. Xuan) in treating pediatric patients with attention-deficit hyperactivity disorder (ADHD) and the potential mechanism of the core herbal prescription. Methods: Following medical record information pretreatment, the Traditional Chinese Medicine (TCM) inheritance computing platform system V3.0 was utilized to analyze the standardized data. The associate rules were summarized to identify the core prescription for treating ADHD. The extracted core herbal prescription’s active compounds and potential targets were used to establish a protein-protein interaction network of active ingredient-disease targets. Cytoscape 3.9.1 software was used to analyze the network’s topological parameters to obtain the key active ingredients and their targets. The Bioconductor data package of R4.0.2 was used to analyze the gene ontology biological functions and Kyoto Encyclopedia of Genes and Genomes pathways of key targets. Results: Two hundred and twenty-seven entries derived from TCM record information were selected. Through data mining, it was found that 62.5% of pediatric patients had short-tempered behavior, nearly half had sleep problems, and 30%–40% had picky eating and polyphagia issues. The highest-frequency syndrome type was kidney deficiency and liver hyperactivity. Deficiency, fire, phlegm, and dyspeptic food were the main pathological factors for ADHD. Prof. Xuan’s treatment of ADHD mainly focused on replenishing kidney essence and subduing Yang (active, external, ascending, warm, bright, functional and excited pertain to Yang). The core herbal prescription for ADHD included Yuan-zhi, Yi-zhi, Gui-jia, Bai-shao, Long-chi, Ci-shi, Shi-chang-pu, Yu-jin, Fu-shen, and Huang-jing. The protein-protein interaction network showed that MAOA, ADRB2, FOS, MAOB, and SLC6A3 were the five key targets essential in treating ADHD with core herbal prescriptions. The gene ontology biological function of crucial targets mainly involved G protein-coupled amine receptor activity, catecholamine binding, and neurotransmitter transmembrane transporter activity. Analysis of Kyoto Encyclopedia of Genes and Genomes pathways showed that the dopaminergic synapse signaling and neuroactive ligand-receptor interaction pathways were significantly enriched and may be the primary routes for the main treatment of ADHD. Conclusion: Prof. Xuan’s treatment of ADHD has achieved satisfactory clinical effects by supplementing the kidney, replenishing the essence, opening the orifices, nourishing the Yin (static, internal, descending, cold, dim, organic, depressed and pertain to Yin), and subduing the Yang. The major prescription predominantly affects catecholamine binding, neuroactive ligand-receptor interaction, G protein-coupled amine receptor function, and signaling pathways for dopaminergic synapses. Our findings showed that the methodology and software used in this research could explore and analyze the me","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current status and future challenges with Coronavirus (COVID-19): an update on vaccines","authors":"K. Rakesh, Shriya Gupta, Anant Gupta","doi":"10.53388/lr20230001","DOIUrl":"https://doi.org/10.53388/lr20230001","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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