First discovered positive effect of L-norvaline on the volume of small intestine tissues necrosis in a model of segmental mesenteric thrombosis in rats

Abstract

Introduction: Mesenteric thrombosis is a severe pathology with necrotization of intestinal tissues and death of the patient. The development of effective pharmacotherapy is an important task facing researchers. Materials and Methods: All studies were performed on 42 female white rats of the Wistar line, weighing 250±25 g. Segmental mesenteric thrombosis was reproduced by ligation of three segmental arteries in the area of the ileum. The volume of necrosis was determined by the triphenyl tetrazolium method. Results and Discussion: We have studied for the first time the effect of the arginase inhibitor L-norvaline on the volume of small intestine necrotized tissues in a model of acute segmental mesenteric thrombosis in rats. The study revealed a decrease in the volume of necrotic tissues from 32.39±0.47% to 23.84±0.39%, and the administration of glibenclamide did not cause complete cancellation of the L-norvaline action and led to a decrease in the volume of necrosis to 29.69±0.42%. Conclusion: Arginase inhibitor L-norvaline has protective effect in intestinal ischemia Graphical Abstract