Tocólisis con sulfato de magnesio o clorhidrato de isoxuprina en amenaza de parto pretérmino

Abstract

Objective

To compare the efficacy of intravenous magnesium sulphate with isoxsuprine hydrochloride in the treatment of threatened pre-term labour.

Materials and methods

A total of 82 patients with a gestational age between 24 and 34 weeks and threatened pre-term labour were selected to receive intravenous magnesium sulphate (Group A) or intravenous isoxsuprine hydrochloride (Group B). An analysis was performed on the time of ceasing of uterine contractions and maternal adverse effects.

Results

Tocolysis was successful in the first 24 hours in 61.0% of patients in Group A and 61.0% in patients of Group B (P = ns). After 7 days of treatment, 36.6% of patients in Group A and 36.6% of patients in Group B still were without contractions (P = ns). A delay in delivery over 34 weeks was obtained in 19.5% of patients treated with magnesium sulphate and 26.8% in patients treated with isoxsuprine hydrochloride (P = ns). Nausea, tremor, and vomiting were more frequent in Group A, while tremors and sweating were more frequent in Group B (P = ns).

Conclusion

Magnesium sulphate is as effective as isoxsuprine hydrochloride for tocolysis in threatened pre-term labour.