Utilidad diagnóstica del biomarcador relación plaquetas-linfocitos en rotura prematura de membranas de término y pretérmino

Abstract

Introduction

The rupture of membranes increases perinatal morbidity and mortality due to the risk of chorioamnionitis, prematurity, respiratory distress syndrome, among others, for both the mother and foetus. The platelet-to-lymphocyte ratio has been previously used as an inflammatory biomarker in various pathologies, including the pre-term premature rupture of membranes.

Materials and methods

A retrospective, descriptive, and observational, case-control study was conducted on 206 pregnant patients over 22 weeks of gestational age with rupture of membranes (at term and pre-term). A control group included 93 patients with a diagnosis of cephalopelvic disproportion without any other pathology that were interrupted at the Hospital Angeles Pedregal, Mexico, from 2012 to 2017.

Results

The platelet-to-lymphocyte ratio was calculated in these patient groups, and was found to be statistically significantly elevated in the group with pre-term premature rupture of membranes compared to the control group. A tendency for a higher platelet count was found in patients with rupture of membranes at both pre-term and at term, and statistically significant when compared to the control group.

Conclusions

The results in this study are of great importance due to the diagnostic use of an accessible and low-cost test such as the biometric blood test used to calculate de platelet-to-lymphocyte ratio in patients with pre-term premature rupture of membranes.