{"title":"Immunometabolism of different T cell subsets during sepsis","authors":"Pinhao Guo, Lulong Bo","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.02.019","DOIUrl":null,"url":null,"abstract":"Aberrant activation of innate immune cells and immunosuppression are part of the pathogenesis of sepsis. The loss of CD4+ T cells, CD8+ T cells, Th17 cells, γδT cells, upregulation of regulatory T cells (Tregs) and aberrant immune cell metabolism can be detected in the stage of immunosuppression. Summarizing and analyzing the influence of immunometabolism of immune cells (CD4+ T cells, CD8+ T cells, Th17, Tregs and γδT) during sepsis-induced immunosuppression on regulating the function of T cells are helpful to investigate potential target of the immunometabolism of T cells. This review is benefit to explore novel immunometabolism therapeutic method to treat sepsis. \n \n \nKey words: \nSepsis; Immunosuppression; Immunometabolism; T cells","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"212-216"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际麻醉学与复苏杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.02.019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Aberrant activation of innate immune cells and immunosuppression are part of the pathogenesis of sepsis. The loss of CD4+ T cells, CD8+ T cells, Th17 cells, γδT cells, upregulation of regulatory T cells (Tregs) and aberrant immune cell metabolism can be detected in the stage of immunosuppression. Summarizing and analyzing the influence of immunometabolism of immune cells (CD4+ T cells, CD8+ T cells, Th17, Tregs and γδT) during sepsis-induced immunosuppression on regulating the function of T cells are helpful to investigate potential target of the immunometabolism of T cells. This review is benefit to explore novel immunometabolism therapeutic method to treat sepsis.
Key words:
Sepsis; Immunosuppression; Immunometabolism; T cells
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
