The Effects of Punica granatum Flower Extract on Skin Injuries Induced by Burn in Rats

Q1 Pharmacology, Toxicology and Pharmaceutics Advances in Pharmacological Sciences Pub Date : 2017-01-19 DOI:10.1155/2017/3059745

E. Nasiri, S. Hosseinimehr, J. Akbari, M. Azadbakht, S. Azizi

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引用次数: 32

Abstract

Background. We compared the efficacy of P. granatum (P) flower extract with that of silver sulfadiazine (SSD) for treating thermal burn injuries in rats. Methods. Ten Wistar rats in each group were topically given base cream, normal saline, cream containing 1% SSD, or creams containing 5% or 10% Punica granatum flower extract. The treatments were administered once daily until complete wound healing was observed. The wound area and healing time were assessed. In addition, percentage wound contraction and histopathological characteristics such as neovascularization and collagen formation were determined. The tannin content in P. granatum extract was determined. Results. The decrease in the average size of wounds on day 15 of the treatment was higher in rats treated with creams containing P. granatum extract than in rats treated with cream containing SSD (2.8 ± 0.9 cm2 versus 8.4 ± 3.2 cm2). The wounds completely healed on day 25 of the treatment in rats treated with creams containing P. granatum flower extract compared with those in rats treated with the other agents. Conclusion. These results indicated that P. granatum flower extract promoted wound healing in rats and could be used for managing burn injuries.

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石榴花提取物对大鼠烧伤皮肤损伤的影响

背景。比较了石榴花提取物和磺胺嘧啶银提取物对大鼠热烧伤的治疗作用。方法。每组10只Wistar大鼠局部给予基础乳膏、生理盐水、含1% SSD乳膏或含5%或10%石榴花提取物乳膏。每天治疗一次，直至观察到伤口完全愈合。评估创面面积及愈合时间。此外，还测定了伤口收缩百分比和组织病理学特征，如新生血管和胶原形成。测定了石榴提取物中单宁的含量。结果。在治疗的第15天，用含有石榴提取物的乳膏处理的大鼠伤口的平均大小比用含有SSD的乳膏处理的大鼠减少(2.8±0.9 cm2比8.4±3.2 cm2)。与用其他药剂处理的大鼠相比，用含有石榴花提取物的药膏处理的大鼠伤口在治疗的第25天完全愈合。结论。上述结果表明，石榴花提取物具有促进大鼠创面愈合的作用，可用于烧伤治疗。

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来源期刊

Advances in Pharmacological Sciences PHARMACOLOGY & PHARMACY-

CiteScore

6.40

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： Advances in Pharmacological and Pharmaceutical Sciences is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of experimental and clinical pharmacology, pharmaceutics, medicinal chemistry and drug delivery. Topics covered by the journal include, but are not limited to: -Biochemical pharmacology, drug mechanism of action, pharmacodynamics, pharmacogenetics, pharmacokinetics, and toxicology. -The design and preparation of new drugs, and their safety and efficacy in humans, including descriptions of drug dosage forms. -All areas of medicinal chemistry, such as drug discovery, design and synthesis. -Basic biology of drug and gene delivery through to application and development of these principles, through therapeutic delivery and targeting. Areas covered include bioavailability, controlled release, microcapsules, novel drug delivery systems, personalized drug delivery, and techniques for passing biological barriers.