EFFICACY OF AMOXICILLIN (ATCOMOX®) AND/OR ALLICIN ON PERFORMANCE, HAEMATOLOGICAL, BIOCHEMICAL, AND HISTOPATHOLOGICAL CHANGES IN Clostridium perfringens INFECTED CHICKENS

Abstract

The efficacy of amoxicillin and/or allicinin healthy and experimentally Clostridium perfringens-infected broiler chickens was investigated. The chicks were equally divided into six groups, and all medications were orally administered via drinking water for five consecutive days: Group 1: non-infected and non-treated; Group 2: infected and non-treated; Group 3: infected and amoxicillin-treated (20 mg/kg b.wt); Group 4: infected and allicin-treated (25 mg/kg b.wt); Group 5: infected and treated with amoxicillin (20 mg/kg b.wt) and allicin (25 mg/kg b.wt); Group 6: infected and treated with amoxicillin (10 mg/kg b.wt) and allicin (25 mg/kg b.wt). Growth performance,haematological andbiochemical parameters were recorded. Significant decreases in total protein, albumin, RBCs, Hb, andPCV and a considerable increase in WBCs, AST, ALT, ALP, creatinine, anduric acid in infected chickens were observed. Administration amoxicillin and/or allicin for treatment of Clostridium perfringens infection resulted in improvement in haematological and biochemical changes following infection. A dose of amoxicillin (10 mg) and allicin (25 mg)/kg bwt for treatment of Clostridium perfringens infection in broiler chickens is recommended due to great synergistic effect, reduced mortality, greater safety, and increased economic potential. Key words: amoxicillin; allicin; efficacy; broilers; biochemical; hematological VPLIV AMOXICILINA (ATCOMOX®) IN ALICINA NA PRIRAST, HEMATOLOSKE, BIOKEMIJSKE IN HISTOPATOLOSKE SPREMEMBE PRI PISCANCIH, OKUŽENIH S Clostridium perfringens Povzetek: V studiji smo ugotavljali ucinkovitost amoksicilina in/ali alicinina pri zdravih pitovnih piscancih in pitovnih piscancih poskusno okuženimih z bakterijo Clostridium perfringens . Piscanci so bili razdeljeni v sest skupin in so zdravila dobivali peroralno preko vode pet dni zapored. V prvi skupini so bili neokuženi in nezdravljeni piscanci, v drugi okuženi in nezdravljeni, v tretji okuženi in zdravljeni z amoksicilinom (20 mg/kg telesne mase), v cetrti skupini okuženi in zdravljeni z alicinom (25 mg/kg telesne mase) v peti skupini okuženi in zdravljeni z amoksicilinom (20 mg/kg teže) in alicinom (25 mg/kg telesne mase) in v sesti skupini okuženi in zdravljeni z amoksicilinom (10 mg/kg teže) in alicinom (25 mg/kg telesne mase). Spremljali smo prirast piscancev ter njihove hematoloske in biokemicne parametre. Pri okuženih piscancih smo v krvi opazili znatno znižanje skupnih beljakovin, albuminov, RBC, Hb in PCV ter znatno povecanje WBC, AST, ALT, ALP, kreatinina in secne kisline. Uporaba amoksicilina in/ali alicina za zdravljenje okužbe s Clostridium perfringens je povzrocila izboljsanje hematoloskih in biokemicnih sprememb po okužbi. Odmerek amoksicilina 10 mg/kg in alicina 25 mg/kg telesne mase za zdravljenje okužbe s Clostridium perfringens pri pitovnih piscancih brojlerjih se je izkazal kot najbolj ucinkovit, verjetno zaradi sinergisticnega ucinka obeh zdravil, in je povzrocil zmanjsanje smrtnosti pitovnih piscancev. Kljucne besede: amoksicilin; alicin; ucinkovitost; brojlerji; biokemjski parametri; hematoloski parametri