Engineering the native methylotrophs for the bioconversion of methanol to value-added chemicals: current status and future perspectives

IF 9.1 Q1 ENGINEERING, CHEMICAL Green Chemical Engineering Pub Date : 2023-06-01 DOI:10.1016/j.gce.2022.10.005
Jing Wang, Ruirui Qin, Yuanke Guo, Chen Ma, Xin Wang, Kequan Chen, Pingkai Ouyang
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引用次数: 5

Abstract

Methanol is becoming an attractive fermentation feedstock for large-scale bioproduction of chemicals, due to its natural abundance and mature production technology. Native methylotrophs, which can utilize methanol as the only source of carbon and energy, are ideal hosts for methanol bioconversion due to their high methanol utilization rate and have been extensively employed in the production of value-added chemicals from methanol. Here, we review the natural methanol utilization pathways in native methylotrophs, describing the available synthetic biology tools developed for engineering native methylotrophs, and discuss the strategies for improving their methanol utilization efficiency. Finally, the representative examples of engineering the native methylotrophs to produce value-added products from methanol are summarized. Furthermore, we also discuss the major challenges and possible solutions for the application of native methylotrophs in methanol-based biomanufacturing.

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甲醇生物转化为增值化学品的天然甲基化营养体工程:现状和未来展望
甲醇由于其天然的丰富性和成熟的生产技术,正在成为大规模生物化工生产的一种有吸引力的发酵原料。天然甲基营养物可以利用甲醇作为唯一的碳和能源来源,由于其甲醇利用率高,是甲醇生物转化的理想宿主,并已被广泛用于从甲醇生产增值化学品。在这里,我们回顾了天然甲基营养体中的天然甲醇利用途径,描述了为工程天然甲基营养物开发的可用合成生物学工具,并讨论了提高其甲醇利用效率的策略。最后,总结了利用甲醇改造天然甲基营养物生产高附加值产品的代表性实例。此外,我们还讨论了天然甲基营养物在甲醇生物制造中应用的主要挑战和可能的解决方案。
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来源期刊
Green Chemical Engineering
Green Chemical Engineering Process Chemistry and Technology, Catalysis, Filtration and Separation
CiteScore
11.60
自引率
0.00%
发文量
58
审稿时长
51 days
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