Actinomycin D as an Epimutagen in Protists

IF 1.5 4区 生物学 Q4 MICROBIOLOGY Acta Protozoologica Pub Date : 2017-12-13 DOI:10.4467/16890027AP.17.012.7493
Z. I. Uspenskaya, A. L. Yudin
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Abstract

A previously unrecorded property of actinomycin D, a well-known antibiotic, was discovered in the course of long-term genetic research on the amoeba Amoeba proteus and the ciliate Dileptus anser. In these protists actinomycin D can induce an unusual type of hereditary variation, which we refer to as the inheritable destabilization of characters. A number of features indicate that this variation is epigenetic, that is, not caused by mutations in the DNA. Therefore, actinomycin D may be considered as an inducer of epigenetic inheritable changes, in other words, as an epimutagen.
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放线菌素D作为蛋白质表观诱变剂
放线菌素D是一种众所周知的抗生素,在对变形虫变形虫和纤毛虫Dileptus的长期遗传研究中发现了一种以前未被记录的特性。在这些原生生物中,放线菌素D可以诱导一种不寻常的遗传变异,我们称之为性状的遗传不稳定。许多特征表明这种变异是表观遗传的,也就是说,不是由DNA突变引起的。因此,放线菌素D可能被认为是一种表观遗传变化的诱导剂,换句话说,是一种表观诱变剂。
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来源期刊
Acta Protozoologica
Acta Protozoologica 生物-微生物学
CiteScore
2.00
自引率
0.00%
发文量
8
审稿时长
>12 weeks
期刊介绍: Acta Protozoologica - International Journal on Protistology - is a quarterly journal that publishes current and comprehensive, experimental, and theoretical contributions across the breadth of protistology, and cell biology of Eukaryote microorganisms including: behaviour, biochemistry and molecular biology, development, ecology, genetics, parasitology, physiology, photobiology, systematics and phylogeny, and ultrastructure. It publishes original research reports, critical reviews of current research written by invited experts in the field, short communications, book reviews, and letters to the Editor.
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