Nasser Mohammed Hosny, Heba M. Mahmoud, Mohamed H. Abdel-Rhman
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引用次数: 15
Abstract
The ligand N-(2-isonicotinoylhydrazine-carbonothioyl)benzamide (H3L) and its metal complexes with Co(II), Ni(II), Cu(II), and Zn(II) acetates have been synthesized. The synthesized compounds have been characterized by elemental analyses, FT-IR, UV-Visible spectra, 1H-NMR, 13C-NMR, ESR, MS, effective magnetic moments, molar conductance, and thermal analyses. The free organic ligand exists in the keto form, but in the metal complexes, it forms chelates with the metal ions in the enol form. The measured optical band gap (Eg) values confirmed the presence of direct electronic transition and the semiconductivity of the current compounds. The ligand and its Zn(II) complex were examined as cytotoxic agents against HePG-2 and HCT-116 and showed. H3L exhibited strong cytotoxicity, while Zn complex showed moderate activity.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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