Oculomotor abnormalities during reading in offspring of late-onset Alzheimer's disease.

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Current Alzheimer research Pub Date : 2022-04-13 DOI:10.2174/1567205019666220413075840
G. Fernández, Ana Paula González, C. Abulafia, L. Fiorentini, Osvaldo Agamennoni, S. Guinjoan
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Abstract

INTRODUCTION Eye movement patterns during reading are well defined and documented. Each eye movement ends up in a fixation point, which allows the brain to process the incoming information and to program the following saccade. In this work, we investigated whether eye movement alterations during a reading task might be already present in middle-aged, cognitively normal offspring of late-onset Alzheimer's disease (O-LOAD). METHODS 18 O-LOAD and 18age-matched healthy individuals with no family history of LOAD participated in the study. Participants were seated in front of a 20-inch LCD monitor and single sentences were presented on it. Eye movements were recorded with an eye tracker, with a sampling rate of 1000 Hz. RESULTS Analysis of eye movements during reading revealed that O-LOAD displayed more fixations, shorter saccades and shorter fixation durations than controls. CONCLUSION The present study shows that O-LOAD evidenced alterations in their eye movements during reading. O-LOAD eye movement behavior could be considered an initial sign of oculomotor impairment. Hence, evaluation of eye movement during reading might provide a useful tool for monitoring well-defined cognitive resources.
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迟发性阿尔茨海默病后代阅读时的动眼肌异常。
引言阅读过程中的眼动模式有很好的定义和记录。每一次眼球运动都以一个注视点结束,这使大脑能够处理传入的信息并对接下来的扫视进行编程。在这项工作中,我们调查了阅读任务中的眼动变化是否已经存在于晚发性阿尔茨海默病(O-LOAD)的中年、认知正常的后代中。方法18名O-LOAD和18岁匹配的健康人参与了这项研究,他们没有LOAD家族史。参与者坐在一个20英寸的液晶显示器前,在显示器上显示单句。用眼动仪记录眼球运动,采样率为1000赫兹。结果对阅读过程中的眼球运动进行分析显示,O-LOAD比对照组表现出更多的注视、更短的扫视和更短的注视持续时间。结论本研究表明,O-LOAD可以证明他们在阅读过程中的眼动发生了变化。O-LOAD眼动行为可被认为是动眼器损伤的最初迹象。因此,评估阅读过程中的眼动可能为监测定义明确的认知资源提供有用的工具。
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来源期刊
Current Alzheimer research
Current Alzheimer research 医学-神经科学
CiteScore
4.00
自引率
4.80%
发文量
64
审稿时长
4-8 weeks
期刊介绍: Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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