Circadian melatonin profile in opium and amphetamine dependent patients: A preliminary study

Q2 Medicine Neurobiology of Sleep and Circadian Rhythms Pub Date : 2019-11-01 DOI:10.1016/j.nbscr.2019.100046

Habibolah Khazaie MD , Hamid Reza Ahmadi MD , Amir Kiani PhD , Mohammad Rasoul Ghadami MD

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引用次数: 2

Abstract

Aim

The aim of this study was to investigate the relationship between opium and amphetamine dependency with the serum melatonin levels in the presence of circadian rhythm sleep disorders (CRSD).

Participants

Forty four male amphetamine-dependent and opium-dependent patients with CRSD and with more than one year substance dependency were enrolled in this study. Control group consisted of twelve healthy male subjects.

Design

The diagnoses of sleep disorders were established by a psychiatrist and were made on the basis of the criteria of ICSD-II using the patients’ sleep logs. Blood samples were drawn every 4 h through an intravenous catheter. Serum melatonin levels were assayed using an enzyme-linked immunosorbent assay (ELISA) kit. Repeated Measures Analysis of variance (ANOVA) was used to assess differences between the melatonin levels at six separate times.

Finding

The serum melatonin levels of the control subjects were significantly higher than both opium-dependent and amphetamine-dependent patients at 24:00, 4:00 and 8:00. The serum melatonin level of the opium-dependent patients were significantly lower than the amphetamine-dependent patients at 24:00 (26.9 ± 11.4 vs. 41 ± 19.4, respectively; p = 0.006) and were significantly higher than the amphetamine-dependent patients at 16:00 (12.7 ± 5.1 vs. 8.9 ± 4.1, respectively; p = 0.011).

Conclusion

This is an evidence of negative effects of substance dependence on circadian cycle of melatonin secretion among opium and amphetamine dependent patients.

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鸦片和安非他明依赖患者的昼夜褪黑激素特征:初步研究

目的探讨在存在昼夜节律睡眠障碍(CRSD)的情况下，鸦片和安非他命依赖与血清褪黑激素水平的关系。研究对象:44名男性非安非他明依赖和阿片依赖的CRSD患者和超过一年的物质依赖被纳入本研究。对照组为12名健康男性。设计由精神科医生根据ICSD-II的标准，根据患者的睡眠记录，对睡眠障碍进行诊断。通过静脉导管每4 h抽取一次血样。采用酶联免疫吸附测定(ELISA)试剂盒检测血清褪黑素水平。使用重复测量方差分析(ANOVA)来评估六个不同时间褪黑激素水平之间的差异。结果:对照受试者血清褪黑素水平在24:00、4:00和8:00均显著高于鸦片依赖组和安非他明依赖组。阿片依赖患者血清褪黑素水平在24:00时显著低于安非他明依赖患者(26.9 ± 11.4 vs. 41 ± 19.4);P = 0.006)，且在16:00时显著高于安非他明依赖患者(分别为12.7 ± 5.1 vs. 8.9 ± 4.1; = 0.011页)。结论鸦片和安非他明依赖患者的褪黑激素昼夜周期受到物质依赖的负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Sleep and Circadian Rhythms Neuroscience-Behavioral Neuroscience

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

69 days

期刊介绍： Neurobiology of Sleep and Circadian Rhythms is a multidisciplinary journal for the publication of original research and review articles on basic and translational research into sleep and circadian rhythms. The journal focuses on topics covering the mechanisms of sleep/wake and circadian regulation from molecular to systems level, and on the functional consequences of sleep and circadian disruption. A key aim of the journal is the translation of basic research findings to understand and treat sleep and circadian disorders. Topics include, but are not limited to: Basic and translational research, Molecular mechanisms, Genetics and epigenetics, Inflammation and immunology, Memory and learning, Neurological and neurodegenerative diseases, Neuropsychopharmacology and neuroendocrinology, Behavioral sleep and circadian disorders, Shiftwork, Social jetlag.