Expression and significance of Bone Morphogenetic Protein 2 and phosphatase and tensin homolog deleted on chromosome ten in incipient, recurrent and malignant salivary gland pleomorphic adenoma
Guan′e Li, Xinhao Fan, Hai-yan Li, Zhen-Zhen Dai, Jinyuan Li
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Abstract
Objective
To investigate the expression and significance of bone morphogenetic protein-2 (BMP-2) and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in incipient, recurrent and malignant salivary gland pleomorphic adenoma.
Methods
A total of 93 cases of salivary gland pleomorphic adenoma in Kailuan general hospital from 2008 to 2017 were collected, including 54 in incipient group (group A, 47 cases in benign group A1, 7 cases in malignant group A2), 39 cases in recurrent group (group B, 26 cases in benign group B1, 13 cases in malignant group B2). The expression of BMP-2 and PTEN were detected by immunohistochemical detection and western blot, the correlation of BMP-2 and PTEN was analyzed by Spearman analysis.
Results
The immunohistochemical and western blot analysis both showed expression of BMP-2 in recurrent group was significantly higher than that in incipient cases((129.03±15.52) vs.(87.88±18.11), t=-8.094, P=0.000), and it was lower in malignant cases than that in benign cases((100.24±25.07) vs (116.66±26.19), t=2.125, P=0.040). There was no significant difference in PTEN expression between incipient and recurrent groups((89.15±13.92) vs.(96.19±28.02), t=1.055, P=0.279), but lower PTEN expression was found in malignant cases than benign cases((76.06±11.16) vs.(109.28±17.05), t=7.543, P=0.000). BMP-2 was positively correlated with PTEN expression (r=0.313, P<0.05).
Conclusion
BMP-2 is associated with the recurrence of salivary gland pleomorphic adenoma, and both BMP-2 and PTEN are associated with malignant in the salivary gland pleomorphic adenoma.
Key words:
Pleomorphic adenoma; Bone morphogenetic protein 2; Phosphatase and tensin homolog deleted on chromosome ten; Immunohistochemisty; Apoptosis
期刊介绍：
Clinical Medicine of China is an academic journal organized by the Chinese Medical Association (CMA), which mainly publishes original research papers, reviews and commentaries in the field.
Clinical Medicine of China is a source journal of Peking University (2000 and 2004 editions), a core journal of Chinese science and technology, an academic journal of RCCSE China Core (Extended Edition), and has been published in Chemical Abstracts of the United States (CA), Abstracts Journal of Russia (AJ), Chinese Core Journals (Selection) Database, Chinese Science and Technology Materials Directory, Wanfang Database, China Academic Journal Database, JST Japan Science and Technology Agency Database (Japanese) (2018) and other databases.
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