HSP90 Inhibition Enhances the Anti-Tumor Efficacy of Combination Chemo Immunotherapy Targeting DNA Repair Proteins

MOJ immunology Pub Date : 2017-10-23 DOI:10.15406/MOJI.2017.05.00181

Subhara Raveendran, Ronald J Fecek, Micah Brown, K. Fabian, Jennifer L. Taylor, C. Carey, W. Storkus

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Abstract

Submit Manuscript | http://medcraveonline.com Abbreviations: ACT: Adoptive Cellular Therapy; ATM: Ataxia Telangiectasia Mutated Protein; ATR: ATM and Rad3-Related Protein; BRAF: B-Raf proto-oncogene; BRCA: Breast Cancer; CFDA-SE: Carboxy Fluorescein Diacetate Succinimidyl Ester; CFSE: Carboxy Fluorescein Succinimidyl Ester; CHEK: Checkpoint kinase; CM: Culture Medium; CTLA-4: Cytotoxic TLymphocyte Associated protein 4; DC: Dendritic Cell; DNA-RP: DNA Repair Proteins; DMSO: Dimethyl Sulfoxide; DOX: Doxorubicin; ELISA: Enzyme-Linked Immuno Sorbent Assay; FMOC: Fluorenyl Methoxy Carbonyl; HDAC: Histone Deacetylase; HIP: Hsp70 Interacting Protein; HOP: Hsp70-Hsp90 Organizing Protein; HSP: Heat Shock Protein; HSP90i: HSP90 Inhibitor; DSB: Double-Strand Breaks; IFN: Interferon; IL: Interleukin; MACS: Magnetic-Activated Cell Sorting; MART1: Melanoma Antigen Recognized by T cells 1; MHC: Major Histo Compatibility; MRE 11: Meiotic Recombination Protein 11; MRN: MRE11–RAD50–NBS1, NBN: Nibrin; PD1: Programmed Cell Death Protein 1; PD-L1: Programmed DeathLigand 1; PRKDC: Protein kinase DNA-activated Catalytic polypeptide; QPCR: Quantitative Polymerase Chain Reaction; SDS-PAGE: Sodium Dodecyl Sulphate-Polyacrylamide Gel Electrophoresis; TIL: Tumor-Infiltrating Lymphocytes; TME: Tumor Microenvironment; TMZ: Temozolomide; TRP: Tyrosinase Related Protein; TUNEL: Terminal Deoxynucleotidyl Transferase dUTP Nick End Labeling

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抑制HSP90增强靶向DNA修复蛋白的联合化疗免疫治疗的抗肿瘤效果

投稿| http://medcraveonline.com缩写:ACT:过继细胞疗法;ATM:共济失调毛细血管扩张突变蛋白;ATR: ATM和rad3相关蛋白;BRAF: B-Raf原癌基因;BRCA:乳腺癌;CFDA-SE:羧基荧光素二醋酸琥珀酰亚基酯;羧基荧光素琥珀酰氨基酯;check:检查点激酶;CM:培养基;CTLA-4:细胞毒性t淋巴细胞相关蛋白4;DC:树突状细胞;DNA- rp: DNA修复蛋白;DMSO:二甲基亚砜;阿霉素:阿霉素;ELISA:酶联免疫吸附试验;氟烯基甲氧基羰基;组蛋白去乙酰化酶;HIP: Hsp70相互作用蛋白;HOP: Hsp70-Hsp90组织蛋白;热休克蛋白;HSP90i: HSP90抑制剂;DSB:双链断裂;干扰素:干扰素;IL:白介素;MACS:磁活化细胞分选;MART1: T细胞识别黑色素瘤抗原1;MHC:主要组织相容性;MRE 11:减数分裂重组蛋白11;MRN: MRE11-RAD50-NBS1, NBN: Nibrin;PD1:程序性细胞死亡蛋白1;PD-L1:程序化死亡配体1;PRKDC:蛋白激酶dna活化催化多肽;定量聚合酶链反应;SDS-PAGE:十二烷基硫酸钠-聚丙烯酰胺凝胶电泳;TIL:肿瘤浸润淋巴细胞;TME:肿瘤微环境;TMZ: Temozolomide;TRP:酪氨酸酶相关蛋白;末端脱氧核苷酸转移酶dUTP末端标记

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MOJ immunology

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