Pouya Safarzadeh Kozani, Pooria Safarzadeh Kozani, R. O’Connor
{"title":"Humanized Chimeric Antigen Receptor (CAR) T cells","authors":"Pouya Safarzadeh Kozani, Pooria Safarzadeh Kozani, R. O’Connor","doi":"10.33696/cancerimmunol.3.055","DOIUrl":null,"url":null,"abstract":"T cells to unique antigens, the T-cell activation in a major complex chimeric as of the antigen recognition moiety to a single-chain variable fragment domain (scFv) and it the ζ chain of the TCR/CD3 modular recombinant, the intracellular CD3 ζ to T-cell activation following antigen engagement. it the origin of the chimeric antigen receptors (CARs) used clinically to of this very that CD3 with CD3 or growth factor receptor-bound protein optimal structural reconfigurations","PeriodicalId":73633,"journal":{"name":"Journal of cancer immunology","volume":"3 1","pages":"183 - 187"},"PeriodicalIF":0.0000,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of cancer immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33696/cancerimmunol.3.055","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
T cells to unique antigens, the T-cell activation in a major complex chimeric as of the antigen recognition moiety to a single-chain variable fragment domain (scFv) and it the ζ chain of the TCR/CD3 modular recombinant, the intracellular CD3 ζ to T-cell activation following antigen engagement. it the origin of the chimeric antigen receptors (CARs) used clinically to of this very that CD3 with CD3 or growth factor receptor-bound protein optimal structural reconfigurations
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