Nonspecific Energy Expenditure of the Body and Body Mass Regulation

P. P. Zagoskin
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Abstract

The principal possibility of nonspecific energy expenditure at all stages of the transformation of nutrients in the body is demonstrated. These stages include the processing of food in the mouth, digestion, absorption, interaction with the intestinal micro biome, and interstitial metabolic processes. Particular attention is paid to the role of nonspecific energy expenditure of the body in the regulation of body mass. The data on the pivotal role of reducing nonspecific energy expenditure in the development of obesity and associated pathological conditions are presented. The prospects for using uncouples of oxidative phosphorylation, fatty acids, carnitine, bile acids, sarcolipin and a number of other substances as regulators of the nonspecific energy expenditure and potential means of preventing and treating obesity are analyzed.
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身体的非特异性能量消耗与身体质量调节
证明了在体内营养物质转化的所有阶段出现非特异性能量消耗的主要可能性。这些阶段包括食物在口腔中的加工、消化、吸收、与肠道微生物群落的相互作用以及间质代谢过程。特别注意身体的非特异性能量消耗在调节体重中的作用。介绍了减少非特异性能量支出在肥胖和相关病理条件发展中的关键作用的数据。分析了利用氧化磷酸化、脂肪酸、肉毒碱、胆汁酸、肌脂蛋白和其他一些物质的解偶联物作为非特异性能量消耗的调节剂和预防和治疗肥胖的潜在手段的前景。
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