Xylopic acid Suppresses Adjuvant-induced Arthritis in Sprague Dawley rats via Reduction in Serum Levels of IL-6 And TNF-alpha.

Q2 Medicine Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pub Date : 2022-03-10 DOI:10.2174/1871523021666220310094218

Newman Osafo, A. Antwi, Sarah Otu-Boakye

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引用次数: 1

Abstract

BACKGROUND Xylopic acid (XA) is the principal constituent obtained from the biofractionation of the dried fruits of Xylopia aethiopica. Our initial reports have established the acute anti-inflammatory activity of this kaurene diterpene. OBJECTIVE Currently, we investigate the chronic anti-inflammatory activity of xylopic acid. METHOD The adjuvant-induced arthritis model in rats was employed in carrying out the study. RESULTS It was observed from the study that XA significantly (P < 0.05) suppressed the oedema associated with adjuvant arthritis while preventing associated joint deformation as identified from the radiographs. Histopathological analysis of joints of treated animals revealed signs of bone reformation and re-calcification following XA administration. From the haematological analysis, xylopic acid significantly decreased eosinophil sedimentation rate (ESR) while also decreasing white blood cells (WBC) which was increased after arthritis induction. Serum analysis showed the inhibitory effect of XA on serum expression of IL-6 and TNF-alpha in arthritic rats. CONCLUSION Our study demonstrates the anti-arthritic activity of orally administered XA while pointing to a possible mechanism of its anti-inflammatory action.

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木香酸通过降低血清IL-6和tnf - α水平抑制佐剂诱导的大鼠关节炎。

背景:木酸(XA)是由埃塞俄比亚木(Xylopia aethiopica)干果生物分离得到的主要成分。我们的初步报告已经确定了这种珈烯二萜的急性抗炎活性。目的研究木香酸的慢性抗炎作用。方法采用佐剂诱导大鼠关节炎模型进行研究。结果从x线片上观察到XA显著(P < 0.05)抑制佐剂性关节炎相关水肿，同时防止相关关节变形。治疗动物关节的组织病理学分析显示XA给药后骨重建和再钙化的迹象。从血液学分析，木酸显著降低嗜酸性粒细胞沉降率(ESR)，同时也降低白细胞(WBC)，而白细胞在关节炎诱导后增加。血清分析显示XA对关节炎大鼠血清中IL-6和tnf - α的表达有抑制作用。结论口服XA具有抗关节炎的作用，并提示其抗炎作用的可能机制。

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来源期刊

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.30

自引率

0.00%

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期刊介绍： Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-inflammatory & anti-allergy agents. Publishing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.