HEPATO-PATHOLOGICAL STUDY OF THE REHABILITATIVE POTENTIALS OF JAMBUL (Syzygium cumini) PLANT EXTRACT IN LEAD INTOXICATED MICE

Abstract

The ameliorative prospective of Jambul (Syzygium cumini) fruit pulp extract was studied against Pb-based hepato-histological and micrometric changes in albino laboratory mice (Mus musculus). There were 3 experimental groups: (i) Control group (untreated) (ii) Pb group (15 days 50ppm Pb ions from Lead acetate in drinking water (iii) Pb+Jm group (Pb ions treatment as in Pb group followed by 0.2ml/per day jambul fruit pulp extract through gavage and plain water for the next 5 days). Animals were euthanized on the 21st day to recover liver for histopathological and micrometric studies. The misalignment of the hepatic cord with narrowed and chocked sinusoidal spaces and some lesions in hepatic tissue were seen as persistent histopathological signs of lead exposure. Micrometric observations indicate that the mean cross-sectional area of the hepatocytes in the Pb group (483.5µ2) increased significantly than the control group (420.1µ2), similarly, the mean cross-sectional area of the hepatocytes nuclei in the Pb group was also significantly higher (76.69µ2) than the control (62.37µ2). These pathological and micrometric signs were convincingly reversed in Pb+Jm, additionally, hepatoblasts progenitor cells were frequently observed, indicating the rehabilitative and regenerative potential of jambul fruit pulp extract. Results indicate that jambul fruit pulp extract possesses precious hepato-protective and regenerative potentials against lead exposure-related hepato-histopathology. The findings of the present study indicate the nutraceutical role of jambul fruit pulp extract for potential human consumption.