Review - bioactive glass implants for potential application in structural bone repair

Q1 Materials Science Biomedical Glasses Pub Date : 2017-09-26 DOI:10.1515/bglass-2017-0005
M. Rahaman, W. Xiao, Wen-hai Huang
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引用次数: 20

Abstract

Abstract Bioactive glass particles andweak scaffolds have been used to heal small contained bone defects but an unmet challenge is the development of bioactive glass implants with the requisite mechanical reliability and in vivo performance to heal structural bone defects. Inadequate mechanical strength and a brittle mechanical response have been key concerns in the use of bioactive glass scaffolds in structural bone repair. Recent research has shown the capacity to create strong porous bioactive glass scaffolds and the ability of these scaffolds to heal segmental bone defects in small and large rodents at a rate comparable to autogenous bone grafts. Loading these strong porous scaffolds with bone morphogenetic protein-2 can significantly enhance their ability to regenerate bone. Recentwork has also shown that coating the external surface of strong porous scaffolds with an adherent biodegradable polymer can dramatically improve their load-bearing capacity in flexural loading and their work of fracture (a measure of toughness). These tough and strong bioactive glass-polymer composites with an internal architecture conducive to bone infiltration could provide optimal synthetic implants for structural bone repair.
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综述-生物活性玻璃植入物在骨结构修复中的潜在应用
摘要生物活性玻璃颗粒和弱支架已被用于治疗小型骨缺损,但尚未解决的挑战是开发具有必要机械可靠性和体内性能的生物活性玻璃植入物来治疗结构性骨缺损。在结构骨修复中使用生物活性玻璃支架时,机械强度不足和脆性机械反应一直是关键问题。最近的研究表明,有能力制造出坚固的多孔生物活性玻璃支架,并且这些支架能够以与自体骨移植物相当的速度治愈小型和大型啮齿动物的节段性骨缺损。用骨形态发生蛋白-2装载这些坚固的多孔支架可以显著增强它们的骨再生能力。最近的研究还表明,用粘附的可生物降解聚合物涂覆坚固多孔支架的外表面可以显著提高其在弯曲载荷下的承载能力和断裂功(韧性的衡量标准)。这些坚韧而坚固的生物活性玻璃聚合物复合材料具有有利于骨渗透的内部结构,可以为结构骨修复提供最佳的合成植入物。
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来源期刊
Biomedical Glasses
Biomedical Glasses Materials Science-Surfaces, Coatings and Films
自引率
0.00%
发文量
0
审稿时长
17 weeks
期刊介绍: Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.
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