Pub Date : 2020-01-01DOI: 10.1515/bglass-2020-0006
A. Fathi, F. Kermani, A. Behnamghader, S. Banijamali, M. Mozafari, F. Baino, S. Kargozar
Abstract Over the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3. The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.
{"title":"Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering","authors":"A. Fathi, F. Kermani, A. Behnamghader, S. Banijamali, M. Mozafari, F. Baino, S. Kargozar","doi":"10.1515/bglass-2020-0006","DOIUrl":"https://doi.org/10.1515/bglass-2020-0006","url":null,"abstract":"Abstract Over the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3. The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"6 1","pages":"57 - 69"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2020-0006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42328303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.1515/bglass-2020-0003
D. Tulyaganov, A. Akbarov, N. Ziyadullaeva, Bekhzod Khabilov, F. Baino
Abstract In this study, injectable pastes based on a clinically-tested bioactive glass and glycerol (used as organic carrier) were produced and characterized for further application in regenerative medicine. The paste preparation route, apatite-forming ability in simulated body fluid (SBF) solution, viscoelastic behavior and structural features revealed by means of scanning electron microscopy (SEM), FTIR and Raman spectroscopy were presented and discussed, also on the basis of the major experimental data obtained in previous studies. A mechanism illustrating the chemical interaction between bioactive glass and glycerol was proposed to support the bioactivity mechanism of injectable pastes. Then, the results of In vivo tests, conducted through injecting moldable paste into osseous defects made in rabbit’s femur, were reported. Animal studies revealed good osteoconductivity and bone bonding that occurred initially at the interface between the glass and the host bone, and further supported the suitability of these bioactive glass pastes in bone regenerative medicine.
{"title":"Injectable bioactive glass-based pastes for potential use in bone tissue repair","authors":"D. Tulyaganov, A. Akbarov, N. Ziyadullaeva, Bekhzod Khabilov, F. Baino","doi":"10.1515/bglass-2020-0003","DOIUrl":"https://doi.org/10.1515/bglass-2020-0003","url":null,"abstract":"Abstract In this study, injectable pastes based on a clinically-tested bioactive glass and glycerol (used as organic carrier) were produced and characterized for further application in regenerative medicine. The paste preparation route, apatite-forming ability in simulated body fluid (SBF) solution, viscoelastic behavior and structural features revealed by means of scanning electron microscopy (SEM), FTIR and Raman spectroscopy were presented and discussed, also on the basis of the major experimental data obtained in previous studies. A mechanism illustrating the chemical interaction between bioactive glass and glycerol was proposed to support the bioactivity mechanism of injectable pastes. Then, the results of In vivo tests, conducted through injecting moldable paste into osseous defects made in rabbit’s femur, were reported. Animal studies revealed good osteoconductivity and bone bonding that occurred initially at the interface between the glass and the host bone, and further supported the suitability of these bioactive glass pastes in bone regenerative medicine.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"6 1","pages":"23 - 33"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2020-0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47548795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.1515/bglass-2020-0007
M. Sujon, S. Noor, M. A. Zabidi, K. Shariff, M. Alam
Abstract Citation analysis of a certain publication acknowledges its impact on the scientific community. This study conducted a multivariate analysis of the top 50 most cited articles published on the field of Bioactive Glass. A systemic search was performed using the “All database” section of the Web of Science to retrieve the top 50 most cited original publications. The selected articles were then manually cross-matched with Elsevier Scopus and Google Scholar Database. Parameters such as article title, authorship, institution, country of publication, year, citation count, citation density, current citation index, and journal name were retrieved from Web of Science. Different ranges of citation numbers were retrieved for these publications in which 197-913 are from Web of Science, 209-962 are from Elsevier Scopus, and 269-1225 are from Google Scholar. A total of 153 authors contributed to this marked list, where Professor L.L. Hench contributed the highest number of articles (n=21). Imperial College London published the highest number of articles (n=21). In summary, this study provides a good scientometric picture of bioactive glass related publications, which illustrate the trend of biomaterials development over the years and suggests future scopes to the scientific community.
摘要对某一出版物的引文分析承认其对科学界的影响。这项研究对生物活性玻璃领域发表的50篇最受引用的文章进行了多元分析。使用科学网的“所有数据库”部分进行了系统搜索，以检索被引用最多的50篇原创出版物。然后将所选文章与爱思唯尔Scopus和谷歌学者数据库进行手动交叉匹配。从Web of Science中检索到文章标题、作者、机构、发表国家、年份、引用次数、引用密度、当前引用指数和期刊名称等参数。这些出版物检索到了不同范围的引文编号，其中197-913来自Web of Science，209-962来自Elsevier Scopus，269-1225来自Google Scholar。共有153位作者对这份有标记的名单做出了贡献，其中L.L.Hench教授的文章数量最多（n=21）。伦敦帝国理工学院发表的文章数量最多（n=21）。总之，这项研究为生物活性玻璃相关出版物提供了一幅很好的科学计量图，说明了多年来生物材料的发展趋势，并为科学界提出了未来的发展方向。
{"title":"Bibliometric profiles of top 50 most cited articles on bioactive glass","authors":"M. Sujon, S. Noor, M. A. Zabidi, K. Shariff, M. Alam","doi":"10.1515/bglass-2020-0007","DOIUrl":"https://doi.org/10.1515/bglass-2020-0007","url":null,"abstract":"Abstract Citation analysis of a certain publication acknowledges its impact on the scientific community. This study conducted a multivariate analysis of the top 50 most cited articles published on the field of Bioactive Glass. A systemic search was performed using the “All database” section of the Web of Science to retrieve the top 50 most cited original publications. The selected articles were then manually cross-matched with Elsevier Scopus and Google Scholar Database. Parameters such as article title, authorship, institution, country of publication, year, citation count, citation density, current citation index, and journal name were retrieved from Web of Science. Different ranges of citation numbers were retrieved for these publications in which 197-913 are from Web of Science, 209-962 are from Elsevier Scopus, and 269-1225 are from Google Scholar. A total of 153 authors contributed to this marked list, where Professor L.L. Hench contributed the highest number of articles (n=21). Imperial College London published the highest number of articles (n=21). In summary, this study provides a good scientometric picture of bioactive glass related publications, which illustrate the trend of biomaterials development over the years and suggests future scopes to the scientific community.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"6 1","pages":"70 - 84"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2020-0007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49078806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.1515/bglass-2020-0001
P. R. D. Cerro, Henri Teittinen, I. Norrbo, M. Lastusaari, J. Massera, L. Petit
Abstract Persistent luminescent amorphous borosilicate scaffolds were successfully prepared, for the first time, with a porosity of >70% using the burn-off technique. The persistent luminescence was obtained by adding the SrAl2O4:Eu2+,Dy3+ microparticles: i) in the glass melt or ii) in the glass crushed into powder prior to the sintering. The scaffolds prepared by adding the microparticles in the glass melt exhibits lower persistent luminescence and a slower reaction rate in simulated body fluid than the scaffolds prepared by adding the microparticles in the glass powder due to the release of strontium from the microparticles into the glass during the glass melting.
{"title":"Novel borosilicate bioactive scaffolds with persistent luminescence","authors":"P. R. D. Cerro, Henri Teittinen, I. Norrbo, M. Lastusaari, J. Massera, L. Petit","doi":"10.1515/bglass-2020-0001","DOIUrl":"https://doi.org/10.1515/bglass-2020-0001","url":null,"abstract":"Abstract Persistent luminescent amorphous borosilicate scaffolds were successfully prepared, for the first time, with a porosity of >70% using the burn-off technique. The persistent luminescence was obtained by adding the SrAl2O4:Eu2+,Dy3+ microparticles: i) in the glass melt or ii) in the glass crushed into powder prior to the sintering. The scaffolds prepared by adding the microparticles in the glass melt exhibits lower persistent luminescence and a slower reaction rate in simulated body fluid than the scaffolds prepared by adding the microparticles in the glass powder due to the release of strontium from the microparticles into the glass during the glass melting.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"6 1","pages":"1 - 9"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2020-0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44434748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.1515/bglass-2020-0004
A. Arafat, Sabrin A. Samad, J. Titman, A. Lewis, E. Barney, I. Ahmed
Abstract This study investigates the role of yttrium in phosphate-based glasses in the system 45(P2O5)–25(CaO)– (30-x)(Na2O)–x(Y2O3) (0≤x≤5) prepared via melt quenching and focuses on their structural characterisation and degradation properties. The structural analyses were performed using a combination of solid-state nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). 31P NMR analysis showed that depolymerisation of the phosphate network occurred which increased with Y2O3 content as metaphosphate units (Q2) decreased with subsequent increase in pyrophosphate species (Q1). The NMR results correlated well with structural changes observed via FTIR and XPS analyses. XRD analysis of crystallised glass samples revealed the presence of calcium pyrophosphate (Ca2P2O7) and sodium metaphosphate (NaPO3) phases for all the glass formulations explored. Yttrium-containing phases were found for the formulations containing 3 and 5 mol% Y2O3. Degradation analyses performed in Phosphate buffer saline (PBS) and Milli-Q water revealed significantly reduced rates with addition of Y2O3 content. This decrease was attributed to the formation of Y-O-P bonds where the octahedral structure of yttrium (YO6) cross-linked phosphate chains, subsequently leading to an increase in chemical durability of the glasses. The ion release studies also showed good correlation with the degradation profiles.
{"title":"Yttrium doped phosphate-based glasses: structural and degradation analyses","authors":"A. Arafat, Sabrin A. Samad, J. Titman, A. Lewis, E. Barney, I. Ahmed","doi":"10.1515/bglass-2020-0004","DOIUrl":"https://doi.org/10.1515/bglass-2020-0004","url":null,"abstract":"Abstract This study investigates the role of yttrium in phosphate-based glasses in the system 45(P2O5)–25(CaO)– (30-x)(Na2O)–x(Y2O3) (0≤x≤5) prepared via melt quenching and focuses on their structural characterisation and degradation properties. The structural analyses were performed using a combination of solid-state nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). 31P NMR analysis showed that depolymerisation of the phosphate network occurred which increased with Y2O3 content as metaphosphate units (Q2) decreased with subsequent increase in pyrophosphate species (Q1). The NMR results correlated well with structural changes observed via FTIR and XPS analyses. XRD analysis of crystallised glass samples revealed the presence of calcium pyrophosphate (Ca2P2O7) and sodium metaphosphate (NaPO3) phases for all the glass formulations explored. Yttrium-containing phases were found for the formulations containing 3 and 5 mol% Y2O3. Degradation analyses performed in Phosphate buffer saline (PBS) and Milli-Q water revealed significantly reduced rates with addition of Y2O3 content. This decrease was attributed to the formation of Y-O-P bonds where the octahedral structure of yttrium (YO6) cross-linked phosphate chains, subsequently leading to an increase in chemical durability of the glasses. The ion release studies also showed good correlation with the degradation profiles.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"6 1","pages":"34 - 49"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2020-0004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45238827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.1515/bglass-2020-0005
F. Baino, E. Fiume
Abstract Porosity is known to play a pivotal role in dictating the functional properties of biomedical scaffolds, with special reference to mechanical performance. While compressive strength is relatively easy to be experimentally assessed even for brittle ceramic and glass foams, elastic properties are much more difficult to be reliably estimated. Therefore, describing and, hence, predicting the relationship between porosity and elastic properties based only on the constitutive parameters of the solid material is still a challenge. In this work, we quantitatively compare the predictive capability of a set of different models in describing, over a wide range of porosity, the elastic modulus (7 models), shear modulus (3 models) and Poisson’s ratio (7 models) of bioactive silicate glass-derived scaffolds produced by foam replication. For these types of biomedical materials, the porosity dependence of elastic and shear moduli follows a second-order power-law approximation, whereas the relationship between porosity and Poisson’s ratio is well fitted by a linear equation.
{"title":"Modelling the elastic mechanical properties of bioactive glass-derived scaffolds","authors":"F. Baino, E. Fiume","doi":"10.1515/bglass-2020-0005","DOIUrl":"https://doi.org/10.1515/bglass-2020-0005","url":null,"abstract":"Abstract Porosity is known to play a pivotal role in dictating the functional properties of biomedical scaffolds, with special reference to mechanical performance. While compressive strength is relatively easy to be experimentally assessed even for brittle ceramic and glass foams, elastic properties are much more difficult to be reliably estimated. Therefore, describing and, hence, predicting the relationship between porosity and elastic properties based only on the constitutive parameters of the solid material is still a challenge. In this work, we quantitatively compare the predictive capability of a set of different models in describing, over a wide range of porosity, the elastic modulus (7 models), shear modulus (3 models) and Poisson’s ratio (7 models) of bioactive silicate glass-derived scaffolds produced by foam replication. For these types of biomedical materials, the porosity dependence of elastic and shear moduli follows a second-order power-law approximation, whereas the relationship between porosity and Poisson’s ratio is well fitted by a linear equation.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"6 1","pages":"50 - 56"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2020-0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44904711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.1515/bglass-2020-0002
Zakaria Tabia, Sihame Akhtach, K. Mabrouk, Meriame Bricha, K. Nouneh, A. Ballamurugan
Abstract Multifunctionality can be achieved for bioactive glasses by endowing them with multiple other properties along with bioactivity. One way to address this topic is by doping these glasses with therapeutic metallic ions. In this work, we put under investigation a series of bioactive glasses doped with tantalum. We aim to study the effect of tantalum, on the structure, bioactivity and antibacterial property of a ternary bioactive glass composition based on SiO2-CaO-P2O5. Fourier Transformed Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD) and Electron Scanning Microscopy (SEM) were used to assess the structural and morphological properties of these glasses and monitor their changes after in vitro acellular bioactivity test. Antibacterial activity was tested against gram positive and negative bacteria. Characterization results confirmed the presence of calcium carbonate crystallites along with the amorphous silica matrix. The assessment of bioactivity in SBF indicated that all compositions showed a fast bioactive response after only six hours of immersion period. However, analytical characterization revealed that tantalum introduced a slight latency in hydroxyapatite deposition at higher concentrations (0.8-1 %mol). Antibacterial test showed that tantalum ions had an inhibition effect on the growth of E. coli and S. aureus. This effect was more pronounced in compositions where mol% of tantalum is superior to 0.4%. These results proved that tantalum could be used, in intermediate proportions, as a promising multifunctional dopant element in bioactive glasses for bone regeneration applications.
{"title":"Tantalum doped SiO2-CaO-P2O5 based bioactive glasses: Investigation of in vitro bioactivity and antibacterial activities","authors":"Zakaria Tabia, Sihame Akhtach, K. Mabrouk, Meriame Bricha, K. Nouneh, A. Ballamurugan","doi":"10.1515/bglass-2020-0002","DOIUrl":"https://doi.org/10.1515/bglass-2020-0002","url":null,"abstract":"Abstract Multifunctionality can be achieved for bioactive glasses by endowing them with multiple other properties along with bioactivity. One way to address this topic is by doping these glasses with therapeutic metallic ions. In this work, we put under investigation a series of bioactive glasses doped with tantalum. We aim to study the effect of tantalum, on the structure, bioactivity and antibacterial property of a ternary bioactive glass composition based on SiO2-CaO-P2O5. Fourier Transformed Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD) and Electron Scanning Microscopy (SEM) were used to assess the structural and morphological properties of these glasses and monitor their changes after in vitro acellular bioactivity test. Antibacterial activity was tested against gram positive and negative bacteria. Characterization results confirmed the presence of calcium carbonate crystallites along with the amorphous silica matrix. The assessment of bioactivity in SBF indicated that all compositions showed a fast bioactive response after only six hours of immersion period. However, analytical characterization revealed that tantalum introduced a slight latency in hydroxyapatite deposition at higher concentrations (0.8-1 %mol). Antibacterial test showed that tantalum ions had an inhibition effect on the growth of E. coli and S. aureus. This effect was more pronounced in compositions where mol% of tantalum is superior to 0.4%. These results proved that tantalum could be used, in intermediate proportions, as a promising multifunctional dopant element in bioactive glasses for bone regeneration applications.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"6 1","pages":"10 - 22"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2020-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45183983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.1515/bglass-2019-0002
S. Mokhtari, A. Wren
Abstract The physical, mechanical, and biological behaviour of copper containing glass polyalkenotare cements were investigated, where copper (Cu2+) was incorporated into a SiO2-ZnO-CaO-SrO-P2O5 based glass system. Three GPCs were formulated for this study, a Control and two Cu-GPCs with 6 (Cu-1) and 12 (Cu-2) Mol.% of CuO substituted for the SiO2 in the glass. Rheological evaluation of GPCs determined that the addition of the Cu decreases the working and setting times in the cements. The mechanical properties of the cements were evaluated after 1 - 21 days incubation in DI water. The compressive strength of the cements were found to range between 21-36 MPa, with Cu-1 having the highest compressive strength. Biaxial flexural strength and Shear Bond Strength of the GPCs were found to increase with respect to time and were higher for the Cu-GPCs at 14 MPa and 2.1 MPa respectively. Bioactivity testing was conducted using Simulated Body Fluid (SBF) which revealed CaP precipitants on each of the GPCs surfaces. The effect o f Cu addition to the GPCs greatly enhanced the antibacterial inhibition zone (IZ) when tested in E.coli (3mm), S.aureus (24mm) and S.epidermidis (22mm). Cytocompatibility testing revealed more favorable MC3T3 osteoblast cell viability when compared to the Control GPC.
{"title":"Investigating the effect of Copper Addition on SiO2-ZnO-CaO-SrO-P2O5 Glass Polyalkenoate Cements: Physical, Mechanical and Biological Behavior","authors":"S. Mokhtari, A. Wren","doi":"10.1515/bglass-2019-0002","DOIUrl":"https://doi.org/10.1515/bglass-2019-0002","url":null,"abstract":"Abstract The physical, mechanical, and biological behaviour of copper containing glass polyalkenotare cements were investigated, where copper (Cu2+) was incorporated into a SiO2-ZnO-CaO-SrO-P2O5 based glass system. Three GPCs were formulated for this study, a Control and two Cu-GPCs with 6 (Cu-1) and 12 (Cu-2) Mol.% of CuO substituted for the SiO2 in the glass. Rheological evaluation of GPCs determined that the addition of the Cu decreases the working and setting times in the cements. The mechanical properties of the cements were evaluated after 1 - 21 days incubation in DI water. The compressive strength of the cements were found to range between 21-36 MPa, with Cu-1 having the highest compressive strength. Biaxial flexural strength and Shear Bond Strength of the GPCs were found to increase with respect to time and were higher for the Cu-GPCs at 14 MPa and 2.1 MPa respectively. Bioactivity testing was conducted using Simulated Body Fluid (SBF) which revealed CaP precipitants on each of the GPCs surfaces. The effect o f Cu addition to the GPCs greatly enhanced the antibacterial inhibition zone (IZ) when tested in E.coli (3mm), S.aureus (24mm) and S.epidermidis (22mm). Cytocompatibility testing revealed more favorable MC3T3 osteoblast cell viability when compared to the Control GPC.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"5 1","pages":"13 - 33"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2019-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48077552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.1515/bglass-2019-0001
R. Wetzel, L. Hupa, D. Brauer
Abstract Glass ionomer cements (GIC) are used in restorative dentistry and their properties (low heat during setting, adhesion to mineralised tissue and surgical metals) make them of great interest for bone applications.However, dental GIC are based on aluminium-containing glasses, and the resulting release of aluminium ions from the cements needs to be avoided for applications as bone cements. Replacing aluminium ions in glasses for use in glass ionomer cements is challenging, as aluminium ions play a critical role in the required glass degradation by acid attack as well as in GIC mechanical stability. Magnesium ions have been used as an alternative for aluminium in the glass component, but so far no systematic study has looked into the actual role of magnesium ions. The aim of the present study is therefore the systematic comparison of the effect of magnesium ions compared to calcium ions in GIC glasses. It is shown that by partially substituting MgO for CaO in simple SiO2-CaO-CaF2 glasses, ion release from the glass and, subsequently, GIC setting behaviour can be adjusted. Magnesium ions act as typical network modifiers here but owing to their larger field strength compared to calcium ions reduce ion release from the glasses significantly. By choosing an optimum ratio of magnesium and calcium ions in the glass, GIC setting and subsequently compressive strength can be controlled.
{"title":"Glass ionomer bone cements based on magnesium-containing bioactive glasses","authors":"R. Wetzel, L. Hupa, D. Brauer","doi":"10.1515/bglass-2019-0001","DOIUrl":"https://doi.org/10.1515/bglass-2019-0001","url":null,"abstract":"Abstract Glass ionomer cements (GIC) are used in restorative dentistry and their properties (low heat during setting, adhesion to mineralised tissue and surgical metals) make them of great interest for bone applications.However, dental GIC are based on aluminium-containing glasses, and the resulting release of aluminium ions from the cements needs to be avoided for applications as bone cements. Replacing aluminium ions in glasses for use in glass ionomer cements is challenging, as aluminium ions play a critical role in the required glass degradation by acid attack as well as in GIC mechanical stability. Magnesium ions have been used as an alternative for aluminium in the glass component, but so far no systematic study has looked into the actual role of magnesium ions. The aim of the present study is therefore the systematic comparison of the effect of magnesium ions compared to calcium ions in GIC glasses. It is shown that by partially substituting MgO for CaO in simple SiO2-CaO-CaF2 glasses, ion release from the glass and, subsequently, GIC setting behaviour can be adjusted. Magnesium ions act as typical network modifiers here but owing to their larger field strength compared to calcium ions reduce ion release from the glasses significantly. By choosing an optimum ratio of magnesium and calcium ions in the glass, GIC setting and subsequently compressive strength can be controlled.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"5 1","pages":"1 - 12"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2019-0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45899372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.1515/bglass-2019-0003
Ulrike Brokmann, T. Milde, E. Rädlein, K. Liefeith
Abstract The biocompatibility of photosensitive glasses allows various biomedical applications; one is the field of tissue engineering and more precisely microengineered tissue-on-a-chip platforms to study the tissue microenvironment and disease modelling. Three dimensional architectures of adapted components are required for modern materials. A photosensitive lithiumalumosilicate glass FS21 was investigated regarding the interaction with a Ti:Sapphire laser systemto build three dimensional buried channels inside the glass. Femtosecond laser radiation with a wavelength of 800 nm and pulse duration of 140 fs was used to modify the glass structure. Subsurface channel geometries were achieved by a subsequent thermal treatment and were formed into capillaries using wet chemical etching of the exposed and crystallised channels. Contrary to ultraviolet (UV) exposure, spectral optical investigations showed that fs laser exposure caused various radiation induced defects in the base glass coupled with the generation of photoelectrons for the photochemical modification of silver ions. We observed an outgassing of different species coming from raw materials of the original glass batch during the glass crystallisation process. Etch rate ratios differ between 1:25 and 1:45 and are dependent on: stoichiometric deviation between surface and bulk, crystal size and distribution and exchange of the etching agent in narrow capillaries.
{"title":"Fabrication of 3D microchannels for tissue engineering in photosensitive glass using NIR femtosecond laser radiation","authors":"Ulrike Brokmann, T. Milde, E. Rädlein, K. Liefeith","doi":"10.1515/bglass-2019-0003","DOIUrl":"https://doi.org/10.1515/bglass-2019-0003","url":null,"abstract":"Abstract The biocompatibility of photosensitive glasses allows various biomedical applications; one is the field of tissue engineering and more precisely microengineered tissue-on-a-chip platforms to study the tissue microenvironment and disease modelling. Three dimensional architectures of adapted components are required for modern materials. A photosensitive lithiumalumosilicate glass FS21 was investigated regarding the interaction with a Ti:Sapphire laser systemto build three dimensional buried channels inside the glass. Femtosecond laser radiation with a wavelength of 800 nm and pulse duration of 140 fs was used to modify the glass structure. Subsurface channel geometries were achieved by a subsequent thermal treatment and were formed into capillaries using wet chemical etching of the exposed and crystallised channels. Contrary to ultraviolet (UV) exposure, spectral optical investigations showed that fs laser exposure caused various radiation induced defects in the base glass coupled with the generation of photoelectrons for the photochemical modification of silver ions. We observed an outgassing of different species coming from raw materials of the original glass batch during the glass crystallisation process. Etch rate ratios differ between 1:25 and 1:45 and are dependent on: stoichiometric deviation between surface and bulk, crystal size and distribution and exchange of the etching agent in narrow capillaries.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"5 1","pages":"34 - 45"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2019-0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46167053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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