OPPORTUNITY TO INNOVATE FOR INFANTS

Q4 Pharmacology, Toxicology and Pharmaceutics INDIAN DRUGS Pub Date : 2023-08-28 DOI:10.53879/id.60.08.p0005
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Abstract

Dear Reader, Lactose intolerance is well-known for decades. Difficulty to metabolize lactose due to a genetic disorder, though exists in a large population, has not been taken too seriously. Reason being, it’s not a fatal disorder and the intolerance leads to some amount of bloating, indigestion, maybe a bit of acidity, and distaste to drink milk. However, as science and technology progressed, one of the numerous causes for fatalities of newly born infants and children have come to the forefront. Though rare, genetic (inherited) disorders in which the body cannot turn food into energy and metabolize, have been detected. These are referred as inborn errors of metabolism (IEM). Such disorders are usually caused by defects in specific proteins (enzymes) that help breakdown (metabolize) parts of food. Examples include organic acidurias, fatty acid oxidation defect, urea cycle disorder, mitochondrial disease, galactosemia, maple sugar urine disease (maple sugar disorder), fructose intolerance, phenyl ketone urea amongst others
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为婴儿提供创新机会
亲爱的读者,乳糖不耐症已经有几十年的历史了。由于遗传疾病导致的乳糖代谢困难,虽然存在于大量人群中,但并没有受到太大的重视。原因是,这不是一种致命的疾病,不耐受会导致一定程度的腹胀、消化不良,可能还有一点酸性,以及讨厌喝牛奶。然而,随着科学技术的进步,新生儿和儿童死亡的众多原因之一已经浮出水面。虽然罕见,但身体不能将食物转化为能量并进行代谢的遗传性疾病已经被发现。这些被称为先天性代谢错误(IEM)。这种疾病通常是由帮助分解(代谢)部分食物的特定蛋白质(酶)缺陷引起的。例子包括有机酸尿症、脂肪酸氧化缺陷、尿素循环紊乱、线粒体疾病、半乳糖血症、枫糖尿病(枫糖紊乱)、果糖不耐受、苯酮脲等
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来源期刊
INDIAN DRUGS
INDIAN DRUGS Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
0.30
自引率
0.00%
发文量
98
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