Effects of atomizing inhalation of alprostadil on pulmonary oxygenation function after one lung ventilation

国际麻醉学与复苏杂志 Pub Date : 2019-12-15 DOI:10.3760/CMA.J.ISSN.1673-4378.2019.12.004

Q. Gao, Yongtao Gao, Zhi Yin, Zhen-zhen Yuan

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Abstract

Objective To observe the effects of atomizing inhalation of alprostadil on pulmonary oxygenation function after one lung ventilation (OLV). Methods Forty-two patients with thoracic esophageal cancer undergoing elective resection were enrolled in the study and divided into two groups (n=21): a test group (group T) and a control group (group C) according to the random number table. When OLV started, group T received atomizing inhalation of alprostadil 0.2 μg/kg via the left lung, while group C received the same amount of normal saline. Radial arterial blood samples were taken 3 min before OLV (T1), 3 min after OLV (T2), and 30 min after T2(T3) for blood gas analysis and oxygenation index (OI) and pulmonary shunt rate (Qs/Qt) were calculated. The hemodynamic indexes of the two groups were recorded at these points. Results Patients in both groups presented remarkable decreases in OI values and marked increases in Qs/Qt at T2 and T3 compared with those at T1(P 0.05). Conclusions Atomizing inhalation of alprostadil during OLV towards ventilated lungs can improve oxygenation function and decrease intrapulmonary shunt in patients after OLV. Key words: One lung ventilation; Alprostadil; Oxygenation function

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雾化吸入前列地尔对单肺通气后肺氧合功能的影响

目的观察前列地尔雾化吸入对单肺通气（OLV）后肺氧合功能的影响。方法选择癌症择期切除患者42例，按随机数表分为试验组（T组）和对照组（C组）2组（n=21）。OLV开始时，T组通过左肺雾化吸入前列地尔0.2μg/kg，而C组则接受等量的生理盐水。在OLV前3分钟（T1）、OLV后3分钟（T2）和T2后30分钟（T3）采集桡动脉血样进行血气分析，并计算氧合指数（OI）和肺分流率（Qs/Qt）。记录两组患者的血液动力学指标。结果两组患者在T2和T3时OI值均显著下降，Qs/Qt均显著升高（P＜0.05）。关键词：单肺通气；前列地尔；充氧功能

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国际麻醉学与复苏杂志

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