Exaggerated risk perception of asbestos-related diseases: commentary

Q4 Biochemistry, Genetics and Molecular Biology Sibirskii nauchnyi meditsinskii zhurnal Pub Date : 2023-04-27 DOI:10.18699/ssmj20230201
S. Jargin
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Abstract

Health risks from asbestos have been evaluated on the basis of professional histories from remote past, when exposures at workplaces were greater than today. The linear no-threshold model has been applied, although its relevance has not been demonstrated. Fibers are often found in the lungs and pleura at post mortem examinations. The fnding of fbers does not prove that a disease was caused by asbestos. It can be reasonably assumed that targeted search for mesothelioma and other asbestos-related diseases in exposed people resulted in increased detection rate. Histological and immunochemical characteristics of malignant mesothelioma partly overlap with other cancers, which may contribute to overdiagnosis in exposed populations. Amphibole asbestos is more toxic than chrysotile but there are discrepancies between experimental and epidemiological data. The promising way to obtain reliable information is lifelong animal experiments. Asbestos bans applied in some countries are excessive and should be reconsidered on the basis of independent research. It can be reasonably assumed that non-use of asbestos-containing brakes, freproofng, and insulation increases the harm from fres, armed conflicts and trafc accidents.
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夸大石棉相关疾病的风险认知:评论
石棉的健康风险是根据遥远过去的职业史进行评估的,当时工作场所的石棉暴露量比今天更大。线性无阈值模型已被应用,尽管其相关性尚未得到证明。尸检时,肺和胸膜中经常发现纤维。fbers的鉴定并不能证明一种疾病是由石棉引起的。可以合理地假设,在暴露人群中有针对性地搜索间皮瘤和其他石棉相关疾病会提高检测率。恶性间皮瘤的组织学和免疫化学特征与其他癌症部分重叠,这可能导致暴露人群的过度诊断。两栖类石棉比温石棉毒性更大,但实验数据和流行病学数据之间存在差异。获得可靠信息的有希望的方法是终身动物实验。一些国家实施的石棉禁令过多,应在独立研究的基础上重新考虑。可以合理地假设,不使用含石棉的制动器、防火和隔热材料会增加fres、武装冲突和交通事故的危害。
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来源期刊
CiteScore
0.40
自引率
0.00%
发文量
54
审稿时长
12 weeks
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