Correlation of serum vitamin D with serum lipid in middle-aged and elderly people

Abstract

Objective To investigate the correlation of serum 25-hydroxy-vitamin D (25-OH-D) with lipid profiles in middle-aged and elderly patients. Methods A total of 284 patients aged over 40 years and admitted in our hospital from May 2016 to May 2017 were selected and divided into four groups according to 25-OH-D levels as the group of normal level which was not less than 30 ng/ml, the group of slight deficiency which was between 20 and 29 ng/ml, the group of moderate deficiency which was between 10 and 19 ng/ml, and the group of severely deficiency which was under 10 ng/ml. Fasting blood draw were taken to detect liver and renal functions, lipids, calcium, phosphorus and 25-OH-D levels. The level of lipids between groups was compared by one-way ANOVA, and the association between lipid profiles and 25-OH-D levels was assessed by Pearson correlation and multiple linear regression. Results The levels of triglyceride (TG), low density lipoprotein cholesterin (LDL-C) and total cholesterol/high density lipoprotein cholesterol (TC/ HDL-C) were significantly higher and the HDL-C levels were significantly lower in the groups of severely deficiency, moderate deficiency and slight deficiency than in the normal group (P=0.035, P=0.015, P=0.013). The levels of serum 25-OH-D were significantly higher in HDL-C≥1.04 mmol/L group than in HDL-C<1.04 mmol/L group (Female P=0.007, male P=0.034). The correlation analysis showed that serum 25-OH-D level was positively associated with HDL-C (female r=0.309, P=0.002, male r=0.241, P=0.002). The multiple linear regression analysis showed that 25-OH-D level was positively correlated with HDL-C, after adjusting age, BMI, liver and kidney function, serum calcium and serum phosphorus (female β=0.259, P=0.047, male β=0.217, P=0.049). Conclusion The incidence of vitamin D deficiency is high in middle-aged and elderly patients, and the level of serum 25-OH-D is positively correlated with HDL-C. Key words: 25-hydroxy vitamin D; Lipid profiles; Middle-aged and elderly people