Pub Date : 2019-12-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.06.003
Shixuan Liu, Yong Xue, T. Yuan, Yong Fu, Naishi Li, Ying-yue Dong, B. Zhu
Objective To explore the difference of gut microbiota between type 2 diabetes mellitus (T2DM) and non-diabetic population in Beijing. Methods 83 T2DM patients were selected as T2DM group and 64 non-diabetic subjects were selected as control group. Fecal samples were collected from all the subjects. The intestinal flora was detected by metagenome sequencing technology. Results 11 bacterialphyla were detected in the two groups, there were significant differences in species diversity of Actinobacteria(P=0.013), Firmicutes(P=0.005), Fusobacteria(P=0.001), Proteobacteria(P<0.001) between the two groups.Actinobacteria, Fusobacteria and Proteobacteria were all enriched in the T2DM group, Firmicutes were enriched in the control group. 152 bacterial genera were detected in the two groups with 31 bacterial genera ofsignificant differences. In T2DM group, the levels of Roseburia, Eubacterium and Faecalibacterium decreased, while the levels of Bifidobacterium, Lactobacillus and Escherichia increased. Conclusion There are significant differ-ences in the composition of gut microbiota between T2DM patients and non-diabetic population. Regulation of gut microbiota in T2DM patients may be helpful to improve the condition of T2DM. Key words: Type 2 diabetes; Gut microbiota; Metagenome analysis
{"title":"Differences of gut microbiota between type 2 diabetes and non-diabetic population","authors":"Shixuan Liu, Yong Xue, T. Yuan, Yong Fu, Naishi Li, Ying-yue Dong, B. Zhu","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.06.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.06.003","url":null,"abstract":"Objective \u0000To explore the difference of gut microbiota between type 2 diabetes mellitus (T2DM) and non-diabetic population in Beijing. \u0000 \u0000 \u0000Methods \u000083 T2DM patients were selected as T2DM group and 64 non-diabetic subjects were selected as control group. Fecal samples were collected from all the subjects. The intestinal flora was detected by metagenome sequencing technology. \u0000 \u0000 \u0000Results \u000011 bacterialphyla were detected in the two groups, there were significant differences in species diversity of Actinobacteria(P=0.013), Firmicutes(P=0.005), Fusobacteria(P=0.001), Proteobacteria(P<0.001) between the two groups.Actinobacteria, Fusobacteria and Proteobacteria were all enriched in the T2DM group, Firmicutes were enriched in the control group. 152 bacterial genera were detected in the two groups with 31 bacterial genera ofsignificant differences. In T2DM group, the levels of Roseburia, Eubacterium and Faecalibacterium decreased, while the levels of Bifidobacterium, Lactobacillus and Escherichia increased. \u0000 \u0000 \u0000Conclusion \u0000There are significant differ-ences in the composition of gut microbiota between T2DM patients and non-diabetic population. Regulation of gut microbiota in T2DM patients may be helpful to improve the condition of T2DM. \u0000 \u0000 \u0000Key words: \u0000Type 2 diabetes; Gut microbiota; Metagenome analysis","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"342-348"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46656398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.06.006
Yiping Li, Haofen Xie, Zejun Cai
Objective To explore the clinical effect of applying standard process management in early enteral nutrition support for elderly patients with gastric cancer after operation. Methods A total of 142 elderly patients with gastric cancer in our hospital were randomly divided into control group(n=71) treated with the traditional nursing of enteral nutrition and intervention group(n=71) adopting the standardized process management, and then enteral nutrition tolerance, complications, nutritional status and recovery of gastrointestinal function were compared between the two groups. Results There was no significant difference in age, sex and preoperative nutritional condition and operation situation between the two groups(P>0.05). The incidence of nutritional intolerance and the cost of nutritional support were lower than those in the control group(P 0.05) . Conclusions Standardized process management of early enteral nutrition after operation could significantly improve the tolerance of enteral nutrition, meanwhile, it has positive significance in promoting rapid recovery of elderly patients with gastric cancer. Key words: Standardization; Enteral nutrition; Elderly; Gastric cancer
{"title":"Effect of standardized process management of early enteral nutrition after operation on rapid recovery of elderly patients with gastric cancer","authors":"Yiping Li, Haofen Xie, Zejun Cai","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.06.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.06.006","url":null,"abstract":"Objective \u0000To explore the clinical effect of applying standard process management in early enteral nutrition support for elderly patients with gastric cancer after operation. \u0000 \u0000 \u0000Methods \u0000A total of 142 elderly patients with gastric cancer in our hospital were randomly divided into control group(n=71) treated with the traditional nursing of enteral nutrition and intervention group(n=71) adopting the standardized process management, and then enteral nutrition tolerance, complications, nutritional status and recovery of gastrointestinal function were compared between the two groups. \u0000 \u0000 \u0000Results \u0000There was no significant difference in age, sex and preoperative nutritional condition and operation situation between the two groups(P>0.05). The incidence of nutritional intolerance and the cost of nutritional support were lower than those in the control group(P 0.05) . \u0000 \u0000 \u0000Conclusions \u0000Standardized process management of early enteral nutrition after operation could significantly improve the tolerance of enteral nutrition, meanwhile, it has positive significance in promoting rapid recovery of elderly patients with gastric cancer. \u0000 \u0000 \u0000Key words: \u0000Standardization; Enteral nutrition; Elderly; Gastric cancer","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"361-366"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49618448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.06.010
Dengdeng Pan, Cheng-ying Kong, T. Shen
In recent years, with the in-depth research on intestinal microecology, probiotics, probiotics, synbiotics, fecal bacteria transplantation and other microecological therapies have become new clinical treatment and intervention methods.The occurrence and development of some chronic diseases are closely related to the disorder of intestinal flora.Therefore, in clinical practice, the treatment and adjuvant treatment of chronic diseases related to intestinal flora disorder with the method of intestinal microecology will bring better treatment options and clinical prognosis.How to better regulate intestinal flora to bring more benefits to such patients, as well as what kind of microecologics and treatment methods are the primary problems and challenges in the intervention of chronic diseases with microecologics.Based on the current trend of intestinal microecological intervention in chronic diseases, this article proposedthe microecological intervention strategy, in order to improve theunderstanding of this topic. Key words: Intestinal microecology; Chronicdisease; Microecological preparation; Intervention strategy
{"title":"Trends and strategies of intestinal microecological intervention for chronic diseases","authors":"Dengdeng Pan, Cheng-ying Kong, T. Shen","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.06.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.06.010","url":null,"abstract":"In recent years, with the in-depth research on intestinal microecology, probiotics, probiotics, synbiotics, fecal bacteria transplantation and other microecological therapies have become new clinical treatment and intervention methods.The occurrence and development of some chronic diseases are closely related to the disorder of intestinal flora.Therefore, in clinical practice, the treatment and adjuvant treatment of chronic diseases related to intestinal flora disorder with the method of intestinal microecology will bring better treatment options and clinical prognosis.How to better regulate intestinal flora to bring more benefits to such patients, as well as what kind of microecologics and treatment methods are the primary problems and challenges in the intervention of chronic diseases with microecologics.Based on the current trend of intestinal microecological intervention in chronic diseases, this article proposedthe microecological intervention strategy, in order to improve theunderstanding of this topic. \u0000 \u0000 \u0000Key words: \u0000Intestinal microecology; Chronicdisease; Microecological preparation; Intervention strategy","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"385-388"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41492681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.06.002
Zhida Chen, Yunhe Gao, H. Xi, Tang Yun
Objective To analyze the occurrence and clinical significance of hypophosphatemia after moderate-to-major abdominal surgery. Methods A total of 120 patients who had received moderate to major abdominal surgery and then transferred to the intensive care unit (ICU) from January 2008 to October 2018 were retrospectively analyzed. The peri-operative parameters of serum inorganic phosphate and calcium levels were recorded and analyzed. The incidence of hypophosphatemia after the operation was calculated. The effect of phosphorus-supplement infusion on the complications and mortality within 30 days after the operation were observed. Results After moderate-to-major surgery, the phosphorus concentration significantly decreased [(1.21±0.27) vs. (0.83±0.24)mmol/L, P<0.05]; the incidence of hypophosphatemia was 58.3%, especially in patients with nutritional risk assessed before the operation. The post-operative complications were less in the phosphorus-supplement infusion group than in the control group (17.5% vs. 41.3%, P=0.028). Conclusion The incidence of hypophosphatemia is relatively high after moderate-to-major abdominal surgery, especially in patients with nutritional risks. The treatment of phosphorus-supplement infusion can benefit the patients in their short-term prognosis. Key words: Hypophosphatemia; Critically ill; Nutritional risk
{"title":"Clinical significance of peri-operative change of serum inorganic phosphate levels after moderate-to-major abdominal surgery","authors":"Zhida Chen, Yunhe Gao, H. Xi, Tang Yun","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.06.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.06.002","url":null,"abstract":"Objective \u0000To analyze the occurrence and clinical significance of hypophosphatemia after moderate-to-major abdominal surgery. \u0000 \u0000 \u0000Methods \u0000A total of 120 patients who had received moderate to major abdominal surgery and then transferred to the intensive care unit (ICU) from January 2008 to October 2018 were retrospectively analyzed. The peri-operative parameters of serum inorganic phosphate and calcium levels were recorded and analyzed. The incidence of hypophosphatemia after the operation was calculated. The effect of phosphorus-supplement infusion on the complications and mortality within 30 days after the operation were observed. \u0000 \u0000 \u0000Results \u0000After moderate-to-major surgery, the phosphorus concentration significantly decreased [(1.21±0.27) vs. (0.83±0.24)mmol/L, P<0.05]; the incidence of hypophosphatemia was 58.3%, especially in patients with nutritional risk assessed before the operation. The post-operative complications were less in the phosphorus-supplement infusion group than in the control group (17.5% vs. 41.3%, P=0.028). \u0000 \u0000 \u0000Conclusion \u0000The incidence of hypophosphatemia is relatively high after moderate-to-major abdominal surgery, especially in patients with nutritional risks. The treatment of phosphorus-supplement infusion can benefit the patients in their short-term prognosis. \u0000 \u0000 \u0000Key words: \u0000Hypophosphatemia; Critically ill; Nutritional risk","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"338-341"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42994371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.06.001
Chun-hong Hao, Xiaomeng Li, Zhenshui Li, Yin-yin Xu, Li Wang, Lei Feng, Xiang Li, Yang Wang, Yanyan Zhao, Xianna Zhang, Jian Yang, Zhuo Li
Objective To investigate the prevalence of nutritional risk(NRS2002) and malnutrition in hospitalized stroke patient and their nutritional intervention. Methods The stroke patients admitted to three departments of vascular neurology ward including cerebral hemorrhage, cerebral infarction and subarachnoid hemorrhage in Beijing Tiantan Hospital from January 2018 to January 2019 were recruited using cluster sampling. Nutritional risk screening 2002 (NRS 2002) was used to screen the nutritional risk of inpatients Malnutrition was assessed by criteria: (1)body mass index (BMI) <18.5 kg/m2 with poorer general condition from January 2018 to January 2019; (2)Global leadership initiative on malnutrition(GLIM)criteria were used except whole body muscle mass measurement from October 2018 to January 2019. The nutritional intervention for patients were closely observed during hospitalization. Results A total of 1 532 patients were registered and 1 036 patients were included in the final analysis considering the inclusion and exclusion criteria.The prevalence of nutritional risk was 33.0%(342/1 036). The prevalence of malnutrition based on BMI and GLIM criteria was 0.9% (9/1 036) and 2.5% (10/393) respectively. Among the 342 patients with nutritional risk, 112 patients received nutritional support therapy by tube feeding, but only 29 patients received nutritional support that met guideline standards.81 patients received not standard nutritional support, and 2 patients received highly unregulated nutritional support. No patients received sugar and electrolyte infusion, oral nutritional supplements (ONS), oral nutritional agents and compound nutrition intervention. The other 230 patients took hospital diet. Conclusion The prevalence of nutritional risk in hospitalized patients with cerebral hemorrhage, cerebral infarction or subarachnoid hemorrhage was high, and the prevalence of malnutrition was extremely low. There was a low proportion of nutritional support.High quality of large sample cohort studies will be conducted to show whether reasonable application of nutritional support therapy in patients with nutritional risk can improve patient outcome. Key words: Cerebralhemorrhage; Cerebral infarction; Subarachnoid hemorrhage; Prevalence ofnutritional risk; Prevalence ofmalnutrition; Classification of nutritional intervention; Stroke
{"title":"Prevalence of nutritional risk and malnutrition and observation of nutritional intervention in hospitalized patients with stroke in a teaching hospital in Beijing","authors":"Chun-hong Hao, Xiaomeng Li, Zhenshui Li, Yin-yin Xu, Li Wang, Lei Feng, Xiang Li, Yang Wang, Yanyan Zhao, Xianna Zhang, Jian Yang, Zhuo Li","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.06.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.06.001","url":null,"abstract":"Objective \u0000To investigate the prevalence of nutritional risk(NRS2002) and malnutrition in hospitalized stroke patient and their nutritional intervention. \u0000 \u0000 \u0000Methods \u0000The stroke patients admitted to three departments of vascular neurology ward including cerebral hemorrhage, cerebral infarction and subarachnoid hemorrhage in Beijing Tiantan Hospital from January 2018 to January 2019 were recruited using cluster sampling. Nutritional risk screening 2002 (NRS 2002) was used to screen the nutritional risk of inpatients Malnutrition was assessed by criteria: (1)body mass index (BMI) <18.5 kg/m2 with poorer general condition from January 2018 to January 2019; (2)Global leadership initiative on malnutrition(GLIM)criteria were used except whole body muscle mass measurement from October 2018 to January 2019. The nutritional intervention for patients were closely observed during hospitalization. \u0000 \u0000 \u0000Results \u0000A total of 1 532 patients were registered and 1 036 patients were included in the final analysis considering the inclusion and exclusion criteria.The prevalence of nutritional risk was 33.0%(342/1 036). The prevalence of malnutrition based on BMI and GLIM criteria was 0.9% (9/1 036) and 2.5% (10/393) respectively. Among the 342 patients with nutritional risk, 112 patients received nutritional support therapy by tube feeding, but only 29 patients received nutritional support that met guideline standards.81 patients received not standard nutritional support, and 2 patients received highly unregulated nutritional support. No patients received sugar and electrolyte infusion, oral nutritional supplements (ONS), oral nutritional agents and compound nutrition intervention. The other 230 patients took hospital diet. \u0000 \u0000 \u0000Conclusion \u0000The prevalence of nutritional risk in hospitalized patients with cerebral hemorrhage, cerebral infarction or subarachnoid hemorrhage was high, and the prevalence of malnutrition was extremely low. There was a low proportion of nutritional support.High quality of large sample cohort studies will be conducted to show whether reasonable application of nutritional support therapy in patients with nutritional risk can improve patient outcome. \u0000 \u0000 \u0000Key words: \u0000Cerebralhemorrhage; Cerebral infarction; Subarachnoid hemorrhage; Prevalence ofnutritional risk; Prevalence ofmalnutrition; Classification of nutritional intervention; Stroke","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"331-337"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41712187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.06.011
Huazhen Liu, Naishi Li
Autoantibodies are related to occurrence of some types of severe hypertriglyceridemia. Researches showed that autoantibodies of lipoprotein lipase, glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 and apolipoprotein C-Ⅱ could induce hypertriglyceridemia. This review focused on hypertriglyceridemia induced by autoantibodies and its treatment. Key words: Hypertriglyceridemia; Autoantibody; Glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1; Lipoprotein lipase; Apolipoprotein C-Ⅱ
{"title":"Autoantibodies and hypertriglyceridemia","authors":"Huazhen Liu, Naishi Li","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.06.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.06.011","url":null,"abstract":"Autoantibodies are related to occurrence of some types of severe hypertriglyceridemia. Researches showed that autoantibodies of lipoprotein lipase, glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 and apolipoprotein C-Ⅱ could induce hypertriglyceridemia. This review focused on hypertriglyceridemia induced by autoantibodies and its treatment. \u0000 \u0000 \u0000Key words: \u0000Hypertriglyceridemia; Autoantibody; Glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1; Lipoprotein lipase; Apolipoprotein C-Ⅱ","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"389-392"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48666752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To explore the high-risk factors of metabolic bone disease(MBD)in premature infants by retrospective analysis of the clinical data so as to provide evidence for optimal clinical management. Methods Clinical data of premature infants with birth weight 500 IU/L and blood phosphorus <1.5 mmol/L were selected as MBD group and premature infants with birth weight <1 500 g were selected randomly as non-MBD group. General data, pulmonary surfactant, continuous positive airway pressure, mechanical ventilation, start time of enteral nutrition, parenteral nutrition (PN) time, breast feeding time and breast milk fortifier adding, drug usage, hospitalization time and complications were recorded and compared between the two groups. Results A total of 440 premature infants with birth weight <1 500 g were admitted to the hospital during the study period. 58[13.2%(58/440)] infants were enrolled in the MBD group, among which infants with birth weight <1 000 g accounting for 56.9%(33/58). High birth weight (OR=0.62, 95% CI: 0.389-0.990) was an independent protective factor of MBD in premature infants. The higher the birth weight, the lower the risk of MBD in premature infants. The longer duration of breast feeding time(OR= 2.191, 95% CI: 1.628-2.950), later initial time of enteral feeding(OR=2.695, 95% CI: 1.710-4.248), longer duration of PN(OR=6.205, 95% CI: 3.359-11.463) time, longer duration of respiratory supporting time(OR=1.046, 95% CI: 1.026-.067), longer hospital stay time(OR=1.703, 95% CI: 1.109-2.615) and small for gestational age(OR=2.965, 95% CI: 1.163-5.658) were independent risk factors of MBD in premature infants. The duration of PN was the most important independent risk factor of MBD in premature infants(OR=6.205, 95% CI: 3.359-11.463). Conclusion Multiple factors can lead to MBD of premature infants. The high birth weight is an independent protective factor of MBD and the duration of PN is the most important independent risk factor of MBD in premature infants. Key words: Premature infant; Metabolic bone disease; High risk factor
{"title":"Clinical high-risk factors of metabolic bone disease in very low birth weight infants","authors":"Jiaxin Xu, Lin Xianghong, Xiaohu Wang, Xian-hong Yin, Hongmin Xi, Rui Yuan","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.06.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.06.008","url":null,"abstract":"Objective \u0000To explore the high-risk factors of metabolic bone disease(MBD)in premature infants by retrospective analysis of the clinical data so as to provide evidence for optimal clinical management. \u0000 \u0000 \u0000Methods \u0000Clinical data of premature infants with birth weight 500 IU/L and blood phosphorus <1.5 mmol/L were selected as MBD group and premature infants with birth weight <1 500 g were selected randomly as non-MBD group. General data, pulmonary surfactant, continuous positive airway pressure, mechanical ventilation, start time of enteral nutrition, parenteral nutrition (PN) time, breast feeding time and breast milk fortifier adding, drug usage, hospitalization time and complications were recorded and compared between the two groups. \u0000 \u0000 \u0000Results \u0000A total of 440 premature infants with birth weight <1 500 g were admitted to the hospital during the study period. 58[13.2%(58/440)] infants were enrolled in the MBD group, among which infants with birth weight <1 000 g accounting for 56.9%(33/58). High birth weight (OR=0.62, 95% CI: 0.389-0.990) was an independent protective factor of MBD in premature infants. The higher the birth weight, the lower the risk of MBD in premature infants. The longer duration of breast feeding time(OR= 2.191, 95% CI: 1.628-2.950), later initial time of enteral feeding(OR=2.695, 95% CI: 1.710-4.248), longer duration of PN(OR=6.205, 95% CI: 3.359-11.463) time, longer duration of respiratory supporting time(OR=1.046, 95% CI: 1.026-.067), longer hospital stay time(OR=1.703, 95% CI: 1.109-2.615) and small for gestational age(OR=2.965, 95% CI: 1.163-5.658) were independent risk factors of MBD in premature infants. The duration of PN was the most important independent risk factor of MBD in premature infants(OR=6.205, 95% CI: 3.359-11.463). \u0000 \u0000 \u0000Conclusion \u0000Multiple factors can lead to MBD of premature infants. The high birth weight is an independent protective factor of MBD and the duration of PN is the most important independent risk factor of MBD in premature infants. \u0000 \u0000 \u0000Key words: \u0000Premature infant; Metabolic bone disease; High risk factor","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"374-380"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45829297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the effects of vitamin D3 supplementation combined with standardized hypoglycemic regimen on islet β cell function and macroangiopathy of T2DM patients. Methods A total of 192 patients with type 2 diabetes mellitus were selected and randomly divided into control group and observation group with 96 patients in each group. Patients in two groups were given standardized hypoglycemic regimen, and the observation group was treated with vitamin D3 supplementation in addition. The changes of the indexes of body examination, glycolipid metabolism, islet β cell function and macrovascular complications before and 6 months after treatment were compared between the two groups. Results After 6 months of treatment, BMI, SBP, TG, FBG, FINS, HbA1c and HOMA-IR decreased, while HOMA-β increased in both groups (P<0.05). Compared with the control group, the serum levels of 25 (OH) D increased, and vaspin and CRP decreased significantly after 6 months of treatment in the observation group (P<0.05). CIMT and other indicators showed no significant difference. 25 (OH) D was negatively correlated with FBG, FINS, vaspin and CRP, and positively correlated with 1PH and ISI (P<0.05). Conclusion Vitamin D3 is closely related to T2DM and its macrovascular complications, but it has not been found that vitamin D3 supplementation can further improve islet β cell function and macrovascular complications in patients with T2DM. Key words: Type 2 diabetes; Vitamin D; Islet Cell Function; Macroangiopathy; Vaspin
{"title":"Effects of vitamin D3 supplementation combined with standardized hypoglycemic regimen on islet β cell function and macrovascular complications in newly diagnosed type 2 diabetes mellitus","authors":"Shiwei Liu, Ruixue Duan, Xin Li, Jiaxin Zhang, Yaru Wu","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.06.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.06.005","url":null,"abstract":"Objective \u0000To investigate the effects of vitamin D3 supplementation combined with standardized hypoglycemic regimen on islet β cell function and macroangiopathy of T2DM patients. \u0000 \u0000 \u0000Methods \u0000A total of 192 patients with type 2 diabetes mellitus were selected and randomly divided into control group and observation group with 96 patients in each group. Patients in two groups were given standardized hypoglycemic regimen, and the observation group was treated with vitamin D3 supplementation in addition. The changes of the indexes of body examination, glycolipid metabolism, islet β cell function and macrovascular complications before and 6 months after treatment were compared between the two groups. \u0000 \u0000 \u0000Results \u0000After 6 months of treatment, BMI, SBP, TG, FBG, FINS, HbA1c and HOMA-IR decreased, while HOMA-β increased in both groups (P<0.05). Compared with the control group, the serum levels of 25 (OH) D increased, and vaspin and CRP decreased significantly after 6 months of treatment in the observation group (P<0.05). CIMT and other indicators showed no significant difference. 25 (OH) D was negatively correlated with FBG, FINS, vaspin and CRP, and positively correlated with 1PH and ISI (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Vitamin D3 is closely related to T2DM and its macrovascular complications, but it has not been found that vitamin D3 supplementation can further improve islet β cell function and macrovascular complications in patients with T2DM. \u0000 \u0000 \u0000Key words: \u0000Type 2 diabetes; Vitamin D; Islet Cell Function; Macroangiopathy; Vaspin","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"354-360"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49600495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.06.009
Chen Ping, Wu Guimei, Hao Yun
Objective To explore the clinical application of intracavitary electrocardiogram in positioning of PICC catheter tip through inferior vena cava and summarize the change rule of electrocardiographic wave during the PICC process. Methods 60 patients who couldn′t receive PICC through precava were recruited from a tertiary hospital and assigned into the intervention group and the control group randomly. Patients in the control group received PICC through inferior vena cava and X-ray was used to confirm the positioning of PICC catheter tip. Patients in the intervention group were checked by intracavitary electrocardiogram. Success rates were compared and the change rule of electrocardiographic wave during the PICC process was summarized. Results The success rate was 100% in the intervention group and 86.7% in the control group. All patients in the intervention group showed the typical change of intracavitary electrocardiogram. Conclusions Intracavitary electrocardiogram can promote success rate of PICC through inferior vena cava and reduce the side effect. It is of great value to generalize intracavitary electrocardiogram in clinical application. Key words: Intracavitary electrocardiogram; PICC through inferior vena cava; Positioning of PICC catheter tip
{"title":"Clinical application of intracavitary electrocardiogram in positioning of PICC catheter tip through inferior vena cava","authors":"Chen Ping, Wu Guimei, Hao Yun","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.06.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.06.009","url":null,"abstract":"Objective \u0000To explore the clinical application of intracavitary electrocardiogram in positioning of PICC catheter tip through inferior vena cava and summarize the change rule of electrocardiographic wave during the PICC process. \u0000 \u0000 \u0000Methods \u000060 patients who couldn′t receive PICC through precava were recruited from a tertiary hospital and assigned into the intervention group and the control group randomly. Patients in the control group received PICC through inferior vena cava and X-ray was used to confirm the positioning of PICC catheter tip. Patients in the intervention group were checked by intracavitary electrocardiogram. Success rates were compared and the change rule of electrocardiographic wave during the PICC process was summarized. \u0000 \u0000 \u0000Results \u0000The success rate was 100% in the intervention group and 86.7% in the control group. All patients in the intervention group showed the typical change of intracavitary electrocardiogram. \u0000 \u0000 \u0000Conclusions \u0000Intracavitary electrocardiogram can promote success rate of PICC through inferior vena cava and reduce the side effect. It is of great value to generalize intracavitary electrocardiogram in clinical application. \u0000 \u0000 \u0000Key words: \u0000Intracavitary electrocardiogram; PICC through inferior vena cava; Positioning of PICC catheter tip","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"381-384"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47627576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.06.004
Jingjing Lu, Yeqing Liu, Jie Zhang, Pingping Lou, Yan Liu
Objective To explore the intervention effect of low-dose vitamin D on glucose metabolism of patients with impaired glucose regulation. Methods A total of 196 subjects receiving oral glucose tolerance test were enrolled in this study, including individuals with normal glucose tolerance (NGT group, n=67) and individuals with impaired glucose regulation (IGR group, n=129). The IGR group was divided into intervention group (n=64)and non-intervention group (n=65) according to vitamin D intervention (for 1 year) performed or not. Clinical data and biochemical parameters were collected. Results The level of serum 25(OH)D3 was significantly lower in the IGR group than that of normal control group (P<0.05). After 1 year of low-dose vitamin D intervention, insulin sensitivity increased and insulin resistance decreased in the intervention group as compared with non-intervention group. Diabetes developed less frequently in the intervention group (25 of 64 [39.1%]) compared with non-intervention group (30 of 65 [46.2%]). But there was no significant different in diabetes prevalence between the two groups. Conclusions Vitamin D intervention can improve insulin sensitivity and reduce insulin resistance in patients with impaired glucose regulation. Low dose vitamin D can improve the abnormal glucose metabolism outcome in patients with impaired glucose regulation. Key words: vitamin D; 25(OH)D3; type 2 diabetes mellitus; insulin secretion
{"title":"Effect of vitamin D intervention on the outcome of glucose metabolism in patients with impaired glucose regulation","authors":"Jingjing Lu, Yeqing Liu, Jie Zhang, Pingping Lou, Yan Liu","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.06.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.06.004","url":null,"abstract":"Objective \u0000To explore the intervention effect of low-dose vitamin D on glucose metabolism of patients with impaired glucose regulation. \u0000 \u0000 \u0000Methods \u0000A total of 196 subjects receiving oral glucose tolerance test were enrolled in this study, including individuals with normal glucose tolerance (NGT group, n=67) and individuals with impaired glucose regulation (IGR group, n=129). The IGR group was divided into intervention group (n=64)and non-intervention group (n=65) according to vitamin D intervention (for 1 year) performed or not. Clinical data and biochemical parameters were collected. \u0000 \u0000 \u0000Results \u0000The level of serum 25(OH)D3 was significantly lower in the IGR group than that of normal control group (P<0.05). After 1 year of low-dose vitamin D intervention, insulin sensitivity increased and insulin resistance decreased in the intervention group as compared with non-intervention group. Diabetes developed less frequently in the intervention group (25 of 64 [39.1%]) compared with non-intervention group (30 of 65 [46.2%]). But there was no significant different in diabetes prevalence between the two groups. \u0000 \u0000 \u0000Conclusions \u0000Vitamin D intervention can improve insulin sensitivity and reduce insulin resistance in patients with impaired glucose regulation. Low dose vitamin D can improve the abnormal glucose metabolism outcome in patients with impaired glucose regulation. \u0000 \u0000 \u0000Key words: \u0000vitamin D; 25(OH)D3; type 2 diabetes mellitus; insulin secretion","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"349-353"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47071421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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