Association of serum uric acid with risk of vertebral fracture in patients with type 2 diabetes

Q4 Medicine 中华内分泌代谢杂志 Pub Date : 2020-04-25 DOI:10.3760/CMA.J.CN311282-20190703-00254

X. Deng, Pengxu Wang, Huijuan Yuan

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Abstract

The clinical data of 239 inpatients with type 2 diabetes in Endocrinology Department of Henan Provincial People′s Hospital from January to February 2017 were collected. A total of 170 subjects were included in the final analysis. One diabetes-specific vertebral facture risk estimation called risk score for vertebral fracture was used to estimate the risk of vertebral fracture. Multivariate linear regression analysis was used to calculate the association of serum uric acid with risk of vertebral fracture. The mean age of subjects in final analysis was 56.5±26.4 years old, with the duration of diabetes 8.6±7.1 years and the vertebral fracture risk score 5.6±4.0. Additionally, there was a negative linear correlation between serum uric acid and vertebral fracture risk score in patients with type 2 diabetes(Ptrend=0.021) independent of age, gender, systolic blood pressure, HbA1C, course of diabetes, obesity status, total cholesterol, and estimated glomerular filtration rate(P=0.033). Multivariate linear regression indicated that age, course of diabetes, blood pressure, total cholesterol, serum albumin, T score at femoral neck were related to the vertebral fracture risk score. Key words: Uric acid; Diabetes mellitus, type 2; Fracture

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血清尿酸与2型糖尿病患者椎体骨折风险的关系

收集2017年1 - 2月河南省人民医院内分泌科239例2型糖尿病住院患者的临床资料。总共170名受试者被纳入最终分析。一种糖尿病特异性椎体骨折风险评估称为椎体骨折风险评分，用于评估椎体骨折的风险。采用多元线性回归分析计算血清尿酸与椎体骨折风险的关系。最终分析受试者的平均年龄为56.5±26.4岁，糖尿病病程8.6±7.1年，椎体骨折风险评分5.6±4.0分。此外，血清尿酸与2型糖尿病患者椎体骨折风险评分呈负线性相关(P趋势=0.021)，与年龄、性别、收缩压、HbA1C、糖尿病病程、肥胖状况、总胆固醇和肾小球滤过率估计值无关(P=0.033)。多因素线性回归显示，年龄、糖尿病病程、血压、总胆固醇、血清白蛋白、股骨颈T评分与椎体骨折危险评分相关。关键词:尿酸;2型糖尿病;骨折

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来源期刊

中华内分泌代谢杂志 Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

0.60

自引率

0.00%

发文量

7243

期刊介绍： The Chinese Journal of Endocrinology and Metabolism was founded in July 1985. It is a senior academic journal in the field of endocrinology and metabolism sponsored by the Chinese Medical Association. The journal aims to be the "Chinese broadcaster of new knowledge on endocrinology and metabolism worldwide". It reports leading scientific research results and clinical diagnosis and treatment experience in endocrinology and metabolism and related fields, as well as basic theoretical research that has a guiding role in endocrinology and metabolism clinics and is closely integrated with clinics. The journal is a core journal of Chinese science and technology (a statistical source journal of Chinese science and technology papers), and is included in Chinese and foreign statistical source journal databases such as the Chinese Science and Technology Papers and Citation Database, Chemical Abstracts, and Scopus.