中华内分泌代谢杂志最新文献

{"title":"Correlation analysis between serum uric acid and clinical features of patients with novel coronavirus pneumonia","authors":"Z. Xu, X. Chen, P. Wang, Yongwei Zhao, X. Fan","doi":"10.3760/cma.j.cn311282-20201022-00700","DOIUrl":"https://doi.org/10.3760/cma.j.cn311282-20201022-00700","url":null,"abstract":"Objective: To analyze the correlation between serum uric acid and clinical features of patients with novel coronavirus pneumonia(COVID-19). Methods: A total of 200 patients with COVID-19 admitted to Wuhan Lei Shen Shan hospital from January 20, 2020 to April 10, 2020 were included in this retrospective cohort study. The patients were divided into the hyperuricemia group and the non-hyperuricemia group. The data of patients were collected through electronic medical record system. SPSS 19.0 and Graphpad Prism 8.0 statistical software were used to compare clinical features, laboratory results, survival time, and prognosis of patients between hyperuricemia and non-hyperuricemia groups. Results: Compared with the non-hyperuricemia group, the hyperuricemia group showed a higher BMI and mortality(P <0.05)as well as higher white blood cell count, lymphocytes, serum creatinine, creatine kinase, cystatin C, myoglobin, interleukin(IL)-6 levels(P <0.05). Serum uric acid level was positively correlated with lymphocytes, hemoglobin, albumin, creatinine, creatine kinase, cystatin C, D-dimer levels while negatively correlated with IL-2 receptor and IL-8. The patients with hyperuricemia had significantly shorter survival time and worse prognosis than those without hyperuricemia(P =0.04). Conclusion: COVID-19 patients with hyperuricemia show higher mortality and worse prognosis compared with the patients with non-hyperuricemia. Copyright © 2021 by the Chinese Medical Association.","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"37 1","pages":"631-636"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70011272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on glycemic profiles and emotional scales in diabetic patients after the outbreak of COVID-19","authors":"Xiaoxu Sun, Fanghong Shi, Jing Ma, Minglan Yang, W. Liu, Lihua Wang, Wei Liu","doi":"10.3760/CMA.J.CN311282-20200611-00431","DOIUrl":"https://doi.org/10.3760/CMA.J.CN311282-20200611-00431","url":null,"abstract":"Objective: To observe the glycemic profiles and emotion management in diabetic patients after the outbreak of novel coronavirus disease 2019(COVID-19) Methods: A questionnaire survey was used to observe the blood glucose levels and metabolic indexes before and after the outbreak of COVID-19, and to detect emotion ratings after the outbreak of COVID-19 The aim of the study is to present the effects of the COVID-19 on glycemic and emotional management in diabetic patients Results: A total of 136 patients were included in this survey The average age of the patients was 62 5 years old, and the average duration of diabetes was 10 1 years Glycemic profiles(fasting blood glucose, 2 h postprandial blood glucose, HbA1C), lipid profiles(triglycerides, low-density lipoprotein cholesterol), and body weight were not significantly different before and after the outbreak of COVID-19(P>0 05) According to emotional scales(scores of anxiety, depression, and sleep-related scales), 76 5% diabetic patients did not develop anxiety symptoms, 61 0%~69 9% diabetic patients did not have depressive symptoms and 52 0% diabetic patients did not have sleep disorder 19 9% diabetic patients had mild anxiety symptoms, 25 7%~30 9% diabetic patients presented mild depression symptoms and 28 3% diabetic patients had mild sleep disorders 2 9% diabetic patients had moderate anxiety, 2 2%~8 1% diabetic patients had moderate depression and 14 2% diabetic patients had moderate sleep disorder Only a very small part of patients presented severe emotional symptoms including 0 7% patients with anxiety symptoms(GAD-7 15 points and above), 2 2% patients with depressive symptoms(PHQ9 and PHQ15 15 points and above)and 5 6% patients with sleep symptoms(PSQI 15 points and above) Compared with asymptomatic patients, neither patients with mild and moderate/severe depression and sleep disorder showed significant difference in HbA1C, nor did patients with moderate/ severe anxiety symptoms However, patients with mild anxiety symptoms showed significant lower HbA1C than asymptomatic patients Conclusion: After the outbreak of COVID-19, there was an increasing trend in blood glucose, but there was no statistical difference Body weight, lipids profiles were not different in diabetic patients, either Most of diabetic patients had mild symptoms of anxiety, depression and sleep disorders Very few patients presented moderate to severe symptoms of anxiety, depression and sleep disorders Copyright © 2020 by the Chinese Medical Association","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"36 1","pages":"673-677"},"PeriodicalIF":0.0,"publicationDate":"2020-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46290844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interrelationship between 2019-nCoV receptor ACE2 and diabetes mellitus target based on protein interaction network","authors":"Jiacheng Shui, Rensong Yue","doi":"10.3760/CMA.J.CN311282-20200223-00093","DOIUrl":"https://doi.org/10.3760/CMA.J.CN311282-20200223-00093","url":null,"abstract":"Objective: Exploring the relationship between diabetes mellitus targets and ACE2 of the receptor of novel coronavirus(2019-nCoV) through a protein interaction network to provide new perspectives for clinical use Methods: Diabetes mellitus targets were obtained from the GeneCards and OMIM databases Targets with a relevance score exceeding 10 were included, and ACE2 protein was manually added The initial protein interaction network was obtained through String and then imported into Cytoscape 3 7 1 We selected the protein targets directly related to ACE2 as the target of the final analysis and imported them into String again in order to obtain the protein interaction network Module identification, GO analysis and KEGG pathway analysis were performed respectively The impact of ACE2 on the entire network was analyzed by scoring the module where it located Results: 19 ACE2-related proteins were finally selected from diabetes mellitus targets Three functional modules were found through the cluster analysis These modules involved G protein-coupled receptor binding, antioxidant activity, and insulin-like growth factor receptor binding The main signal pathways involved were the renin angiotensin system signal pathway, the type 2 diabetes mellitus signal pathway, and the FOXA2 signal pathway The scoring results showed that REN, AGT, INS, NOS3, IL6, and CRP scored the highest Conclusions: ACE2 is widely associated with diabetes mellitus key proteins COVID-19 may impact RAS of diabetes mellitus patients then induce serious complications Clinical use of RAS inhibitors may reduce the impact of COVID-19 infection on diabetes mellitus patients Copyright © 2020 by the Chinese Medical Association","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"36 1","pages":"678-683"},"PeriodicalIF":0.0,"publicationDate":"2020-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48529723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflections on the management of a novel coronavirus pneumonia patient with refractory hyperglycemia","authors":"Zubo Shen, F. Xie, J. Zhong, Si-Ming Huang, H. Tang, D. Ji, Xiaoyun Fu","doi":"10.3760/CMA.J.ISSN.1000-6699.2020.0004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6699.2020.0004","url":null,"abstract":"","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47000033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic analysis of Gitelman syndrome in a patient with recurrent spontaneous abortion","authors":"Q. Yuan, Huijuan Yuan, R. Zheng","doi":"10.3760/CMA.J.CN311282-20190822-00336","DOIUrl":"https://doi.org/10.3760/CMA.J.CN311282-20190822-00336","url":null,"abstract":"Sanger sequencing was applied to analyze the SLC12A3 gene of a patient with suspected Gitelman syndrome(GS) and recurrent spontaneous abortions, as well as for her parents. The results showed that a compound heterozygous mutation(c.1077C>G, c.2890C>T) was found in the proband, which led to the change of amino acid sequence(p.N359K, p.R964W). Among the family members, her mother was a single heterozygotes mutation carrier of c. 1077C>G(p.N359K) and her father had c. 2890C>T(p.R964W) heterozygotes.These results suggest that the GS may cause adverse pregnancy outcomes due to imbalance of internal environment, complex hormonal changes, and electrolyte abnormalities. The pregnancy management should be strengthened. \u0000 \u0000Key words: \u0000Gitelman syndrome; SLC12A3 gene; Hypokalemia; Recurrent spontaneous abortion","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"36 1","pages":"333-336"},"PeriodicalIF":0.0,"publicationDate":"2020-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45209473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pituitary abscess: Report of three cases","authors":"Xiaojuan Du, Wei Lin, Liangchun Cai, Nengying Wang, J. Wen, Gang Chen","doi":"10.3760/CMA.J.CN311282-20190613-00224","DOIUrl":"https://doi.org/10.3760/CMA.J.CN311282-20190613-00224","url":null,"abstract":"Pituitary abscess is a rare but potentially life-threatening disease. Headache, visual disturbance, and hypopituitarism are the most common presenting symptoms of pituitary abscess. On magnetic resonance imaging(MRI), pituitary abscess may present as a round sellar cystic lesion, hypo- or isointense on T1 imaging and hyper- or isointense on T2 imaging with peripheral gadolinium enhancement. Diagnosis usually is made during surgical exploration when pus is found in a cystic lesion. The mainstay of treatment is transsphenoidal surgical resection in combination with antibiotic therapy, although a craniotomy approach is warranted in select conditions. Here we report 3 cases of pituitary abscess in our hospital and review the literatures. \u0000 \u0000Key words: \u0000Pituitary abscess; MRI; Diagnosis; Therapy","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"36 1","pages":"337-341"},"PeriodicalIF":0.0,"publicationDate":"2020-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47905562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clitoromegaly diagnosis and treatment","authors":"Miaoling Huang, N. Ding, Jian Lin, Zhifeng Sheng","doi":"10.3760/CMA.J.CN311282-20190408-00123","DOIUrl":"https://doi.org/10.3760/CMA.J.CN311282-20190408-00123","url":null,"abstract":"Clitoris lesion is most readily classified into hormone-dependent and hormone-independent cause. It can also be characterized as congenital or acquired nature. Clitoromegaly is the most common presentation of clitoral lesions clinically. Hormone-dependent clitoromegaly is mainly attibuted to the increase of androgen, while the most comomon cause of hormone-independent clitoromegaly is neurofibromatosis. Except that, there are so many other disorders which can cause clitoromegaly, leading to the difficulty for diagnosis. However, the literature concerning the management of clitoromegaly is scarce.The present study summarized the lesions of clitoromegaly from the etiology, diagnosis, and differential diagnosis to treatment. This may help clinicians to make a reasonbale management when facing this kind of disease. \u0000 \u0000Key words: \u0000Clitoromegaly; Hormone-dependent; Hormone-independent; Diagnosis; Treament","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"36 1","pages":"361-364"},"PeriodicalIF":0.0,"publicationDate":"2020-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41789477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex multiple endocrine neoplasia type 1 with rare components: one case report","authors":"Zhuo-na Yin, Wensheng Jin, Jiahui Dong, Hongbing Zhang, Hongmei Li, Qirui Fu, Song Zhang, Jie Sun","doi":"10.3760/CMA.J.CN311282-20190715-00272","DOIUrl":"https://doi.org/10.3760/CMA.J.CN311282-20190715-00272","url":null,"abstract":"","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"36 1","pages":"342-347"},"PeriodicalIF":0.0,"publicationDate":"2020-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45963329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages and disadvantages of menopause hormone therapy","authors":"Wei Liu, T. Tao, Yideng Qi","doi":"10.3760/CMA.J.CN311282-20190721-00285","DOIUrl":"https://doi.org/10.3760/CMA.J.CN311282-20190721-00285","url":null,"abstract":"With the extension of life expectancy and increased attention to quality of life, females pay more attention to physical and mental health problems, such as a variety of menopause-related symptoms, tissue atrophic degradation and metabolic dysfunction brought by ovarian hypofunction. Menopause hormone therapy(MHT) is the most effective method to alleviate the symptoms associated with ovarian dysfunction, and it can also prevent the occurrence of age-related chronic diseases in the early menopause stage. Some clinical studies showed that MHT increased the risks of gynecological related tumors, cardiovascular and cerebrovascular diseases, which limited the clinical application of MHT and prevented some patients who need MHT from getting timely treatment. However, with the standardization of therapeutic schedule, the effectiveness and safety of MHT application have been greatly improved. This article summarizes the current clinical research results together with the benefits and risks of MHT. \u0000 \u0000Key words: \u0000Menopause; Menopause hormone therapy; Tumors; Cardiovascular and cerebrovascular diseases","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"36 1","pages":"277-282"},"PeriodicalIF":0.0,"publicationDate":"2020-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47168558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between abdominal fat distribution and diabetic complications in patients with type 2 diabetes mellitus","authors":"Huiqin Xiong, Pengyu Zhang, Xia-lian Li, Hui-juan Zhang, Liguo Yang, Yan Wu, Liangge Sun, G. Qin","doi":"10.3760/CMA.J.CN311282-20191120-00500","DOIUrl":"https://doi.org/10.3760/CMA.J.CN311282-20191120-00500","url":null,"abstract":"Objective \u0000To investigate the association of abdominal fat distribution with glycolipid metabolism and diabetic complications in patients with T2DM. \u0000 \u0000 \u0000Methods \u0000Totally 357 inpatients with T2DM were collected from the Endocrinology Department of our hospital. All patients received quantitative computed tomography to measure the visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), and were divided into three groups depending on the tertile of VAT value: T1 group (VAT<162.0 cm2), T2 group (162.0≤VAT<221.1 cm2), T3 group (VAT≥221.1 cm2). The incidences of diabetic kidney disease, diabetic retinopathy, diabetic peripheral neuropathy, peripheral atherosclerosis, and cardia-cerebrovascular disease were examined in all patients. \u0000 \u0000 \u0000Results \u0000HbA1C level in T1 group was higher than that in T3 group(P<0.05). High density lipoprotein-cholesterol (HDL-C) and estimated glomerular filtration rate (eGFR) in T1 group were higher compared with those in T2 and T3 groups (P<0.05). Male proportion, age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), 24h urinary albumin, diabetic kidney disease and peripheral atherosclerosis in T2 and T3 groups were higher than those in T1 group (P<0.05). Fasting C- peptide (FCP) and modified homeostasis model assessment for insulin resistance (HOMA-IR) in T3 group were higher than those in T1 and T2 group (P<0.01). VAT and SAT were positively correlated with BMI, FCP, and HOMA-IR (p<0.01). VAT was positively correlated with age, SBP, DBP, TG, 24h urinary albumin, diabetic kidney disease, peripheral atherosclerosis, and cardia-cerebrovascular disease (P<0.05), while inversely correlated with HbA1C, HDL-C, and eGFR (P<0.05). SAT was positively correlated with total cholesterol and low density lipoprotein-cholesterol (P<0.01), while negatively correlated with peripheral atherosclerosis (P<0.01). Multivariate logistic regression analysis showed that VAT was still a risk factor for diabetic kidney disease after adjusted by age, BMI, SBP and fasting plasma glucose(P=0.013). \u0000 \u0000 \u0000Conclusion \u0000VAT and SAT are associated with blood lipids and insulin resistance, while VAT seems to be a risk factor for diabetic kidney disease. \u0000 \u0000 \u0000Key words: \u0000Abdominal fat area; Diabetes mellitus, type 2; Diabetic complications; Quantitative computed tomography","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"36 1","pages":"299-303"},"PeriodicalIF":0.0,"publicationDate":"2020-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47027916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}