Distribution of Multilayered Fiber Terminals in the Human Cerebellar Cortex. Visualization by Immunohistochemistry for Histamine

Abstract

The distribution of histamine in the human cerebellar cortex was studied by light microscope immunohistochemistry using a rabbit polyclonal antibody anti-histamine. In all layers of the cerebellar cortex, were revealed punctate immunoreactive elements related to putative histaminergic nerve terminals. These findings provide insights into the existence of a histaminergic system in the human cerebellar cortex, presumably involved in the cerebrocerebellar circuit, the feedback circuit through which the cerebellum is widely connected with the neocortex and the hypothalamus and intervene in the regulation of motor and non-motor functions.