Angelica sinensis polysaccharide promotes the proliferation and osteogenic differentiation of human dental pulp stem cells (hDPSCs) by activating the wnt/β-catenin pathway

IF 4.6 3区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Quality Assurance and Safety of Crops & Foods Pub Date : 2021-11-26 DOI:10.15586/qas.v13i4.989

Tiantian Mao, Youjian Peng, Ruobing Peng, Xiaoying Wei

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引用次数: 2

Abstract

Human dental pulp stem cells (hDPSCs) are capable of forming mineralized nodules. The proliferation and osteogenic differentiation of hDPSCs are very important for alleviating tooth defects caused by related diseases. Angel-ica polysaccharide (ASP) is the main bioactive ingredient extracted from the angelica root. ASP has a variety of biological functions, including immune regulation, antitumor activity, and hematopoiesis. However, its possible effects on hDPSCs are still unclear. In this study, we aimed to investigate the role of ASP in periodontal diseases. We found that ASP promoted the proliferation of hDPSCs and osteogenic differentiation of hDPSCs. We further found that it promoted the expression of osteogenic-related genes, including ALP, RUNX2, Col1a1, and OCN. Mechanically, we found that ASP activated the Wnt/β-catenin pathway. In conclusion, our results suggested that ASP promoted the proliferation and osteogenic differentiation of hDPSCs via the Wnt/β-catenin pathway.

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当归多糖通过激活wnt/β-catenin通路促进人牙髓干细胞增殖和成骨分化

人牙髓干细胞(hDPSCs)能够形成矿化结节。hdpsc的增殖和成骨分化对缓解相关疾病引起的牙齿缺损具有重要意义。当归多糖(ASP)是从当归根中提取的主要生物活性成分。ASP具有多种生物学功能，包括免疫调节、抗肿瘤活性和造血功能。然而，其对hdpsc的可能影响尚不清楚。在本研究中，我们旨在探讨ASP在牙周病中的作用。我们发现，ASP促进了hDPSCs的增殖和成骨分化。我们进一步发现，它促进了成骨相关基因的表达，包括ALP、RUNX2、Col1a1和OCN。机械地，我们发现ASP激活了Wnt/β-catenin通路。综上所述，我们的研究结果表明，ASP通过Wnt/β-catenin途径促进了hDPSCs的增殖和成骨分化。

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来源期刊

Quality Assurance and Safety of Crops & Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

4.60

自引率

7.50%

发文量

审稿时长

1 months

期刊介绍： ''Quality Assurance and Safety of Crops & Foods'' is an international peer-reviewed journal publishing research and review papers associated with the quality and safety of food and food sources including cereals, grains, oilseeds, fruits, root crops and animal sources. It targets both primary materials and their conversion to human foods. There is a strong focus on the development and application of new analytical tools and their potential for quality assessment, assurance, control and safety. The scope includes issues of risk assessment, traceability, authenticity, food security and socio-economic impacts. Manuscripts presenting novel data and information that are likely to significantly contribute to scientific knowledge in areas of food quality and safety will be considered. ''Quality Assurance and Safety of Crops & Foods'' provides a forum for all those working in the specialist field of food quality and safety to report on the progress and outcomes of their research.