Chitosan-calcium carbonate scaffold with high mineral content and hierarchical structure for bone regeneration

Q1 Engineering Smart Materials in Medicine Pub Date : 2023-01-01 DOI:10.1016/j.smaim.2023.04.004
Xiaoyang Liu, Zhengke Wang
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引用次数: 2

Abstract

Bone regeneration scaffolds loaded with osteoblast-related cells or cytokines exhibit outstanding therapeutic potential during large-scale bone defect repair. However, limited sources of cells, opportune choosing of growth factors and their concentration, as well as immunological rejection, seriously hinder its clinical application. Developing a scaffold that can effectively recruit MSCs in situ and achieve endogenous bone regeneration is a viable strategy. Herein, we report a chitosan-calcium carbonate scaffold with high mineral content and centripetal pore arrangement using a simple in situ mineralization method. In vivo results first time demonstrate that the scaffold with high calcium carbonate content can effectively recruit MSCs near the defect area, induce their osteogenic differentiation, and ultimately accelerate the process of bone regeneration. Considering the accessible preparation and excellent osteogenicity, the chitosan-calcium carbonate scaffold possesses high potential for the therapeutics of massive bone defects.

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高矿物质、分级结构的壳聚糖-碳酸钙骨再生支架
载成骨细胞相关细胞或细胞因子的骨再生支架在大规模骨缺损修复中表现出突出的治疗潜力。然而,细胞来源有限、生长因子及其浓度选择不当、免疫排斥等因素严重阻碍了其临床应用。开发一种能够原位有效募集MSCs并实现内源性骨再生的支架是一种可行的策略。在此,我们报告了一个壳聚糖-碳酸钙支架具有高矿物质含量和向心孔排列使用简单的原位矿化方法。体内实验结果首次证明,高碳酸钙含量的支架能够有效募集缺损区域附近的MSCs,诱导其成骨分化,最终加速骨再生过程。壳聚糖-碳酸钙支架材料制备方便,成骨性好,在治疗大面积骨缺损方面具有很大的应用潜力。
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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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