Molecular Perceptions on Tumour Metastasis in Oral Squamous Cell Carcinoma (OSCC): Potential for Therapeutic Interventions

Abstract

Oral cancer is a foremost health concern and India accounts for about one third of its universal burden. About 80% of oral cancers in India are oral squamous cell carcinoma. They are associated with alarming fatality rates and the inability to prevent tumour metastasis being a prime reason. Considerate knowledge on the molecular events of tumour progression may give insight on developing rationale for the targeted prevention. This review intends to highlight the critical role of primary tumour and the tumour microenvironment in initiating metastasis and the mechanisms underlying the establishment of metastatic foci. Better understanding of these processes may help in targeting more research into the control of metastasis and thus disease control.