Comparison of performance of composite biomarkers of inflammatory response in determining the prognosis of breast cancer patients

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pteridines Pub Date : 2017-12-20 DOI:10.1515/pterid-2017-0005

B. Melichar, D. Vitásková, M. Bartoušková, L. Javorská, L. Kujovská Krčmová, Eliška Pešková, R. Hyšpler, D. Solichová, K. Hruzová, H. Študentová

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引用次数: 3

Abstract

Abstract In the present study, we determined complex indices of inflammatory activity and compared the performance of these indices as prognostic biomarkers in a cohort of breast cancer patients. All proposed composite biomarkers could be evaluated in 418 out of 474 patients in the cohort with complete data on peripheral blood cell count, urinary neopterin, albumin and C-reactive protein. Neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio, systemic inflammatory index, Glasgow prognostic index, modified Glasgow prognostic index, prognostic nutritional index and C-reactive protein/albumin ratio were calculated and further complex indices were proposed. Although a number of the investigated indices were significantly associated with survival in the univariate analysis, only age and stage, but none of the laboratory biomarkers or composite biomarkers, were significant predictors of survival in the whole group in the multivariate analysis. In patients evaluated before the start of the treatment, age, stage and urinary neopterin were significant predictors of survival. These results underscore the importance of neopterin as a prognostic biomarker in breast cancer.

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炎症反应复合生物标志物在判断癌症患者预后中的作用比较

摘要在本研究中，我们确定了炎症活性的复杂指标，并比较了这些指标在癌症患者队列中作为预后生物标志物的表现。所有提出的复合生物标志物都可以在队列中474名患者中的418名患者中进行评估，这些患者具有外周血细胞计数、尿新蝶呤、白蛋白和C反应蛋白的完整数据。计算中性粒细胞与淋巴细胞的比率、淋巴细胞与单核细胞的比率、血小板与淋巴细胞的比例、全身炎症指数、格拉斯哥预后指数、改良格拉斯哥预后指数和预后营养指数以及C反应蛋白/白蛋白比率，并提出进一步的复杂指数。尽管在单变量分析中，许多研究指标与生存率显著相关，但在多变量分析中只有年龄和阶段是整个组生存率的重要预测因素，而没有实验室生物标志物或复合生物标志物。在开始治疗前评估的患者中，年龄、分期和尿新蝶呤是生存率的重要预测因素。这些结果强调了新蝶呤作为癌症预后生物标志物的重要性。

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.