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Effect of NB-UVB therapy on IL-6 and neopterin levels in patients with psoriasis NB-UVB治疗对银屑病患者IL-6和新蝶呤水平的影响
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2023-01-01 DOI: 10.1515/pteridines-2022-0048
E. Şahin, Sonia Sanajou, G. Girgin, T. Akan, T. Baydar
Abstract Background Psoriasis is a chronic and non-transient disease with increased epidermal proliferation in the skin. Dysregulation of the immune system is an important factor in this pathology. Inflammation markers, pro-inflammatory cytokines, and immune cells are reported to be changed in psoriasis. Study design In the current cohort study, the possible changes in interleukin-6 (IL-6), neopterin levels, and kynurenine (Kyn) pathway in 42 psoriasis patients compared to 30 controls, and their change with narrow-band (NB) UVB treatment were investigated. Methodology IL-6 and serum neopterin levels were analyzed with ELISA kits. HPLC analyses were performed to detect urinary neopterin, serum Kyn, and tryptophan (Trp) levels. Results IL-6 levels were lower, while Kyn levels and the Kyn-to-Trp ratio were higher in psoriasis patients compared to control subjects (p < 0.01, all). Conclusion Narrow-band ultraviolet B (NB-UVB) treatment decreased Psoriasis Area and Severity Index (PASI) scores and increased urinary neopterin levels of the patients (both, p < 0.01). Serum neopterin was correlated with Kyn and Kyn/Trp levels before and after NB-UVB treatment (p < 0.05, all). These findings point out that the measured parameters might be considered to support the PASI score in both diagnosis and prognosis of psoriasis rather than evaluating the severity of the disease.
背景银屑病是一种慢性非短暂性疾病,伴有皮肤表皮增生增加。免疫系统失调是这种病理的一个重要因素。据报道,炎症标志物、促炎细胞因子和免疫细胞在牛皮癣中发生了变化。在本队列研究中,研究了42例银屑病患者与30例对照组相比,白细胞介素-6 (IL-6)、新蝶呤(neopterin)水平和犬尿氨酸(Kyn)途径可能发生的变化,以及它们在窄带(NB) UVB治疗后的变化。方法采用ELISA试剂盒分析血清IL-6和新蝶呤水平。采用高效液相色谱法检测尿中新蝶呤、血清Kyn和色氨酸水平。结果银屑病患者IL-6水平低于对照组,Kyn水平及Kyn /色氨酸比值高于对照组(p均< 0.01)。结论窄带紫外线B (NB-UVB)治疗可降低患者银屑病面积及严重程度指数(PASI)评分,提高尿新蝶呤水平(p < 0.01)。NB-UVB治疗前后血清neopterin与Kyn、Kyn/色氨酸水平相关(p < 0.05)。这些发现表明,测量参数可能被认为在银屑病的诊断和预后方面支持PASI评分,而不是评估疾病的严重程度。
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引用次数: 1
The advent of phyllobilins as bioactive phytochemicals – natural compounds derived from chlorophyll in medicinal plants and food with immunomodulatory activities 叶根磷脂作为生物活性植物化学物质的出现-从药用植物和食品中提取的具有免疫调节活性的天然化合物
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2023-01-01 DOI: 10.1515/pteridines-2022-0047
A. Vollmar, Simone Moser
Abstract The degradation of the green plant pigment chlorophyll has fascinated chemists and biologists alike over the last few decades. Bioactivities of the compounds formed in this biochemical degradation pathway, however, have only come to light recently. These natural compounds that are formed from chlorophyll during plant senescence are now called phyllobilins. In this review, we shortly discuss chlorophyll degradation and outline the so-far known bioactivities of selected phyllobilins (phylloleucobilin, dioxobilin-type phylloleucobilin, and phylloxanthobilin), and we also highlight the recently discovered immunomodulatory effects of a yellow phylloxanthobilin.
摘要在过去的几十年里,绿色植物色素叶绿素的降解一直吸引着化学家和生物学家。然而,在这种生物化学降解途径中形成的化合物的生物活性最近才被发现。这些在植物衰老过程中由叶绿素形成的天然化合物现在被称为叶胆素。在这篇综述中,我们简要讨论了叶绿素降解,并概述了迄今为止已知的所选叶胆素的生物活性(叶胆素、二氧杂环丁烷型叶胆素和叶黄素),我们还强调了最近发现的黄色叶黄素的免疫调节作用。
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引用次数: 1
Association between plasma total homocysteine (tHcy) and strokes: A meta-analysis 血浆总同型半胱氨酸(tHcy)与中风的相关性:一项荟萃分析
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2022-01-01 DOI: 10.1515/pteridines-2022-0044
Hang Li, Lingfeng Shu, Qinghai Dai, Tao-Yu Wu
Abstract Objective Inconsistent findings have been reported regarding the association between elevated plasma total homocysteine (tHcy) and the risk of different types of strokes. We conducted this meta-analysis to identify the association between tHcy and different kinds of strokes or recurrences of strokes, and provide evidence for preventing. Methods Relevant studies published before May 1, 2022 in databases such as PubMed, EMBASE, the Cochrane Library, CNKI, and Wanfang were retrieved. Two researchers independently searched and extracted the data, and used Stata 16.0 statistical software for analysis. Results were presented as the odds risk (OR) and the corresponding 95% confidence intervals (CI). Results In total, 24 articles were included, involving 51,426 subjects, of which 4,983 had stroke events during follow-up. Relative to lower tHcy, higher tHcy were associated with increased stroke (OR = 1.95, 95% CI: 1.59–2.37), ischemic stroke (OR = 1.71, 95% CI: 1.39–2.11), hemorrhagic stroke (OR = 1.99, 95% CI: 1.03–3.84), and recurrent stroke (OR = 1.25, 95% CI: 1.12–1.39), respectively. Conclusions This study shows that elevated tHcy increases the risk of stroke, including ischemic stroke and hemorrhagic stroke, and is closely related to the recurrence of stroke. It is recommended to pay attention to the detection of tHcy in the management of stroke patients in the future, and take effective measures to prevent and delay the progression of stroke.
摘要目的关于血浆总同型半胱氨酸(tHcy)升高与不同类型中风风险之间的关系,已有不一致的研究报告。我们进行了这项荟萃分析,以确定tHcy与不同类型的中风或中风复发之间的关系,并为预防提供证据。方法检索PubMed、EMBASE、Cochrane Library、CNKI、万方等数据库2022年5月1日前发表的相关研究。两名研究人员独立搜索并提取数据,并使用Stata 16.0统计软件进行分析。结果以比值风险(OR)和相应的95%置信区间(CI)表示。结果共纳入24篇文章,涉及51426名受试者,其中4983人在随访中发生了脑卒中事件。与较低tHcy相比,较高tHcy分别与卒中增加(OR=1.95,95%CI:1.59-2.37)、缺血性卒中(OR=1.71,95%CI:1.39-2.11)、出血性卒中(OR=1.99,95%CI:1.03-3.84)和复发性卒中(OR=1.25,95%CI:1.12-1.39)有关。结论tHcy升高会增加脑卒中的风险,包括缺血性脑卒中和出血性脑卒中,并与脑卒中的复发密切相关。建议今后在脑卒中患者的管理中注意tHcy的检测,采取有效措施预防和延缓脑卒中的进展。
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引用次数: 0
Immunopterin: A prospective therapy and preventative to fight COVID-19? 免疫蝶呤:对抗COVID-19的前瞻性治疗和预防措施?
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2022-01-01 DOI: 10.1515/pteridines-2022-0038
Phillip B. B. Moheno, D. Fuchs
Abstract Background The authors explore the therapeutic and prophylactic efficacies of Immunopterin (calcium pterin-6-carboxylate chelate) against coronavirus colds and as a therapy against COVID-19. Methods To determine Immunopterin’s therapeutic efficacy against colds and flus, a 5-year observational study was conducted with 34 subjects who took Immunopterin when feeling symptoms of a cold or flu. The mean sample cold recovery time was compared to the US population mean. A review of the Moheno (2014) 2-year observational study was conducted to evaluate the prophylactic efficacy of Immunopterin against colds. Early COVID-19 case studies, treated with Immunopterin, were collected to explore Immunopterin’s efficacy as a therapeutic and prophylactic against COVID19 disease. Results The mean cold recovery time for the therapeutic sample in the cold/flu observational study was 30 h compared to the US population mean of 168 h (N = 34; p < 0.001). Subjects taking prophylactic Immunopterin reported 0% incidences of colds and flus (N = 31). Immunopterin successfully treated four confirmed COVID-19 subjects. A fifth clinical nurse case study demonstrates COVID-19 prevention. Conclusions The therapeutic and prophylactic efficacies of Immunopterin against coronavirus colds, along with reported cross-reactivity between coronavirus colds and SARS-CoV-2 strongly suggest Immunopterin can act as a therapy and preventative against COVID- 19 infection associated disease.
摘要背景探讨免疫蝶呤(6-羧酸螯合蝶呤钙)对冠状病毒感冒和COVID-19的治疗和预防作用。方法为确定免疫蝶呤治疗感冒和流感的疗效,对34名出现感冒或流感症状时服用免疫蝶呤的受试者进行了为期5年的观察研究。将平均样本冷恢复时间与美国人口平均值进行比较。对Moheno(2014)的2年观察性研究进行了回顾,以评估免疫蝶呤对感冒的预防效果。收集使用免疫蝶呤治疗的早期COVID-19病例研究,探讨免疫蝶呤作为治疗和预防COVID-19疾病的疗效。结果:在感冒/流感观察性研究中,治疗样本的平均感冒恢复时间为30小时,而美国人群的平均感冒恢复时间为168小时(N = 34;P < 0.001)。服用预防性免疫蝶呤的受试者报告感冒和流感的发生率为0% (N = 31)。免疫蝶呤成功治疗了4例新冠肺炎确诊患者。第五个临床护士案例研究展示了COVID-19的预防。结论免疫蝶呤对冠状病毒感冒的治疗和预防效果,以及已报道的冠状病毒感冒与SARS-CoV-2之间的交叉反应性,强烈提示免疫蝶呤可以作为一种治疗和预防COVID- 19感染相关疾病的药物。
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引用次数: 0
Mercury exposure, neopterin profile, and tryptophan degradation in dental technicians 牙科技师的汞暴露、新蝶呤谱和色氨酸降解
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2022-01-01 DOI: 10.1515/pteridines-2022-0040
G. Girgin, Saziye Sezin Palabiyik-Yücelik, H. Sipahi, Bilge Kilicarslan, S. Ünüvar, E. Tutkun, Ö. Yılmaz, T. Baydar
Abstract Amalgam has been widely used as a restorative dental material for over 150 years. Most standard dental amalgam formulations contain approximately 50% elemental mercury in a mixture of copper, tin, silver, and zinc. Mercury is a highly volatile metal, which can easily vaporize to a colorless and odorless gas. It has been demonstrated that mercury is released from dental amalgam, which is increased by chewing, eating, brushing, and drinking hot liquids. Besides this, amalgam is the main occupational exposure source of mercury for dental workers. It is known that mercury exposure causes immune modulation in humans. In this study, it was aimed to evaluate the changes in neopterin levels and tryptophan (Trp) degradation in dental technicians. It was observed that low levels of occupational mercury exposure resulted in decreased neopterin, kynurenine (Kyn), and Kyn/Trp levels. Moreover, mercury and neopterin levels had a significant positive correlation in workers. The lower neopterin levels and Kyn/Trp in dental technicians compared to an unexposed group indicates a possible immune suppression with low level of occupational mercury exposure during amalgam preparation. The relationship between urinary mercury levels as an indicator of occupational mercury exposure and neopterin reminded an effect on T-cell-mediated immune response.
摘要汞合金作为一种牙科修复材料已经被广泛使用了150多年 年。大多数标准的牙科汞合金配方在铜、锡、银和锌的混合物中含有大约50%的单质汞。汞是一种高度挥发性的金属,很容易蒸发成无色无味的气体。已经证明,汞是从牙科汞合金中释放出来的,通过咀嚼、进食、刷牙和饮用热液体会增加汞的含量。除此之外,汞合金是牙科工作者汞的主要职业暴露源。众所周知,汞暴露会导致人体免疫调节。在本研究中,旨在评估牙科技术人员新蝶呤水平和色氨酸(Trp)降解的变化。据观察,低水平的职业汞暴露会导致新蝶呤、犬尿氨酸(Kyn)和Kyn/Trp水平下降。此外,工人体内汞和新蝶呤水平呈显著正相关。与未暴露组相比,牙科技师的新蝶呤水平和Kyn/Trp较低,这表明在汞合金制备过程中,职业汞暴露水平较低,可能存在免疫抑制。作为职业汞暴露指标的尿汞水平与新蝶呤之间的关系提醒人们注意对T细胞介导的免疫反应的影响。
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引用次数: 0
Serum homocysteine level was elevated in ulcerative colitis and can be applied as diagnostic biomarker 血清同型半胱氨酸水平在溃疡性结肠炎中升高,可作为诊断性生物标志物
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2022-01-01 DOI: 10.1515/pteridines-2022-0046
Xiaoping Zhang, Shanshan Wang, Hongmin Wang, Jun-min Wu, Q. Tan
Abstract Objective To investigate the correlation between serum level of homocysteine (Hcy) and ulcerative colitis (UC) and evaluate its diagnostic performance by pooling the open published data. Methods The case–control or cohort studies relevant to serum level of Hcy and UC, published in Pubmed, Medline, EMBASE, China Wanfang and CNKI databases, were systematically screened by using the text word of “homocysteine,” “hcy,” “UC,” “inflammatory bowel disease.” The standard mean difference (SMD) was pooled through random effect model. The diagnostic sensitivity, specificity and area under the receiver operating characteristic (AUC) curve of serum Hcy for UC were also calculated. Results Eighteen relevant case–control studies were identified by electronic searching the related databases. The pooled results indicated that the serum levels of Hcy were statical different between UC and healthy controls with SMD = 0.95 (95% CI: 0.87–1.04). The serum levels of Hcy were 14.30 ± 3.08 (range: 10.10–21.73) and 10.09 ± 1.57 (range: 6.80–12.47) μmol/L for UC and healthy controls, respectively, of the included 18 studies. Using serum Hcy as biomarker for UC identification, the diagnostic sensitivity, specificity and AUC were 94.44% (95% CI: 72.71–99.86%), 72.22% (46.52–90.31%) and 0.88 (95% CI: 0.77–0.99, P < 0.05), respectively. Significant publication bias was identified in the present work. Conclusion Based on the present publications, serum Hcy was elevated in UC cases and can be applied as serological marker for UC diagnosis. However, due to significant publication bias, the diagnostic performance should be further validated by well-designed prospective diagnostic studies.
摘要目的探讨血清同型半胱氨酸(Hcy)水平与溃疡性结肠炎(UC)的相关性,并通过汇集公开发表的数据来评估其诊断性能。方法采用“同型半胱氨酸”、“Hcy”、“UC”、“炎症性肠病”等文本词,系统筛选Pubmed、Medline、EMBASE、中国万方和CNKI数据库中发表的与Hcy和UC血清水平相关的病例对照或队列研究。还计算了血清Hcy对UC的诊断敏感性、特异性和受试者工作特性曲线下面积(AUC)。结果通过电子检索相关数据库,确定了18项相关病例对照研究。合并结果表明,UC和健康对照组的血清Hcy水平存在统计学差异,SMD=0.95(95%CI:0.87–1.04)。Hcy水平分别为14.30±3.08(范围:10.10–21.73)和10.09±1.57(范围:6.80–12.47) μmol/L,分别用于UC和健康对照。使用血清Hcy作为UC识别的生物标志物,诊断灵敏度、特异性和AUC分别为94.44%(95%CI:72.71–99.86%)、72.22%(46.52–90.31%)和0.88(95%CI:0.77–0.99,P<0.05)。在目前的工作中发现了重大的出版偏见。结论UC患者血清Hcy升高,可作为UC诊断的血清学标志物。然而,由于显著的发表偏倚,诊断性能应通过精心设计的前瞻性诊断研究进一步验证。
{"title":"Serum homocysteine level was elevated in ulcerative colitis and can be applied as diagnostic biomarker","authors":"Xiaoping Zhang, Shanshan Wang, Hongmin Wang, Jun-min Wu, Q. Tan","doi":"10.1515/pteridines-2022-0046","DOIUrl":"https://doi.org/10.1515/pteridines-2022-0046","url":null,"abstract":"Abstract Objective To investigate the correlation between serum level of homocysteine (Hcy) and ulcerative colitis (UC) and evaluate its diagnostic performance by pooling the open published data. Methods The case–control or cohort studies relevant to serum level of Hcy and UC, published in Pubmed, Medline, EMBASE, China Wanfang and CNKI databases, were systematically screened by using the text word of “homocysteine,” “hcy,” “UC,” “inflammatory bowel disease.” The standard mean difference (SMD) was pooled through random effect model. The diagnostic sensitivity, specificity and area under the receiver operating characteristic (AUC) curve of serum Hcy for UC were also calculated. Results Eighteen relevant case–control studies were identified by electronic searching the related databases. The pooled results indicated that the serum levels of Hcy were statical different between UC and healthy controls with SMD = 0.95 (95% CI: 0.87–1.04). The serum levels of Hcy were 14.30 ± 3.08 (range: 10.10–21.73) and 10.09 ± 1.57 (range: 6.80–12.47) μmol/L for UC and healthy controls, respectively, of the included 18 studies. Using serum Hcy as biomarker for UC identification, the diagnostic sensitivity, specificity and AUC were 94.44% (95% CI: 72.71–99.86%), 72.22% (46.52–90.31%) and 0.88 (95% CI: 0.77–0.99, P < 0.05), respectively. Significant publication bias was identified in the present work. Conclusion Based on the present publications, serum Hcy was elevated in UC cases and can be applied as serological marker for UC diagnosis. However, due to significant publication bias, the diagnostic performance should be further validated by well-designed prospective diagnostic studies.","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"33 1","pages":"87 - 93"},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41860546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MTHFR C667T polymorphism and diabetic nephropathy susceptibility in patients with type 2 diabetes mellitus: An updated meta-analysis MTHFR C667T多态性与2型糖尿病患者糖尿病肾病易感性的最新荟萃分析
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2022-01-01 DOI: 10.1515/pteridines-2022-0039
Xiao-dong Wang, Lejian Lan
Abstract Background Numerous studies indicated that there exists a relationship between methylenetetrahydrofolate reductase (MTHFR) C667T polymorphism and diabetic nephropathy (DN) susceptibility; nonetheless, available proof reported from individual studies has not been consistent, so we performed an updated meta-analysis to evaluate the relationship between MTHFR C667T variant and DN. Materials and methods Relevant studies published before February 2022 were searched from the electronic databases PubMed, Embase, Scopus, Chinese Biology Medicine and the Chinese National Knowledge Infrastructure. The strength of the association was examined by odds ratio (OR) with 95% confidence interval (CI). Results The findings illustrated that there was a significant relationship between the polymorphism of C677T and DN compared with that to DM controls in allele (OR = 1.59, 95% CI = 1.39–1.82), dominant (OR = 1.76, 95% CI = 1.47–2.11) and recessive (OR = 1.85, 95% CI = 1.56–2.20) models in all populations. Moreover, as compared with the healthy controls, a significant relationship between C677T and DN was found in three genetic comparison models (allele: OR = 1.81, 95% CI = 1.43–2.29; dominant: OR = 2.09, 95% CI = 1.54–2.85; recessive: OR = 2.02, 95% CI = 1.51–2.70). Furthermore, stratifying data by race, diabetes duration and whether in Hardy–Weinberg equilibrium revealed substantially augmented vulnerability to DN in all subgroups. Conclusion The current meta-analysis highlighted conclusive results for the robust association between C677T polymorphisms and DN susceptibility.
摘要背景大量研究表明,亚甲基四氢叶酸还原酶(MTHFR)C667T多态性与糖尿病肾病(DN)易感性之间存在相关性;尽管如此,个别研究报告的可用证据并不一致,因此我们进行了一项更新的荟萃分析,以评估MTHFR C667T变体与DN之间的关系。材料和方法从电子数据库PubMed、Embase、Scopus、中国生物医药和中国国家知识基础设施中检索2022年2月之前发表的相关研究。相关性的强度通过95%置信区间(CI)的比值比(OR)进行检验。结果在等位基因(OR=1.59,95%CI=1.39–1.82)、显性(OR=1.76,95%CI=1.47–2.11)和隐性(OR=1.85,95%CI=1.56–2.20)模型中,C677T和DN的多态性与DM对照组相比存在显著关系。此外,与健康对照组相比,在三个遗传比较模型中发现C677T与DN之间存在显著关系(等位基因:OR=1.81,95%CI=1.43–2.29;显性:OR=2.09,95%CI=1.54–2.85;隐性:OR=2.02,95%CI=1.51–2.70)。此外,按种族对数据进行分层,糖尿病持续时间和是否处于Hardy-Weinberg平衡显示,所有亚组对DN的易感性显著增加。结论目前的荟萃分析强调了C677T多态性与DN易感性之间强有力关联的结论性结果。
{"title":"MTHFR C667T polymorphism and diabetic nephropathy susceptibility in patients with type 2 diabetes mellitus: An updated meta-analysis","authors":"Xiao-dong Wang, Lejian Lan","doi":"10.1515/pteridines-2022-0039","DOIUrl":"https://doi.org/10.1515/pteridines-2022-0039","url":null,"abstract":"Abstract Background Numerous studies indicated that there exists a relationship between methylenetetrahydrofolate reductase (MTHFR) C667T polymorphism and diabetic nephropathy (DN) susceptibility; nonetheless, available proof reported from individual studies has not been consistent, so we performed an updated meta-analysis to evaluate the relationship between MTHFR C667T variant and DN. Materials and methods Relevant studies published before February 2022 were searched from the electronic databases PubMed, Embase, Scopus, Chinese Biology Medicine and the Chinese National Knowledge Infrastructure. The strength of the association was examined by odds ratio (OR) with 95% confidence interval (CI). Results The findings illustrated that there was a significant relationship between the polymorphism of C677T and DN compared with that to DM controls in allele (OR = 1.59, 95% CI = 1.39–1.82), dominant (OR = 1.76, 95% CI = 1.47–2.11) and recessive (OR = 1.85, 95% CI = 1.56–2.20) models in all populations. Moreover, as compared with the healthy controls, a significant relationship between C677T and DN was found in three genetic comparison models (allele: OR = 1.81, 95% CI = 1.43–2.29; dominant: OR = 2.09, 95% CI = 1.54–2.85; recessive: OR = 2.02, 95% CI = 1.51–2.70). Furthermore, stratifying data by race, diabetes duration and whether in Hardy–Weinberg equilibrium revealed substantially augmented vulnerability to DN in all subgroups. Conclusion The current meta-analysis highlighted conclusive results for the robust association between C677T polymorphisms and DN susceptibility.","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"33 1","pages":"21 - 31"},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44669530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Folate receptor genes were up-regulated in epithelial ovarian cancer and partly associated with patients’ prognosis 叶酸受体基因在上皮性癌症中上调,部分与患者预后相关
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2022-01-01 DOI: 10.1515/pteridines-2022-0043
Juanli Yang, Zhengyu Tang, Yan Ma, Weilei Dong, Gui-fang Luo, Furong Yu, Feng Jiang, Xiaolan Wang, W. Liao
Abstract Objective The present work aimed to investigate folate receptor (FOLR1, FOLR2, FOLR3) expression, functional enrichment, signaling pathway and prognosis in ovarian cancer patients by integrated bioinformatics analysis. Methods Folate receptor (FOLR1, FOLR2, and FOLR3) mRNA expression level between epithelial ovarian cancer and corresponding normal ovarian tissue of cancer patients was compared through the TCGA database by GEPIA online analysis tool. The protein–protein interaction (PPI) network of FOLR1, FOLR2, FOLR3, and related genes were constructed through the STRING database. GO and KEGG enrichment of FOLR1, FOLR2, FOLR3, and relevant genes were analyzed. Overall survival (OS) and progression-free survival (PFS) between FOLR1, FOLR2, and FOLR3 mRNA high and low expression epithelial ovarian cancer patients were compared by log-rank test. Results FOLR and FOLR3 mRNA expression in epithelial ovarian cancer tissue were significantly higher than that of corresponding normal ovarian tissue of cancer patients (P < 0.05) The PPI network showed 53 nodes and 298 edges with the average node degree of 11.2. The local clustering coefficient was 0.744, which indicated that the protein–protein enrichment was statistically significant (P < 1.0 × 10−16). Folate receptor (FOLR1, FOLR2, and FOLR3) and relevant genes were mainly enriched in folic acid transport, methotrexate transmembrane transporter activity, antifolate resistance for biological process, molecular function, and KEGG pathway, respectively. The PFS of FOLR1 and FOLR3 high expression epithelial ovarian cancer patients was significantly lower compared to low-expression subjects with statistical significance [hazard ratio (HRFOLR1) = 1.26, 95% confidence interval (CI): 1.09–1.45, P < 0.05, HRFOLR3 = 1.22, 95% CI: 1.06–1.40, P < 0.05]. However, the OS was not statistically different between FOLR1, FOLR2, and FOLR3 low and high expression groups. Conclusion Folate receptor (FOLR1, FOLR2, and FOLR3) genes were up-regulated in epithelial ovarian cancer and partly associated with patient’s poor prognosis.
摘要目的通过生物信息学综合分析,探讨卵巢癌症患者叶酸受体(FOLR1、FOLR2、FOLR3)的表达、功能富集、信号传导途径及预后。方法采用GEPIA在线分析工具,通过TCGA数据库,比较癌症患者卵巢上皮癌症与相应正常卵巢组织中叶酸受体(FOLR1、FOLR2和FOLR3)mRNA的表达水平。通过STRING数据库构建了FOLR1、FOLR2、FOLR3和相关基因的蛋白质-蛋白质相互作用(PPI)网络。分析了GO和KEGG对FOLR1、FOLR2、FOLR3和相关基因的富集。通过log-rank检验比较FOLR1、FOLR2和FOLR3mRNA高表达和低表达上皮性癌症患者的总生存率(OS)和无进展生存率(PFS)。结果卵巢上皮癌症组织中FOLR和FOLR3mRNA的表达显著高于癌症患者相应的正常卵巢组织(P<0.05)。PPI网络显示53个节点和298个边缘,平均节点度为11.2。局部聚类系数为0.744,表明蛋白质-蛋白质富集具有统计学意义(P<1.0×10−16)。叶酸受体(FOLR1、FOLR2和FOLR3)和相关基因分别主要富集在叶酸转运、甲氨蝶呤跨膜转运蛋白活性、生物过程的抗叶酸耐药性、分子功能和KEGG途径中。与低表达受试者相比,FOLR1和FOLR3高表达上皮性卵巢癌症患者的PFS显著降低,具有统计学意义[风险比(HRFOLR1)=1.26,95%置信区间(CI):1.09-1.45,P<0.05,HRFOLR3=1.22,95%CI:1.06–1.40,P<0.05],以及FOLR3低表达组和高表达组。结论叶酸受体(FOLR1、FOLR2和FOLR3)基因在上皮性卵巢癌症中表达上调,部分与患者预后不良有关。
{"title":"Folate receptor genes were up-regulated in epithelial ovarian cancer and partly associated with patients’ prognosis","authors":"Juanli Yang, Zhengyu Tang, Yan Ma, Weilei Dong, Gui-fang Luo, Furong Yu, Feng Jiang, Xiaolan Wang, W. Liao","doi":"10.1515/pteridines-2022-0043","DOIUrl":"https://doi.org/10.1515/pteridines-2022-0043","url":null,"abstract":"Abstract Objective The present work aimed to investigate folate receptor (FOLR1, FOLR2, FOLR3) expression, functional enrichment, signaling pathway and prognosis in ovarian cancer patients by integrated bioinformatics analysis. Methods Folate receptor (FOLR1, FOLR2, and FOLR3) mRNA expression level between epithelial ovarian cancer and corresponding normal ovarian tissue of cancer patients was compared through the TCGA database by GEPIA online analysis tool. The protein–protein interaction (PPI) network of FOLR1, FOLR2, FOLR3, and related genes were constructed through the STRING database. GO and KEGG enrichment of FOLR1, FOLR2, FOLR3, and relevant genes were analyzed. Overall survival (OS) and progression-free survival (PFS) between FOLR1, FOLR2, and FOLR3 mRNA high and low expression epithelial ovarian cancer patients were compared by log-rank test. Results FOLR and FOLR3 mRNA expression in epithelial ovarian cancer tissue were significantly higher than that of corresponding normal ovarian tissue of cancer patients (P < 0.05) The PPI network showed 53 nodes and 298 edges with the average node degree of 11.2. The local clustering coefficient was 0.744, which indicated that the protein–protein enrichment was statistically significant (P < 1.0 × 10−16). Folate receptor (FOLR1, FOLR2, and FOLR3) and relevant genes were mainly enriched in folic acid transport, methotrexate transmembrane transporter activity, antifolate resistance for biological process, molecular function, and KEGG pathway, respectively. The PFS of FOLR1 and FOLR3 high expression epithelial ovarian cancer patients was significantly lower compared to low-expression subjects with statistical significance [hazard ratio (HRFOLR1) = 1.26, 95% confidence interval (CI): 1.09–1.45, P < 0.05, HRFOLR3 = 1.22, 95% CI: 1.06–1.40, P < 0.05]. However, the OS was not statistically different between FOLR1, FOLR2, and FOLR3 low and high expression groups. Conclusion Folate receptor (FOLR1, FOLR2, and FOLR3) genes were up-regulated in epithelial ovarian cancer and partly associated with patient’s poor prognosis.","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"33 1","pages":"69 - 77"},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46822509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epithelial nitric oxide synthases (eNOS) 894 G < T polymorphism and diabetic nephropathy susceptibility: A meta-analysis 上皮一氧化氮合酶(eNOS)894 G<T多态性与糖尿病肾病易感性的荟萃分析
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2022-01-01 DOI: 10.1515/pteridines-2022-0042
Hui Li, Guiqin Shu, Huihui Gao
Abstract Objective To investigate the epithelial nitric oxide synthases (eNOS) 894 G < T polymorphism and diabetic nephropathy (DN) susceptibility by pooling the open published data. Methods Studies relevant to eNOS 894 G < T polymorphism and DN susceptibility published in PubMed, EMBASE, Medline, CNKI, and Wanfang databases were systematically screened by using the text words of endothelial nitric oxide synthase, eNOS, NOS-3, G894T, rs179983, polymorphism, diabetic nephropathy, and DN. The correlation between eNOS 894 G < T polymorphism and DN susceptibility was demonstrated by odds ratio (OR) and corresponding 95% confidence interval (95% CI). The data were combined through fixed or random effect model according to statistical heterogeneity. The publication bias was assessed by Begg’s funnel plot and Egger’s line regression test. Results Twenty-six case-control studies relevant to eNOS 894 G < T polymorphism and DN susceptibility were identified by electronic searching of the related databases. Type 2 diabetes mellitus (T2MD) patients with T allele had increased susceptibility to DN compared with G allele under homologous gene model (TT vs GG) (OR = 1.40, 95% CI: 1.16–1.69, p = 0.001), dominant gene model (TT + GT) vs GG (OR = 1.61, 95% CI: 1.30–2.00, p = 0.000) and recessive gene model TT vs (GT + GG) (OR = 1.39, 95% CI: 1.16–1.66, p = 0.000). Publication bias was not statistically significant for homologous and recessive gene model. Conclusion Based on the present evidence, DN risk was increased in T2MD cases with T allele compared to G allele.
摘要目的通过汇集公开发表的数据,探讨上皮一氧化氮合酶(eNOS)894 G
{"title":"Epithelial nitric oxide synthases (eNOS) 894 G < T polymorphism and diabetic nephropathy susceptibility: A meta-analysis","authors":"Hui Li, Guiqin Shu, Huihui Gao","doi":"10.1515/pteridines-2022-0042","DOIUrl":"https://doi.org/10.1515/pteridines-2022-0042","url":null,"abstract":"Abstract Objective To investigate the epithelial nitric oxide synthases (eNOS) 894 G < T polymorphism and diabetic nephropathy (DN) susceptibility by pooling the open published data. Methods Studies relevant to eNOS 894 G < T polymorphism and DN susceptibility published in PubMed, EMBASE, Medline, CNKI, and Wanfang databases were systematically screened by using the text words of endothelial nitric oxide synthase, eNOS, NOS-3, G894T, rs179983, polymorphism, diabetic nephropathy, and DN. The correlation between eNOS 894 G < T polymorphism and DN susceptibility was demonstrated by odds ratio (OR) and corresponding 95% confidence interval (95% CI). The data were combined through fixed or random effect model according to statistical heterogeneity. The publication bias was assessed by Begg’s funnel plot and Egger’s line regression test. Results Twenty-six case-control studies relevant to eNOS 894 G < T polymorphism and DN susceptibility were identified by electronic searching of the related databases. Type 2 diabetes mellitus (T2MD) patients with T allele had increased susceptibility to DN compared with G allele under homologous gene model (TT vs GG) (OR = 1.40, 95% CI: 1.16–1.69, p = 0.001), dominant gene model (TT + GT) vs GG (OR = 1.61, 95% CI: 1.30–2.00, p = 0.000) and recessive gene model TT vs (GT + GG) (OR = 1.39, 95% CI: 1.16–1.66, p = 0.000). Publication bias was not statistically significant for homologous and recessive gene model. Conclusion Based on the present evidence, DN risk was increased in T2MD cases with T allele compared to G allele.","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"33 1","pages":"49 - 57"},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46687190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of folic acid, vitamin B12, and B6 supplementation on the risk of cardiovascular and cerebrovascular diseases: An updated meta-analysis of randomized controlled trials 叶酸、维生素B12和B6补充剂对心脑血管疾病风险的影响:一项随机对照试验的最新meta分析
IF 0.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2022-01-01 DOI: 10.1515/pteridines-2022-0041
Man Ye, Xiaohong Chen, Su-Li Mao, Jingzong Zhou, Minfen Liu, Yu Wu
Abstract Background Numerous studies indicated that B vitamin supplementation can reduce cardiovascular risk; nonetheless, available proof reported from individual studies have not been consistent, so we performed an updated meta-analysis of randomized controlled trials (RCTs) to evaluate the relationship between B vitamin supplementation and cardiovascular outcomes. Materials and method Relevant studies published before May 2022 were searched from the electronic databases of PubMed, Embase, the Cochrane Library, Chinese Biology Medicine, and the Chinese National Knowledge Infrastructure. Outcomes included major adverse cardiovascular event (MACE), myocardial infarction (MI), stroke, hospitalization for unstable angina, revascularization, total mortality, and cardiovascular death. The strength of the association was examined by risk ratio (RR) with 95% confidence interval (95% CI). Results A total of 17 RCTs involving 31,085 subjects were included in the meta-analysis. The combined supplementation of B vitamins had no significant effect on MACE based on eight RCTs (RR = 0.98, 95% CI = 0.92–1.04), MI based on 13 RCTs (RR = 1.00, 95% CI = 0.92–1.09), and revascularization based on 12 RCTs (RR = 1.02, 95% CI = 0.95–1.10). Ten studies showed that the combined supplementation of B vitamins reduced the risk of stroke by 12% (RR = 0.88, 95% CI = 0.81–0.97). Eleven studies showed that the combined supplementation of B vitamins had no significant effect on the total mortality (RR = 0.99, 95% CI = 0.94–1.05), and nine studies showed that the combined B vitamins had no significant effect on cardiovascular death (RR = 0.96, 95% CI = 0.88–1.05). Besides, with the extension of follow-up duration and those with a history of cardio-cerebrovascular diseases, supplementation of B vitamins could reduce the risk of stroke. Conclusion The supplementation of folic acid, Vitamin B6, and B12 is associated with a reduction in stroke, but not in total mortality, cardiovascular death, MACE, and MI.
大量研究表明,补充B族维生素可以降低心血管风险;尽管如此,来自个别研究的现有证据并不一致,因此我们对随机对照试验(rct)进行了更新的荟萃分析,以评估补充B族维生素与心血管结局之间的关系。检索PubMed、Embase、Cochrane Library、Chinese Biology Medicine、Chinese National Knowledge Infrastructure电子数据库中2022年5月前发表的相关研究。结果包括主要不良心血管事件(MACE)、心肌梗死(MI)、中风、因不稳定型心绞痛住院、血运重建术、总死亡率和心血管死亡。用95%置信区间(95% CI)的风险比(RR)检验相关性的强度。结果meta分析共纳入17项rct,涉及31,085名受试者。联合补充B族维生素对8项rct (RR = 0.98, 95% CI = 0.92-1.04)、13项rct (RR = 1.00, 95% CI = 0.92-1.09)和12项rct (RR = 1.02, 95% CI = 0.95-1.10)的MACE和血运重建术无显著影响。10项研究表明,联合补充B族维生素可使中风风险降低12% (RR = 0.88, 95% CI = 0.81-0.97)。11项研究表明,联合补充B族维生素对总死亡率无显著影响(RR = 0.99, 95% CI = 0.94-1.05), 9项研究表明,联合补充B族维生素对心血管死亡无显著影响(RR = 0.96, 95% CI = 0.88-1.05)。此外,随着随访时间的延长和有心脑血管病史者,补充B族维生素可降低卒中风险。结论补充叶酸、维生素B6和B12与卒中的减少有关,但与总死亡率、心血管死亡、MACE和心肌梗死无关。
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