{"title":"The involvement of two-pore domain K+ channel TREK-1 in anesthesia","authors":"Shuai Zhao, Yeling Ouyang, Zhiqiang Hu, Xiangdong Chen","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.023","DOIUrl":null,"url":null,"abstract":"TREK-1, a member of two-pore domain K+ channel (K2P) family, has various functions and participates in the regulation of resting membrane potentials. Recent studies indicate that TREK-1 is essential in anesthesia, pain, neuroprotection and depression. Based on domestic and foreign literature related to TREK-1, this review concisely outlines the structure, function, distribution and modulation of TREK-1, and thoroughly presents the advances in those fields above. Furthermore, the role of TREK-1 in general anesthesia, pain, neuroprotection and depression has been elaborated, so as to provide better understanding of the pathological implication of TREK-1 in these fields and facilitate the development of new drugs. \n \n \nKey words: \nTREK-1; Tow-pore domain K+ channel; Anesthesia; Pain perception; Neuroprotection; Depression","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"105-110"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际麻醉学与复苏杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
TREK-1, a member of two-pore domain K+ channel (K2P) family, has various functions and participates in the regulation of resting membrane potentials. Recent studies indicate that TREK-1 is essential in anesthesia, pain, neuroprotection and depression. Based on domestic and foreign literature related to TREK-1, this review concisely outlines the structure, function, distribution and modulation of TREK-1, and thoroughly presents the advances in those fields above. Furthermore, the role of TREK-1 in general anesthesia, pain, neuroprotection and depression has been elaborated, so as to provide better understanding of the pathological implication of TREK-1 in these fields and facilitate the development of new drugs.
Key words:
TREK-1; Tow-pore domain K+ channel; Anesthesia; Pain perception; Neuroprotection; Depression
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