Association of MMP9, MMP13 and MMP20 genes polymorphism with dental caries: A meta-analysis

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pediatric Dental Journal Pub Date : 2022-12-01 DOI:10.1016/j.pdj.2022.09.002

Zahra Molaei , Paria Motahari

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Abstract

Objectives

Genetic factors can be involved in dental caries as the most common chronic oral diseases. The association between polymorphism of MMP9, MMP13 and MMP20 genes with tooth decay has been studied but contradictory outcomes have been indicated. Thus, a meta-analysis was done to get comprehensive outcomes in this path.

Materials and methods

All articles in English by March 2022 were searched with correlated keywords from known database as PubMed, Scopus, Embase and Web of Science, and the articles were selected in several stages based on exclusion and inclusion criteria. Comprehensive meta-analysis software v.2.0 was used for Meta-analysis.

Results

Finally, 11 related articles were selected for meta-analysis. According to the results, MMP9 and MMP20 polymorphisms were not related with increased susceptibility to caries in the studied models, but in the case of MMP13, a significant association was observed between gene polymorphism and caries risk.

Conclusion

The results about MMP13 gene polymorphism showed that guanine G allele and GG genotype have a protective role and decrease the risk of dental caries. It should be noted that, these conclusions could be promoted by studies contain large sample sizes. Finding the genetic factors influencing tooth decay can help increase our current knowledge of caries pathology, predict its occurrence, and target genes at the molecular level to prevent it.

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MMP9、MMP13和MMP20基因多态性与龋病的关联:一项荟萃分析

目的龋病是口腔最常见的慢性疾病，与遗传因素有关。MMP9、MMP13和MMP20基因多态性与蛀牙之间的关系已被研究，但结果却相互矛盾。因此，我们进行了一项荟萃分析，以获得这一途径的综合结果。材料与方法采用相关关键词检索PubMed、Scopus、Embase、Web of Science等数据库中截至2022年3月的所有英文论文，根据排除和纳入标准分阶段筛选。采用综合meta分析软件v.2.0进行meta分析。结果最终选取11篇相关文献进行meta分析。结果显示，在所研究的模型中，MMP9和MMP20基因多态性与龋病易感性增加无关，但在MMP13基因多态性中，基因多态性与龋病风险显著相关。结论MMP13基因多态性分析结果表明，鸟嘌呤G等位基因和GG基因型对龋病有保护作用，可降低龋病发生风险。值得注意的是，这些结论可以通过包含大样本量的研究来促进。发现影响蛀牙的遗传因素可以帮助我们增加对龋齿病理的现有知识，预测其发生，并在分子水平上靶向基因来预防龋齿。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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