Pub Date : 2025-03-19DOI: 10.1016/j.pdj.2025.100347
Bareera Iram, Akash Bhatnagar, Saman Seraj, Anchal Goel, Palak Mishra
Pyogenic granuloma (PG) is a benign vascular lesion typically caused by trauma or chronic irritation. Although uncommon in pediatric patients, it can have significant implications for dental development. This report discusses the case of a 12-year-old girl presenting with a PG in the lower left back tooth region, obstructing the eruption of a permanent premolar. Surgical removal of the lesion successfully restored the normal eruption process without complications. This case highlights the critical importance of timely diagnosis and intervention to prevent developmental disruptions in pediatric dentistry.
{"title":"Interference in permanent tooth eruption: A case of lobular capillary hemangioma with retained primary molar","authors":"Bareera Iram, Akash Bhatnagar, Saman Seraj, Anchal Goel, Palak Mishra","doi":"10.1016/j.pdj.2025.100347","DOIUrl":"10.1016/j.pdj.2025.100347","url":null,"abstract":"<div><div>Pyogenic granuloma (PG) is a benign vascular lesion typically caused by trauma or chronic irritation. Although uncommon in pediatric patients, it can have significant implications for dental development. This report discusses the case of a 12-year-old girl presenting with a PG in the lower left back tooth region, obstructing the eruption of a permanent premolar. Surgical removal of the lesion successfully restored the normal eruption process without complications. This case highlights the critical importance of timely diagnosis and intervention to prevent developmental disruptions in pediatric dentistry.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 2","pages":"Article 100347"},"PeriodicalIF":0.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
No long-term dental studies have been conducted on tooth eruption in patients with Trisomy 9p syndrome.
Case presentation
We report a case of a child with a duplication restricted to p24.3 of chromosome 9 and a severe delayed eruption of permanent teeth. Timely extraction of the deciduous teeth prevented the need for orthodontic treatment to address the impacted permanent teeth.
Conclusion
Achieving healthy dentition and occlusion can contribute to overall health, significantly enhancing the quality of life. Therefore, treatment strategies to allow the eruption of permanent teeth from an early age are crucial in this syndrome.
{"title":"A case report on long-term management of trisomy 9p syndrome with severe delayed eruption","authors":"Kimiko Ueda , Yuki Akazawa , Hiroshi Nakagawa , Yoshihito Yamakawa , Yukari Suzuki , Tomonori Iwasaki","doi":"10.1016/j.pdj.2025.100344","DOIUrl":"10.1016/j.pdj.2025.100344","url":null,"abstract":"<div><h3>Background</h3><div>No long-term dental studies have been conducted on tooth eruption in patients with Trisomy 9p syndrome.</div></div><div><h3>Case presentation</h3><div>We report a case of a child with a duplication restricted to p24.3 of chromosome 9 and a severe delayed eruption of permanent teeth. Timely extraction of the deciduous teeth prevented the need for orthodontic treatment to address the impacted permanent teeth.</div></div><div><h3>Conclusion</h3><div>Achieving healthy dentition and occlusion can contribute to overall health, significantly enhancing the quality of life. Therefore, treatment strategies to allow the eruption of permanent teeth from an early age are crucial in this syndrome.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 2","pages":"Article 100344"},"PeriodicalIF":0.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Three or more supernumerary teeth in a patient without a systemic disease is rarely encountered.
Case presentation
A Japanese boy aged 9 years 1 month was referred for a malformed tooth in the maxillary central region. Panoramic radiography and cone-beam computed tomography revealed four supernumerary teeth inhibiting eruption of the maxillary bilateral central incisors. Extraction of the supernumerary teeth and use of a fenestration technique led to successful eruption of both incisors.
Conclusion
A supernumerary tooth can strongly affect permanent dentition, thus early detection and appropriate management are important.
{"title":"Successful eruption of maxillary bilateral central incisors following extraction of four supernumerary teeth in maxillary anterior region – Case report","authors":"Masatoshi Otsugu , Makoto Okuda , Fumikazu Tojo , Tamami Kadota , Masakazu Hamada , Rena Okawa , Kazuhiko Nakano","doi":"10.1016/j.pdj.2025.100346","DOIUrl":"10.1016/j.pdj.2025.100346","url":null,"abstract":"<div><h3>Background</h3><div>Three or more supernumerary teeth in a patient without a systemic disease is rarely encountered.</div></div><div><h3>Case presentation</h3><div>A Japanese boy aged 9 years 1 month was referred for a malformed tooth in the maxillary central region. Panoramic radiography and cone-beam computed tomography revealed four supernumerary teeth inhibiting eruption of the maxillary bilateral central incisors. Extraction of the supernumerary teeth and use of a fenestration technique led to successful eruption of both incisors.</div></div><div><h3>Conclusion</h3><div>A supernumerary tooth can strongly affect permanent dentition, thus early detection and appropriate management are important.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 2","pages":"Article 100346"},"PeriodicalIF":0.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In Japan, a universal health insurance coverage system has been established, and everyone has equal access to medical care. Therefore, Japan is often considered to have less disparity in living standards than other countries. However, there are few reports on a correlation between social class and health due to the image of fewer individual disparities.
Aim
This study aimed to investigate the association between childhood dental caries and socioeconomic background.
Methods
Using various government statistics sources, we examined the association between childhood dental caries and socioeconomic factors in Japan including the induced abortion rate and number of recognized criminal offenses as objective variables.
Four factors were selected as explanatory variables: monthly income per household, percentage of expenditure on other living expenses, number of penal-code offenses, and clearance rate of penal-code offenses. The induced abortion rates per 1000 women by age for prefectures or induced abortion rates per 1000 women aged 25–29 years for prefectures (‰) were correlated with the prevalence of dental caries in children as explanatory variables.
Results
This study demonstrated a significant effect (p<0.05) of induced abortion on increased childhood dental caries.
Conclusion
Our findings highlight the importance of dentists sharing medical knowledge about obstetrics and pediatrics with the community and other medical professionals through avenues such as community medicine and school health checkups.
{"title":"Relationship between childhood caries and social background: Regarding the novel emerged correlation between induced abortion and dental caries","authors":"Takafumi Nagao , Naoki Nakao , Masataka Nagao , Hiroko Oka , Ayumu Nakashima , Mitsuhiro Uchida , Ayumu Ito , Ryota Nomura , Kazuhiro Shimamura , Akira Namera , Takahiro Harada , Kazuhiro Murata , Kouki Hatori","doi":"10.1016/j.pdj.2025.100341","DOIUrl":"10.1016/j.pdj.2025.100341","url":null,"abstract":"<div><h3>Background</h3><div>In Japan, a universal health insurance coverage system has been established, and everyone has equal access to medical care. Therefore, Japan is often considered to have less disparity in living standards than other countries. However, there are few reports on a correlation between social class and health due to the image of fewer individual disparities.</div></div><div><h3>Aim</h3><div>This study aimed to investigate the association between childhood dental caries and socioeconomic background.</div></div><div><h3>Methods</h3><div>Using various government statistics sources, we examined the association between childhood dental caries and socioeconomic factors in Japan including the induced abortion rate and number of recognized criminal offenses as objective variables.</div><div>Four factors were selected as explanatory variables: monthly income per household, percentage of expenditure on other living expenses, number of penal-code offenses, and clearance rate of penal-code offenses. The induced abortion rates per 1000 women by age for prefectures or induced abortion rates per 1000 women aged 25–29 years for prefectures (‰) were correlated with the prevalence of dental caries in children as explanatory variables.</div></div><div><h3>Results</h3><div>This study demonstrated a significant effect (p<0.05) of induced abortion on increased childhood dental caries.</div></div><div><h3>Conclusion</h3><div>Our findings highlight the importance of dentists sharing medical knowledge about obstetrics and pediatrics with the community and other medical professionals through avenues such as community medicine and school health checkups.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100341"},"PeriodicalIF":0.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-21DOI: 10.1016/j.pdj.2025.100342
Rogyia Hassan , Lamis Kaddam
Objectives
Sickle cell anemia (SCA) is the most common inherited disorder around the world. Several studies revealed a low level of serum zinc among sickle patients. However, none of them investigated the impact of SCA on salivary zinc levels. This is the first conducted to measure zinc level in saliva and its influence on the periodontal health of children and adolescents with SCA.
Results
The mean ages in the sickle cell anemic group were 10.37 ± 4.13 years old, while the mean ages of subjects in the control group were 9.37 ± 3.6 years (P.Value: 0.169). Salivary zinc level was significantly lower among SCA patients (P.Value < 0.001) than control group. None of the participants were diagnosed with periodontitis. The salivary zinc level was significantly higher in SCA with standard pocket depth and no clinical attachment loss than patients diagnosed with gingivitis (P. value:0.025). Sickle patients have a low level of zinc in saliva, which may contribute to some manifestations of sickle cell disease and may make them more susceptible to periodontal disease in the future. We recommend conducting more research on oral and periodontal health among children affected with SCA to improve their quality of life.
{"title":"Assessment of salivary zinc level and its impact on periodontal health among children and adolescence with sickle cell anemia","authors":"Rogyia Hassan , Lamis Kaddam","doi":"10.1016/j.pdj.2025.100342","DOIUrl":"10.1016/j.pdj.2025.100342","url":null,"abstract":"<div><h3>Objectives</h3><div>Sickle cell anemia (SCA) is the most common inherited disorder around the world. Several studies revealed a low level of serum zinc among sickle patients. However, none of them investigated the impact of SCA on salivary zinc levels. This is the first conducted to measure zinc level in saliva and its influence on the periodontal health of children and adolescents with SCA.</div></div><div><h3>Results</h3><div>The mean ages in the sickle cell anemic group were 10.37 ± 4.13 years old, while the mean ages of subjects in the control group were 9.37 ± 3.6 years (P.Value: 0.169). Salivary zinc level was significantly lower among SCA patients (P.Value < 0.001) than control group. None of the participants were diagnosed with periodontitis. The salivary zinc level was significantly higher in SCA with standard pocket depth and no clinical attachment loss than patients diagnosed with gingivitis (P. value:0.025). Sickle patients have a low level of zinc in saliva, which may contribute to some manifestations of sickle cell disease and may make them more susceptible to periodontal disease in the future. We recommend conducting more research on oral and periodontal health among children affected with SCA to improve their quality of life.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100342"},"PeriodicalIF":0.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-20DOI: 10.1016/j.pdj.2025.100343
Ali Azhar Dawasaz , Dinesh Kumar , Anuj Shukla , Lakshya Raj Khatri , Rafi A. Togoo , Zuliani Mahmood , Ahmad Azlina , Kannan Thirumulu Ponnuraj
Objectives
Salivary proton Nuclear Magnetic Resonance Spectroscopy (1H NMR) has been widely used in metabonomic studies. A research gap still exists in analysing the metabolic profile in obese children suffering from severe dental caries. The aim of this study was to analyse the most identified metabolites in 10–12 years old obese children with severe dental caries and compare them with normal healthy age-matched children.
Materials and methods
Obese children with Body Mass Index Z-score > +2 (n = 20) and normal weight children (control) (n = 20) with severe caries underwent 1.5 mL saliva collection followed by 1H NMR imaging. Spectra were analysed using TopSpin 3.5 and metabolite assignments were made using Chenomx NMR suite and human metabolite database.
Results
A total of 38 common metabolites were identified out of which eight were significantly increased in obese children (p < 0.05). Succinylacetone and glutamine among eight other metabolites significantly increased in the saliva of obese children suffering from severe dental caries. They were also the top contributors in the VIP score plot.
Conclusions
Thirteen (3 amino acids, 4 carboxylic acids, 2 ketoacids, 1 alcohol and 3 miscellaneous metabolites) out of the 38 metabolites identified in normal and obese children with severe dental caries, had high VIP score. Glutamine and succinylacetone showed the highest VIP score with eight metabolites significantly increased in the saliva of obese children.
Clinical relevance
This study could pave way in advancing our understanding of the relationship between caries and obesity and the potential role the metabolites can play in comparison with the normal individuals.
{"title":"Salivary 1H NMR analysis of obese pediatric patients with severe dental caries","authors":"Ali Azhar Dawasaz , Dinesh Kumar , Anuj Shukla , Lakshya Raj Khatri , Rafi A. Togoo , Zuliani Mahmood , Ahmad Azlina , Kannan Thirumulu Ponnuraj","doi":"10.1016/j.pdj.2025.100343","DOIUrl":"10.1016/j.pdj.2025.100343","url":null,"abstract":"<div><h3>Objectives</h3><div>Salivary proton Nuclear Magnetic Resonance Spectroscopy (<sup>1</sup>H NMR) has been widely used in metabonomic studies. A research gap still exists in analysing the metabolic profile in obese children suffering from severe dental caries. The aim of this study was to analyse the most identified metabolites in 10–12 years old obese children with severe dental caries and compare them with normal healthy age-matched children.</div></div><div><h3>Materials and methods</h3><div>Obese children with Body Mass Index Z-score > +2 (<em>n</em> = 20) and normal weight children (control) (<em>n</em> = 20) with severe caries underwent 1.5 mL saliva collection followed by <sup>1</sup>H NMR imaging. Spectra were analysed using TopSpin 3.5 and metabolite assignments were made using Chenomx NMR suite and human metabolite database.</div></div><div><h3>Results</h3><div>A total of 38 common metabolites were identified out of which eight were significantly increased in obese children (p < 0.05). Succinylacetone and glutamine among eight other metabolites significantly increased in the saliva of obese children suffering from severe dental caries. They were also the top contributors in the VIP score plot.</div></div><div><h3>Conclusions</h3><div>Thirteen (3 amino acids, 4 carboxylic acids, 2 ketoacids, 1 alcohol and 3 miscellaneous metabolites) out of the 38 metabolites identified in normal and obese children with severe dental caries, had high VIP score. Glutamine and succinylacetone showed the highest VIP score with eight metabolites significantly increased in the saliva of obese children.</div></div><div><h3>Clinical relevance</h3><div>This study could pave way in advancing our understanding of the relationship between caries and obesity and the potential role the metabolites can play in comparison with the normal individuals.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100343"},"PeriodicalIF":0.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-30DOI: 10.1016/j.pdj.2025.100340
Mario Alberto Alarcón-Sánchez , Julieta Sarai Becerra-Ruiz , Carmen Celina Alonso-Sánchez , Sonia Isela Vázquez-Jiménez , Lilibeth-Stephania Escoto-Vasquez , Seyed Ali Mosaddad , Artak Heboyan
Background
Molar-incisor hypomineralization (MIH) is a qualitative defect in enamel formation with a multifactorial etiology. Studies indicate a high prevalence of MIH across the Americas, yet the prevalence in Mexico remains uncertain.
Aim
This study aimed to review the literature on the prevalence of MIH in the Mexican population and its associated factors.
Methods
Six electronic databases were searched for relevant studies: PubMed, Scopus, Dentistry & Oral Science, Science Direct, Web of Science, and Google Scholar, covering the period from March 10th, 2024. Cross-sectional studies were assessed for risk of bias using the Joanna Briggs Institute (JBI) tool.
Results
Nine studies met the inclusion criteria, encompassing 5039 children aged 6–12 years, with a mean age of 9.02 ± 1.19 years; 50.1% were boys, and 49.9% were girls. The overall prevalence of MIH was 23%, with a higher prevalence in boys (34.1%) than in girls (30.4%). MIH was more common in molars (30.7%) than in incisors (10.8%), with no cases reported in permanent second molars. Five studies (55.5%) noted dental caries in MIH-affected individuals, with 78.7% showing caries and 21.3% caries-free. The JBI analysis found 33.3% of studies with moderate risk and 66.7% with low risk of bias.
Conclusion
The prevalence of MIH in Mexico aligns with rates reported in Brazil and Venezuela. The evidence indicates no significant gender differences in MIH distribution, with molars being more frequently affected than incisors. A substantial proportion of Mexican children with MIH also present with dental caries.
{"title":"Prevalence of molar-incisor hypomineralization in Mexican population: A systematic review and meta-analysis","authors":"Mario Alberto Alarcón-Sánchez , Julieta Sarai Becerra-Ruiz , Carmen Celina Alonso-Sánchez , Sonia Isela Vázquez-Jiménez , Lilibeth-Stephania Escoto-Vasquez , Seyed Ali Mosaddad , Artak Heboyan","doi":"10.1016/j.pdj.2025.100340","DOIUrl":"10.1016/j.pdj.2025.100340","url":null,"abstract":"<div><h3>Background</h3><div>Molar-incisor hypomineralization (MIH) is a qualitative defect in enamel formation with a multifactorial etiology. Studies indicate a high prevalence of MIH across the Americas, yet the prevalence in Mexico remains uncertain.</div></div><div><h3>Aim</h3><div>This study aimed to review the literature on the prevalence of MIH in the Mexican population and its associated factors.</div></div><div><h3>Methods</h3><div>Six electronic databases were searched for relevant studies: PubMed, Scopus, Dentistry & Oral Science, Science Direct, Web of Science, and Google Scholar, covering the period from March 10th, 2024. Cross-sectional studies were assessed for risk of bias using the Joanna Briggs Institute (JBI) tool.</div></div><div><h3>Results</h3><div>Nine studies met the inclusion criteria, encompassing 5039 children aged 6–12 years, with a mean age of 9.02 ± 1.19 years; 50.1% were boys, and 49.9% were girls. The overall prevalence of MIH was 23%, with a higher prevalence in boys (34.1%) than in girls (30.4%). MIH was more common in molars (30.7%) than in incisors (10.8%), with no cases reported in permanent second molars. Five studies (55.5%) noted dental caries in MIH-affected individuals, with 78.7% showing caries and 21.3% caries-free. The JBI analysis found 33.3% of studies with moderate risk and 66.7% with low risk of bias.</div></div><div><h3>Conclusion</h3><div>The prevalence of MIH in Mexico aligns with rates reported in Brazil and Venezuela. The evidence indicates no significant gender differences in MIH distribution, with molars being more frequently affected than incisors. A substantial proportion of Mexican children with MIH also present with dental caries.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100340"},"PeriodicalIF":0.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Down syndrome (DS) is often associated with delayed teeth eruption, gross motor skill acquisition, and feeding difficulties. In typically developing (TD) children, changes in weaning food texture with deciduous teeth eruption and motor skill acquisition, which improves feeding skills. However, in DS, these processes are delayed, and age alone is not a reliable predictor for such changes. Therefore, we investigated the association between these parameters in children with DS.
Methods
We administered questionnaires to parents of 56 children with DS aged 0–3 years. The survey items included timing of deciduous tooth eruption, physical development, acquired gross motor skills, and texture of weaning foods being consumed. The included children were allocated to two groups according to the confirmed eruption of mandibular deciduous central incisor by or after 12 months.
Results
The groups significantly differed in height, Kaup index, and acquisition age of pulling to stand, as determined by Mann–Whitney U test. Furthermore, multiple regression analysis revealed a significant association between the age of mandibular central incisor eruption and height along with that of acquisition age of pulling to stand. However, no significant difference was observed in the texture of weaning foods.
Conclusion
The observed associations between the eruption of mandibular central incisor, height, and acquisition age of pulling to stand suggest an association between teeth eruption, physical development, and motor development. Despite no differences in weaning food texture, most patients developed dysphagia habilitation, indicating the need to adjust food texture based on delays in physical and motor development.
{"title":"Deciduous teeth eruption, gross motor skills, and feeding in children with down syndrome: A cross-sectional study","authors":"Nami Hisamoto , Masahiro Watanabe , Sachiyo Hayashi , Akiko Chigira , Satoko Otsuka , Masae Ono , Akemi Utsumi , Akiko Ishizaki , Luna Osakabe , Mami Ota , Satoko Yamaguchi , Kentaro Ishikawa , Kazutaka Noda , Shouji Hironaka","doi":"10.1016/j.pdj.2024.100339","DOIUrl":"10.1016/j.pdj.2024.100339","url":null,"abstract":"<div><h3>Introduction</h3><div>Down syndrome (DS) is often associated with delayed teeth eruption, gross motor skill acquisition, and feeding difficulties. In typically developing (TD) children, changes in weaning food texture with deciduous teeth eruption and motor skill acquisition, which improves feeding skills. However, in DS, these processes are delayed, and age alone is not a reliable predictor for such changes. Therefore, we investigated the association between these parameters in children with DS.</div></div><div><h3>Methods</h3><div>We administered questionnaires to parents of 56 children with DS aged 0–3 years. The survey items included timing of deciduous tooth eruption, physical development, acquired gross motor skills, and texture of weaning foods being consumed. The included children were allocated to two groups according to the confirmed eruption of mandibular deciduous central incisor by or after 12 months.</div></div><div><h3>Results</h3><div>The groups significantly differed in height, Kaup index, and acquisition age of pulling to stand, as determined by Mann–Whitney <em>U</em> test. Furthermore, multiple regression analysis revealed a significant association between the age of mandibular central incisor eruption and height along with that of acquisition age of pulling to stand. However, no significant difference was observed in the texture of weaning foods.</div></div><div><h3>Conclusion</h3><div>The observed associations between the eruption of mandibular central incisor, height, and acquisition age of pulling to stand suggest an association between teeth eruption, physical development, and motor development. Despite no differences in weaning food texture, most patients developed dysphagia habilitation, indicating the need to adjust food texture based on delays in physical and motor development.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100339"},"PeriodicalIF":0.6,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-11DOI: 10.1016/j.pdj.2024.100338
Anum Khan, Ghaida Al-Jaddir, Jo Maynard, Hani Dajani, Kathleen Villanueva, Kate Barnard, Jacqui Gillet
Burkitt’s lymphoma (BL) is a non-Hodgkin Lymphoma (NHL) type fast growing neoplasm of the B-cells and is one of the most common subtypes of paediatric lymphomas. A case of 5 years old female presenting with pain and abnormal teeth mobility in the mandible and swelling of right eye. The initial presentation coincided with multiple organ involvement and urgent referral to Oncology was made. Chemotherapy was initiated and patient was in remission within two months, remains in remission 22 months later. This case reports stresses on dentists and GP recognising signs of abnormal presentations and referring to relevant specialities to ensure early detection and management.
{"title":"Oral manifestations of Burkitts Lymphoma - Literature review and case report of Burkitt's lymphoma in a 5 years old female","authors":"Anum Khan, Ghaida Al-Jaddir, Jo Maynard, Hani Dajani, Kathleen Villanueva, Kate Barnard, Jacqui Gillet","doi":"10.1016/j.pdj.2024.100338","DOIUrl":"10.1016/j.pdj.2024.100338","url":null,"abstract":"<div><div>Burkitt’s lymphoma (BL) is a non-Hodgkin Lymphoma (NHL) type fast growing neoplasm of the B-cells and is one of the most common subtypes of paediatric lymphomas. A case of 5 years old female presenting with pain and abnormal teeth mobility in the mandible and swelling of right eye. The initial presentation coincided with multiple organ involvement and urgent referral to Oncology was made. Chemotherapy was initiated and patient was in remission within two months, remains in remission 22 months later. This case reports stresses on dentists and GP recognising signs of abnormal presentations and referring to relevant specialities to ensure early detection and management.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100338"},"PeriodicalIF":0.6,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-08DOI: 10.1016/j.pdj.2024.100337
Hidenori Kokubo , Yuta Chiba , Triana Marchelina , Kifu Miyata , Hidenori Oikawa , Rion Sho , Kan Saito , Aya Yamada , Satoshi Fukumoto
Objectives
Dental anomalies are often associated with inherited diseases and are frequently seen in the field of pediatric dentistry. Dentin disorders are caused by genetic mutations of genes expressed in dental mesenchyme and these genetic mutations also cause skeletal dysplasia. However, only little genes are identified as the responsible gene of dentin disorders and therefore the genetic mechanism is poorly understood. Here, we identified the dental mesenchymal cell-specific genes using single-cell RNA-sequence (scRNA-seq) to clarify the pathogenesis of dentin disorders. Furthermore, we examined the association of inherited disease with dentin or skeletal abnormality using human disease database.
Materials and methods
scRNA-seq were performed using post-natal day (P) seven mice incisor. Total 6260 cells of scRNA-seq dataset was obtained. Top 20 differentially expressed genes (DEGs) in odontoblast cluster and dental pulp cluster were identified. Inherited diseases of DEGs and their Clinical Synopsis were examined using Online Mendelian Inheritance in Man (OMIM).
Results
The prevalence of inherited disease was 17/40 genes (42.5 %) and dental anomalies-associated inherited diseases were 12/35 diseases (34.3 %); 2.8 % in enamel abnormality, 14.3 % in dentin abnormality, and 17.1 % in other abnormality. The prevalence of dentin abnormality was 33.3 % in odontoblast and 7.7 % in dental pulp-associated diseases. The prevalence of skeletal abnormality in identified inherited diseases was 85.7 %.
Conclusion
The DEGs in dental mesenchymal cells were highly associated with dentin abnormality and skeletal abnormality. Identification of dental mesenchymal cell specific genes using scRNA-seq may uncover the novel genetic mechanism of dentin disorders.
{"title":"Integration of single cell analysis of dental mesenchyme and human disease database identifies the responsible gene of dentin disorders","authors":"Hidenori Kokubo , Yuta Chiba , Triana Marchelina , Kifu Miyata , Hidenori Oikawa , Rion Sho , Kan Saito , Aya Yamada , Satoshi Fukumoto","doi":"10.1016/j.pdj.2024.100337","DOIUrl":"10.1016/j.pdj.2024.100337","url":null,"abstract":"<div><h3>Objectives</h3><div>Dental anomalies are often associated with inherited diseases and are frequently seen in the field of pediatric dentistry. Dentin disorders are caused by genetic mutations of genes expressed in dental mesenchyme and these genetic mutations also cause skeletal dysplasia. However, only little genes are identified as the responsible gene of dentin disorders and therefore the genetic mechanism is poorly understood. Here, we identified the dental mesenchymal cell-specific genes using single-cell RNA-sequence (scRNA-seq) to clarify the pathogenesis of dentin disorders. Furthermore, we examined the association of inherited disease with dentin or skeletal abnormality using human disease database.</div></div><div><h3>Materials and methods</h3><div>scRNA-seq were performed using post-natal day (P) seven mice incisor. Total 6260 cells of scRNA-seq dataset was obtained. Top 20 differentially expressed genes (DEGs) in odontoblast cluster and dental pulp cluster were identified. Inherited diseases of DEGs and their Clinical Synopsis were examined using Online Mendelian Inheritance in Man (OMIM).</div></div><div><h3>Results</h3><div>The prevalence of inherited disease was 17/40 genes (42.5 %) and dental anomalies-associated inherited diseases were 12/35 diseases (34.3 %); 2.8 % in enamel abnormality, 14.3 % in dentin abnormality, and 17.1 % in other abnormality. The prevalence of dentin abnormality was 33.3 % in odontoblast and 7.7 % in dental pulp-associated diseases. The prevalence of skeletal abnormality in identified inherited diseases was 85.7 %.</div></div><div><h3>Conclusion</h3><div>The DEGs in dental mesenchymal cells were highly associated with dentin abnormality and skeletal abnormality. Identification of dental mesenchymal cell specific genes using scRNA-seq may uncover the novel genetic mechanism of dentin disorders.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100337"},"PeriodicalIF":0.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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