Dietary flavonoids: Promising compounds for targeting α-synucleinopathy in Parkinson’s disease

IF 2.4 Q3 NUTRITION & DIETETICS PharmaNutrition Pub Date : 2023-06-01 DOI:10.1016/j.phanu.2023.100334
Marzieh Harati , Zahra Tayarani-Najaran , Behjat Javadi
{"title":"Dietary flavonoids: Promising compounds for targeting α-synucleinopathy in Parkinson’s disease","authors":"Marzieh Harati ,&nbsp;Zahra Tayarani-Najaran ,&nbsp;Behjat Javadi","doi":"10.1016/j.phanu.2023.100334","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p><span>Alpha-synuclein (α-syn) aggregates contribute to neuronal damage and many neurodegenerative disorders (NDs) which are known as α-synucleinopathies. </span>Flavonoids<span><span> are polyphenolic compounds extensively found in various plant-based food such as fruits and vegetables. They have potential benefits in </span>human health, especially in α-synucleinopathy-associated NDs.</span></p></div><div><h3>Objective</h3><p>This review summarizes the latest scientific evidence on the impact of flavonoids on α-synucleinopathy, particularly in Parkinson’s disease</p></div><div><h3>Methods</h3><p>A comprehensive literature search of Web of Science, PubMed, Scopus and Google Scholar was performed to obtain relevant research studies reporting the anti- synucleinopathies effects of dietary flavonoids</p></div><div><h3>Results</h3><p><span><span><span><span>Baicalein, </span>luteolin, </span>quercetin, myricitrin, epigallocatechin-3-gallate and </span>genistein are among the most effective flavonoids against synucleinopathies. The main mechanisms of action contributing to these effects are reducing α-syn production; preventing α-syn aggregation and reducing preformed aggregates; promoting degradation of intracellular α-syn aggregates through autophagy; modulating the activity/expression of antioxidant enzymes; and protecting </span>dopaminergic<span> neurons from oxidative damage and apoptosis</span></p></div><div><h3>Conclusions</h3><p><span>The results of this review highlighted the beneficial effects of flavonoids in the prevention and management of synucleinopathies. However, there is no clinical data that support these effects in humans, which emphasizes the necessity for designing clinical trials to investigate the efficacy, safe dosage, possible side effects and </span>pharmacokinetics characteristics of flavonoids in humans.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"24 ","pages":"Article 100334"},"PeriodicalIF":2.4000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PharmaNutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213434423000063","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Alpha-synuclein (α-syn) aggregates contribute to neuronal damage and many neurodegenerative disorders (NDs) which are known as α-synucleinopathies. Flavonoids are polyphenolic compounds extensively found in various plant-based food such as fruits and vegetables. They have potential benefits in human health, especially in α-synucleinopathy-associated NDs.

Objective

This review summarizes the latest scientific evidence on the impact of flavonoids on α-synucleinopathy, particularly in Parkinson’s disease

Methods

A comprehensive literature search of Web of Science, PubMed, Scopus and Google Scholar was performed to obtain relevant research studies reporting the anti- synucleinopathies effects of dietary flavonoids

Results

Baicalein, luteolin, quercetin, myricitrin, epigallocatechin-3-gallate and genistein are among the most effective flavonoids against synucleinopathies. The main mechanisms of action contributing to these effects are reducing α-syn production; preventing α-syn aggregation and reducing preformed aggregates; promoting degradation of intracellular α-syn aggregates through autophagy; modulating the activity/expression of antioxidant enzymes; and protecting dopaminergic neurons from oxidative damage and apoptosis

Conclusions

The results of this review highlighted the beneficial effects of flavonoids in the prevention and management of synucleinopathies. However, there is no clinical data that support these effects in humans, which emphasizes the necessity for designing clinical trials to investigate the efficacy, safe dosage, possible side effects and pharmacokinetics characteristics of flavonoids in humans.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
膳食黄酮类化合物:靶向帕金森病α-突触核蛋白病的有前景的化合物
背景α-突触核蛋白(α-syn)聚集体导致神经元损伤和许多神经退行性疾病(ND),这些疾病被称为α-突触蛋白病。黄酮类化合物是多酚类化合物,广泛存在于各种植物性食品中,如水果和蔬菜。它们对人类健康有潜在的益处,特别是在α-突触核蛋白病相关的NDs中。目的本文综述了黄酮类化合物对α-突触蛋白病的影响,特别是对帕金森病的影响的最新科学证据,Scopus和Google Scholar进行了相关研究,报道了膳食黄酮类化合物的抗突触核蛋白病作用。导致这些效应的主要作用机制是减少α-syn的产生;防止α-syn聚集并减少预形成的聚集体;通过自噬促进细胞内α-syn聚集体的降解;调节抗氧化酶的活性/表达;以及保护多巴胺能神经元免受氧化损伤和凋亡。结论本综述的结果强调了黄酮类化合物在预防和治疗突触核蛋白疾病中的有益作用。然而,没有临床数据支持这些对人体的影响,这强调了设计临床试验以研究黄酮类化合物在人体中的疗效、安全剂量、可能的副作用和药代动力学特征的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
PharmaNutrition
PharmaNutrition Agricultural and Biological Sciences-Food Science
CiteScore
5.70
自引率
3.10%
发文量
33
审稿时长
12 days
期刊最新文献
Efficacy and safety of crocin supplementation in patients with central serous chorioretinopathy, a pilot randomized double blinded clinical trial Dietitians’ knowledge and practice regarding inflammaging and related interventions: A pilot survey Exploring the molecular mechanisms and therapeutic benefits of L-theanine in counteracting inflammation Enhanced absorption of omega-3 fatty acids from a novel krill oil-derived phospholipid formulation compared to fish oil ethyl esters: A randomized, two-way crossover pharmacokinetic study Milk fat globule membrane: Production, digestion, and health benefits evaluated through in vitro models
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1