{"title":"The Effect of Consanguinity on Reproductive Fitness and Selection Intensity in the Muslim Population of Western Uttar Pradesh, India","authors":"M. Afzal","doi":"10.31901/24566608.2021/74.1-3.3321","DOIUrl":null,"url":null,"abstract":"ABSTRACT The study sought to ascertain the adverse effects of consanguinity among Muslim parents of Aligarh city located in western Uttar Pradesh in India. More than 478 families were visited and data were collected from only 100 of them being inbred to varying degrees of consanguinity. It was found that increasing degree of consanguinity decreases fertility (R2 = 0.2671, r = -0.1568), but increases mortality (R2 = 0.3161, r = 0.5622). Selection intensity (R2 = 0.1734, r = 0.4164) and secondary sex ratio (R2 = 0.3757, r = 0.6129) also go up as the degree of consanguinity increases. However, the genomic basis of Runs of Homozygosity (ROH) is a more accurate method of calculating homozygosity. Next Generation Sequencing may help better understand ROH and their utility as a tool for inbreeding detection. To avoid the inbreeding load, there is a need to raise public awareness of reproductive health and the potential negative effects of consanguinity.","PeriodicalId":35217,"journal":{"name":"Journal of Human Ecology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Human Ecology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31901/24566608.2021/74.1-3.3321","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Environmental Science","Score":null,"Total":0}
引用次数: 1
Abstract
ABSTRACT The study sought to ascertain the adverse effects of consanguinity among Muslim parents of Aligarh city located in western Uttar Pradesh in India. More than 478 families were visited and data were collected from only 100 of them being inbred to varying degrees of consanguinity. It was found that increasing degree of consanguinity decreases fertility (R2 = 0.2671, r = -0.1568), but increases mortality (R2 = 0.3161, r = 0.5622). Selection intensity (R2 = 0.1734, r = 0.4164) and secondary sex ratio (R2 = 0.3757, r = 0.6129) also go up as the degree of consanguinity increases. However, the genomic basis of Runs of Homozygosity (ROH) is a more accurate method of calculating homozygosity. Next Generation Sequencing may help better understand ROH and their utility as a tool for inbreeding detection. To avoid the inbreeding load, there is a need to raise public awareness of reproductive health and the potential negative effects of consanguinity.
本研究旨在确定位于印度北方邦西部的阿里加尔市穆斯林父母的血缘关系的不利影响。研究人员访问了478个家庭，仅收集了其中100个不同程度近亲繁殖的家庭的数据。结果表明，亲缘关系越高，生育力越低(R2 = 0.2671, r = -0.1568)，死亡率越高(R2 = 0.3161, r = 0.5622)。选择强度(R2 = 0.1734, r = 0.4164)和第二性比(R2 = 0.3757, r = 0.6129)也随亲缘关系的增加而增加。然而，纯合子的基因组基础(run of Homozygosity, ROH)是一种更准确的纯合子计算方法。下一代测序可能有助于更好地了解ROH及其作为近交检测工具的用途。为了避免近亲繁殖负担，有必要提高公众对生殖健康和近亲关系潜在负面影响的认识。
期刊介绍：
The Journal of Human Ecology publishes empirical and theoretical research, short notes and brief communications probing the interface between human beings and their environment. The journal also has a section dedicated to reviews. The contributions combine ideas and methods from several disciplines, including, but not confined to, physical anthropology, health awareness, sustainability and development, sociology, forestry, psychology and agriculture. The journal also accepts research that focuses on the well-being of those with physical or mental challenges, the importance of food safety, measures taken to improve public health, and the sociological aspect of human ecology.
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