Castleman's disease as an unusual cause of back pain in childhood

Abstract

Rationale: Castleman's disease (CD) is an uncommon lymphoproliferative disorder that is distinguished by the presence of exotic heavy growth of lymphoid tissue. It is divided into two types: unicentric (localised) and multicentric (systemic) subtypes. Excision is the ideal therapeutic option for localised disease. Patient concern: Patient had a chronic back pain which affecting his daily activity. Diagnosis: The diagnosis of CD was incidentally detected on a magnetic resonance imaging of the lumbar spine performed for back pain and revealed retroperitoneal paracaval lymphadenopathy, which was then excised, and the histopathology confirmed CD. Outcome: Surgical excision resulted in complete resolution of his back pain. Lessons: CD has unspecific clinical presentation and back pain is unusual presentation in our case. In addition, our patient had Noonan's syndrome suggesting a possible association with CD.