Synthesis and characterization of barium titanate/polyacrylonitrile nanocomposite for electrochemical sensing of doxorubicin

Abstract

A microwave (MW) assisted process was evolved to synthesize a series of polymer nanocomposites (PNCs) through 2,2-azobisisobutyronitrile (AIBN) initiated free radical in situ polymerization of acrylonitrile (AN) in presence of nanobariumtitanate (NBT). The reaction conditions were optimized and microwave power ranging 25 to 100 W over 10 min was found to be most suited for the synthesis of PNCs. Synthesis of PNCs has been ascertained through UV–vis, FTIR spectroscopy and microstructure were investigated through XRD and AFM. TG-DTA-DTG proclaims that PNCs acquire lower moisture content and higher heat resistance as compared to polyacrylonitrile (PAN). The synthesized PNCs have been applied as sensing material to develop electrochemical probe for detection of doxorubicin (DOX). The presence of DOX (0.01%, w/v) in phosphate buffer at pH 7.4 has shown a remarkable increase in the peak current at PNCs modified glassy carbon electrode (GCE). Cyclic voltammetric (CV) studies proof good acceptance of nanocomposites as sensing material for anti cancerous drug DOX.