C. C. Kurashova, A. Ishmukhametov, M. Egorova, M. Balovneva, T. Dzagurova, E. Tkachenko
{"title":"Comparative Characteristics of Inactivation Agents for HFRS Vaccine Development","authors":"C. C. Kurashova, A. Ishmukhametov, M. Egorova, M. Balovneva, T. Dzagurova, E. Tkachenko","doi":"10.31631/2073-3046-2018-17-4-26-29","DOIUrl":null,"url":null,"abstract":"The results of various methods of Puumala virus inactivation, including ultraviolet rays (UV), β -propiolactone (BPL) and formalin are presented. Immunogenicity of vaccine preparations obtained using these virus inactivation methods did not differ significantly in the experiments on BALB/c mice. Essential advantage of UV and BPL in relation to formaldehyde is the short time of virus inactivation.","PeriodicalId":36064,"journal":{"name":"Epidemiologiya i Vaktsinoprofilaktika","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epidemiologiya i Vaktsinoprofilaktika","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31631/2073-3046-2018-17-4-26-29","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 2
Abstract
The results of various methods of Puumala virus inactivation, including ultraviolet rays (UV), β -propiolactone (BPL) and formalin are presented. Immunogenicity of vaccine preparations obtained using these virus inactivation methods did not differ significantly in the experiments on BALB/c mice. Essential advantage of UV and BPL in relation to formaldehyde is the short time of virus inactivation.
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