The role of PR 10 proteins and molecular components of moulds and yeast in atopic dermatitis patients

IF 1.7 3区农林科学 Q3 CHEMISTRY, APPLIED Food and Agricultural Immunology Pub Date : 2022-10-20 DOI:10.1080/09540105.2022.2130183

J. Čelakovská, R. Vankova, H. Skalská, J. Krejsek, C. Andrys

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Abstract

ABSTRACT This study aims to analyse the results of specific IgE to molecular components of PR 10 proteins, mould and yeast in atopic dermatitis (AD) patients, to find significant sets of molecular components in pairs and triplets in the relation to the severity of atopic dermatitis and the occurrence of asthma bronchiale and allergic rhinitis. The examination of the sensitization to molecular components with ALEX2 Allergy Explorer testing was performed. The level of specific IgE was recorded with Jittered box plots, the Kruskal–Wallis test was used to compare the level of specific IgE in different forms of AD. The relation between the results of specific IgE was evaluated with Coefficient of correlation (Kendall tau-b). The comparison of significant rules was performed with Fisher–Freeman–Halton exact test and with tests on proportions. Altogether 100 atopic dermatitis patients were examined. Molecular components Fra a 1 + 3, Mal d 1, Api g 1, Mala s 11 and Asp f 6 are recorded as a single molecular component with relation to the severe form of AD; these components are associated in pairs and triplets with molecular components Cor a 1.0401, Cor a 1.0103, Fag s 1, Alt a 1 and with the occurrence of allergic rhinitis. Results are presented in static and interactive tables and plots.

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PR 10蛋白及霉菌和酵母分子组分在特应性皮炎患者中的作用

摘要本研究旨在分析特应性皮炎（AD）患者PR 10蛋白、霉菌和酵母分子组分的特异性IgE结果，以发现与特应性皮肤炎的严重程度、哮喘支气管哮喘和过敏性鼻炎的发生有关的成对和三重组分的重要分子组分。用ALEX2 Allergy Explorer测试对分子成分的致敏性进行检查。特异性IgE水平用吉布盒图记录，Kruskal–Wallis检验用于比较不同形式AD中的特异性IgE水平。用相关系数（Kendall tau-b）评估特异性IgE.结果之间的关系。显著规则的比较采用Fisher–Freeman–Halton精确检验和比例检验。共检查了100名特应性皮炎患者。分子组分Fra a 1 + 3、Mal d1、Api g1、Mala s11和Asp f6被记录为与严重形式的AD有关的单一分子组分；这些组分与分子组分Cor a 1.0401、Cor a 1.0103、Fag s 1、Alt a 1成对和三联体相关，并与过敏性鼻炎的发生相关。结果显示在静态和交互式表格和图表中。

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来源期刊

Food and Agricultural Immunology 农林科学-毒理学

CiteScore

5.30

自引率

6.70%

发文量

审稿时长

2 months

期刊介绍： Food and Agricultural Immunology is an international open access journal publishing original immunological research with applications in food, agricultural, environmental and veterinary science. Submissions describing the use of immunological techniques and methods are particularly welcomed. The journal aims to expand our understanding of the interactions at the interface of food and immune systems including studies on: -Development of diagnostic systems – all types of ligand-based assays, e.g. antibody, aptamer -Application of ligand-based assays for the detection or identification of molecules of interest in food science, agricultural research, veterinary investigations and clinical systems relating to food allergy or sensitivity to agricultural chemicals -Effects of food on the immune system -Studies on allergy and allergic reactions -Investigations into food allergies -Development of allergen-free food systems -Development of novel assay formats -Applications of assay systems to the monitoring of food items in relation to safety and labelling -Food quality issues, e.g. speciation, adulteration and contamination -Comparisons between different analytical techniques The journal publishes research and review articles and is essential reading for food scientists, immunologists and all those concerned with the interaction between food and immune systems.