Prefrontal Regulation of Threat-Elicited Behaviors: A Pathway to Translation.

IF 23.6 1区心理学 Q1 PSYCHOLOGY Annual review of psychology Pub Date : 2020-01-06 DOI:10.1146/annurev-psych-010419-050905

A. Roberts

{"title":"Prefrontal Regulation of Threat-Elicited Behaviors: A Pathway to Translation.","authors":"A. Roberts","doi":"10.1146/annurev-psych-010419-050905","DOIUrl":null,"url":null,"abstract":"Regions of the prefrontal and cingulate cortices play important roles in the regulation of behaviors elicited by threat. Dissecting out their differential involvement will greatly increase our understanding of the varied etiology of symptoms of anxiety. I review evidence for altered activity within the major divisions of the prefrontal cortex, including orbitofrontal, ventrolateral, dorsolateral, and ventromedial sectors, along with the anterior cingulate cortex in patients with clinical anxiety. This review is integrated with a discussion of current knowledge about the causal role of these different prefrontal and cingulate regions in threat-elicited behaviors from experimental studies in rodents and monkeys. I highlight commonalities and inconsistencies between species and discuss the current state of our translational success in relating findings across species. Finally, I identify key issues that, if addressed, may improve that success in the future. Expected final online publication date for the Annual Review of Psychology, Volume 71 is January 4, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8010,"journal":{"name":"Annual review of psychology","volume":" ","pages":""},"PeriodicalIF":23.6000,"publicationDate":"2020-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-psych-010419-050905","citationCount":"34","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of psychology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1146/annurev-psych-010419-050905","RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHOLOGY","Score":null,"Total":0}

引用次数: 34

Abstract

Regions of the prefrontal and cingulate cortices play important roles in the regulation of behaviors elicited by threat. Dissecting out their differential involvement will greatly increase our understanding of the varied etiology of symptoms of anxiety. I review evidence for altered activity within the major divisions of the prefrontal cortex, including orbitofrontal, ventrolateral, dorsolateral, and ventromedial sectors, along with the anterior cingulate cortex in patients with clinical anxiety. This review is integrated with a discussion of current knowledge about the causal role of these different prefrontal and cingulate regions in threat-elicited behaviors from experimental studies in rodents and monkeys. I highlight commonalities and inconsistencies between species and discuss the current state of our translational success in relating findings across species. Finally, I identify key issues that, if addressed, may improve that success in the future. Expected final online publication date for the Annual Review of Psychology, Volume 71 is January 4, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

威胁诱发行为的前置调节：翻译之路。

前额叶和扣带皮层区域在威胁引发的行为调节中起着重要作用。解剖他们的不同参与将大大增加我们对焦虑症状的各种病因学的理解。我回顾了临床焦虑症患者前额叶皮层主要分区活动改变的证据，包括眶额、腹外侧、背外侧和腹内内侧，以及前扣带皮层。这篇综述结合了目前关于这些不同的前额叶和扣带区域在啮齿动物和猴子的实验研究中威胁诱发行为的因果作用的讨论。我强调了物种之间的共性和不一致性，并讨论了我们在跨物种相关发现的翻译成功的现状。最后，我指出了一些关键问题，如果这些问题得到解决，可能会在未来取得更大的成功。《心理学年度评论》第71卷的最终在线出版日期预计为2020年1月4日。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Annual review of psychology 医学-心理学

CiteScore

47.30

自引率

0.80%

发文量

期刊介绍： The Annual Review of Psychology, a publication that has been available since 1950, provides comprehensive coverage of the latest advancements in psychological research. It encompasses a wide range of topics, including the biological underpinnings of human behavior, the intricacies of our senses and perception, the functioning of the mind, animal behavior and learning, human development, psychopathology, clinical and counseling psychology, social psychology, personality, environmental psychology, community psychology, and much more. In a recent development, the current volume of this esteemed journal has transitioned from a subscription-based model to an open access format as part of the Annual Reviews' Subscribe to Open initiative. As a result, all articles published in this volume are now freely accessible to the public under a Creative Commons Attribution (CC BY) license.